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Fabrication and Characterization of Chitosan/gelatin/nSiO2 Composite Scaffold for Bone Tissue Engineering

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : International Journal of Biological Macromolecules

Source : International Journal of Biological Macromolecules, Volume 59, p.255-263 (2013)

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Keywords : adsorption, adsorption kinetics, alkaline phosphatase, article, Biocompatible Materials, biodegradability, Biological Markers, biomineralization, bone density, bone swelling, bone tissue, cell adhesion, Cell Line, cell proliferation, chitosan, composite material, controlled study, degradation kinetics, Electron, enzyme activity, Fourier Transform Infrared, freeze drying, gelatin, human, human cell, Humans, in vitro study, infrared spectroscopy, Materials Testing, microscopy, molecular scaffold, nanoanalysis, Nanocomposites, nanofabrication, Osteocytes, porosity, Scanning, scanning electron microscopy, silicon dioxide, Spectroscopy, tissue engineering, Tissue Scaffolds, Tumor

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2013

Abstract : A 3D nanocomposite scaffold of chitosan, gelatin and nano-silica was fabricated by lyophilization to test the hypothesis that incorporation of nano-SiO2 could produce a better candidate for bone tissue engineering compared to pure chitosan and chitosan/gelatin scaffolds. The prepared scaffold was characterized using SEM and FTIR. Porosity, density, swelling, degradation, mechanical integrity, biomineralization and protein adsorption studies, favored it in comparison to the conventional chitosan and chitosan/gelatin scaffolds. In vitro cyto-compatablity, cell attachment-proliferation, ALP activity studies performed using MG-63 cells, advocate its remarkable performance. These cumulative results indicate the prepared nanocomposite scaffold as a prospective candidate for bone tissue engineering. © 2013 Elsevier B.V.

Cite this Research Publication : K. C. Kavya, Dr. Jayakumar Rangasamy, Nair, S., and Chennazhi, K. P., “Fabrication and Characterization of Chitosan/gelatin/nSiO2 Composite Scaffold for Bone Tissue Engineering”, International Journal of Biological Macromolecules, vol. 59, pp. 255-263, 2013.

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