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Experimental therapeutic intervention with alpha tocopherol in ethanol induced testicular injuries in rats

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Indian Journal of Clinical Biochemistry

Source : Indian Journal of Clinical Biochemistry, Volume 22, Number 1, p.138-142 (2007)

Url : http://www.scopus.com/inward/record.url?eid=2-s2.0-33947129097&partnerID=40&md5=f3122d863e9d986600212e8b147526a4

Keywords : 3(or 17)beta hydroxysteroid dehydrogenase, alcohol, alpha tocopherol, anesthetic agent, animal experiment, animal model, animal tissue, Animalia, antioxidant, article, controlled study, defense mechanism, dose response, drug effect, enzyme activity, ether, experimental study, intervention study, lipid peroxidation, male, nonhuman, rat, Rattus, steroidogenic factor 1, testis injury, testis weight, testosterone 17beta dehydrogenase, weight change

Campus : Kochi

School : School of Medicine

Year : 2007

Abstract : Infertility is well-established harmful effect in chronic alcoholism and so far, there is no effective treatment for this condition. The study was conducted to determine the effects of alpha tocopherol on ethanol induced testicular injuries in male albino rats of Wistar strain. Five groups (n=6) of animals were used. Group I served as control. Group II received daily 1.6g ethanol/kg body weight/day for 4 weeks orally. Group III received 1.6g ethanol + 80mg alpha tocopherol/kg body weight/day for four weeks orally. Group IV received 1.6g ethanol /kg body weight for/day 4 weeks and followed by 80mg alpha tocopherol/kg body weight/day for four weeks orally. Group V received 1.6g ethanol/kg body weight/day orally for 4 weeks, followed by 4 weeks abstinence. Twentyfour hours after the last treatment the rats were sacrificed using anesthetic ether. Testes were removed and used for the estimation of extent of lipid peroxidation and tissue levels of antioxidants and steroidogenic enzymes. Alpha tocopherol treatment increased the activities of testicular Δ5, 3β-HSD and 17β-HSD. Moreover, the treatment was also associated with significant decrease in testicular oxidative stress. Ethanol-induced oxidative stress and decreased steroidogenesis can be reversed by treatment with alpha tocopherol.

Cite this Research Publication : Sb Dutta, Maneesh, M., Chakrabarti, A., and Dr. Damodaran Vasudevan, “Experimental therapeutic intervention with alpha tocopherol in ethanol induced testicular injuries in rats”, Indian Journal of Clinical Biochemistry, vol. 22, pp. 138-142, 2007.

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