Publication Type : Journal Article
Publisher : J Clin Transl Res
Source : J Clin Transl Res 2022; 8(5):9
Url : https://pubmed.ncbi.nlm.nih.gov/36212700/
Campus : Faridabad
Year : 2022
Abstract : Background and aim: Malnutrition increases risk of mortality in critically ill patients with cirrhosis. Modified Nutrition Risk in Critically ill (mNUTRIC) score is a validated tool to identify at risk patients who may benefit from goal-directed nutrition therapy. We aimed to study the association between mNUTRIC score and 28-day mortality in critically ill patients with cirrhosis.
Methods: A prospective study was conducted in the liver intensive care unit of a quaternary teaching institute. Baseline and follow-up data pertaining to mNUTRIC score, clinical, hemodynamic, biochemical, nutritional parameters, mechanical ventilation, length of ICU stay, and development of sepsis were collected. Correlation between mNUTRIC score and its modulation by nutritional adequacy was determined.
Results: One hundred and fifty patients were enrolled. Out of these, 116 (77%) had a high NUTRIC score (HNS) and 34 (23%) had a low NUTRIC score (LNS). Patients with HNS had higher mortality (54% vs. 10%; P = 0.008), longer mechanical ventilation (P = 0.02), and high incidence of sepsis (32% vs. 2.6%; P = 0.002) compared to LNS. The probability of survival increased with increase in nutritional adequacy (P < 0.01) in patients with HNS.
Conclusion: mNUTRIC score is a useful tool for identifying nutrition risk in critically ill patients with cirrhosis. Goal-directed nutrition therapy in patients with HNS can significantly improve survival.
Relevance for patients: Critically ill patients with cirrhosis who are at a higher nutritional risk as identified by the mNUTRIC score may have a better survival benefit if higher calorie and protein adequacy are achieved in the ICU.
Cite this Research Publication : Identifying critically ill patients with cirrhosis who benefit from nutrition therapy: the mNUTRIC score study.Harshita Tripathi, Jaya Benjamin*, Rakhi Maiwall, Puneet Puri, Puja Bhatia Kapoor, Varsha Shasthry, Vandana Saluja, Prashant Agrawal, Guresh Kumar, Yogendra Kumar Joshi, Shiv Kumar Sarin.J Clin Transl Res 2022; 8(5):9