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Fluconazole Loaded Chitin Nanogels as a Topical Ocular Drug Delivery Agent for Corneal Fungal Infections

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Journal of Biomedical Nanotechnology

Source : Journal of Biomedical Nanotechnology, vol. 9, pp. 1521-1531, 2013

Url : http://www.scopus.com/inward/record.url?eid=2-s2.0-84883405060&partnerID=40&md5=c72bdc7a0af499e9db6a8afccf3fa9b7

Keywords : Administration, Animals, Anti-fungal, Antifungal Agents, article, Biochemistry, chitin, Controlled release, controlled study, Corneal Diseases, Delayed-Action Preparations, drug bioavailability, Drug delivery, drug delivery system, Eye Infections, fluconazole, Fungal, Fungal infection, Fungal treatment, Fungi, Gels, human, human cell, Human dermal fibroblasts, infrared spectroscopy, keratomycosis, Nanocapsules, Nanogels, Nanostructured materials, nonhuman, Ocular drug delivery, Ophthalmic, Polyethylenes, scanning electron microscopy, Swine, Topical, treatment outcome, zeta potential

Campus : Kochi

School : Center for Nanosciences, School of Pharmacy

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Pharmacology, Nanosciences

Verified : Yes

Year : 2013

Abstract : Poor bioavailability of antifungal drugs due to the various protective mechanisms of the eye is a serious concern for the treatment of corneal fungal infections in today's world. The use of nanosystems that can improve the bioavailability of these antifungal drugs is relatively a new idea being conceived and here we have synthesized fluconazole loaded chitin nanogels (Flu-CNGs) which can be used for the treatment of corneal fungal infections. These nanogels were characterized using DLS, Zeta potential, SEM, FTIR and TG/DTA. The prepared Flu-CNGs have controlled release pattern which is ideal for the continuous availability of fluconazole over a longer period of time for an effective fungal treatment. Flu- CNGs are haemocompatible, cytocompatible and also showed very good cell uptake in human dermal fibroblast cells and penetration to the deeper sections of the porcine cornea with no signs of destruction or inflammation to corneal cells as shown in ex vivo permeation studies. Copyright © 2013 American Scientific Publishers All rights reserved.

Cite this Research Publication : N. Mohammed, N. Rejinold, S., Mangalathillam, S., Dr. Raja Biswas, Nair, S. V., Dr. Jayakumar Rangasamy, and Dr. Sabitha M., “Fluconazole Loaded Chitin Nanogels as a Topical Ocular Drug Delivery Agent for Corneal Fungal Infections”, Journal of Biomedical Nanotechnology, vol. 9, pp. 1521-1531, 2013

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