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GSH-responsive biotinylated poly(vinyl alcohol)-grafted GO as a nanocarrier for targeted delivery of camptothecin

Publication Type : Journal Article

Thematic Areas : Advanced Materials and Green Technologies

Publisher : RSC Adv.

Source : RSC Adv., vol. 6, pp. 62385-62389, 2016

Url : http://dx.doi.org/10.1039/C6RA09706E

Campus : Amritapuri, Coimbatore

School : School of Biotechnology, School of Engineering

Center : Center for Excellence in Advanced Materials and Green Technologies, Center for Industrial Research and Innovation (ACIRI)

Department : Chemical, Civil, Electronics and Communication

Year : 2016

Abstract : A water-soluble and biocompatible polymer{,} i.e. biotinylated poly(vinyl alcohol)-grafted graphene oxide (GO){,} was used as a nanocarrier for targeted delivery of anticancer drug camptothecin (CPT). The extent of CPT release in the presence of glutathione (GSH) from GO-biotinPVA-CPT was monitored by the increase in the fluorescence intensity{,} at [small lambda]max = 450 nm. The cell-specific (HeLa) antiproliferative activity of GO-biotinPVA-CPT makes it suitable to be used for targeted delivery of chemotherapeutics to cancerous cells.

Cite this Research Publication : Y. K. Yasoda, Bobba, K. Naidu, Divya Nedungadi, Dutta, D., M. Kumar, S., Kothurkar, N., Mishra, N., and Bhuniya, S., “GSH-responsive biotinylated poly(vinyl alcohol)-grafted GO as a nanocarrier for targeted delivery of camptothecin”, RSC Adv., vol. 6, pp. 62385-62389, 2016

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