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Differential Nano-bio Interactions and Toxicity Effects of Pristine Versus Functionalized Graphene

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Nanoscale

Source : Nanoscale, Volume 3, Number 6, p.2461-2464 (2011)

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Keywords : animal, Animals, article, Cell Survival, Cercopithecus, Cercopithecus aethiops, chemical phenomena, chemistry, Confocal, confocal microscopy, drug effect, flow cytometry, Graphite, Hydrophobic and Hydrophilic Interactions, Materials Testing, microscopy, nanomaterial, Nanostructures, oxidative stress, toxicity testing, Toxicity Tests, Vero cell, Vero cells

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2011

Abstract : We report the effect of carboxyl functionalization of graphene in pacifying its strong hydrophobic interaction with cells and associated toxic effects. Pristine graphene was found to accumulate on the cell membrane causing high oxidative stress leading to apoptosis, whereas carboxyl functionalized hydrophilic graphene was internalized by the cells without causing any toxicity.

Cite this Research Publication : Abhilash Sasidharan, Panchakarla, L. S., Chandran, P., Dr. Deepthy Menon, Nair, S., Rao, C. N., and Koyakutty, M., “Differential Nano-bio Interactions and Toxicity Effects of Pristine Versus Functionalized Graphene”, Nanoscale, vol. 3, pp. 2461-2464, 2011.

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