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Immunohistochemical demonstration of mycobactrial antigens in intracranial tuberculoma

Publication Type : Journal Article

Source : Indian Journal exp Biol 1991

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Campus : Kochi

Year : 1991

Abstract : Mycobacterial antigens have been demonstrated immunohistochemically in the paraffin sections of 10 intracranial tuberculous granulomas and the results were compared with the detection of acid fast bacilli by conventional Ziehl-Neelsen method. In none of the 10 specimens, acid fast bacilli were demonstrated while mycobacterial antigens were characterised as diffusely staining granular brownish-pink material within the cytoplasm of giant cells and macrophages. In 14 specimens of granulomatous lesions due to non-tuberculous aetiology, immunohistochemical stains were negative for mycobacterial antigen. Thus demonstration of mycobacterial antigen will be not only useful in establishing mycobacterial aetiology of a caseating intracranial granuloma but also can be used as an alternative method to the conventional Ziehl-Neelsen method.

Cite this Research Publication : Radhakrishnan V.V, Annamma M, Radhakrishnan N.S. Rout D, Sehgal S. Immunohistochemical demonstration of mycobactrial antigens in intracranial tuberculoma. Indian J exp Biol 1991;29:641-644.

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