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Publication Type : Journal Article
Publisher : Elsevier
Source : Tetrahedron Letters, 2015
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2015
Abstract : Acetate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one chiral auxiliary have been optimized with high yields and diastereoselectivity on various N-substituted isatins. The standardized reaction condition was employed for the stereoselective synthesis of furoindolines, and the pyrroloindole based natural products flustraminol B and N-benzyl alline.
Cite this Research Publication : Mukesh Gangar, Naresh Kashyap, Kapil Kumar, Sandeep Goyal and Vipin A. Nair, "Imidazolidinone based chiral auxiliary mediated acetate aldol reactions of isatin derivatives and stereoselective synthesis of 3-substituted-3-hydroxy-2-oxindoles", Tetrahedron Letters, 2015, 56, 7074-7081