Publication Type : Conference Paper
Thematic Areas : Learning-Technologies, Medical Sciences, Biotech
Publisher : International Conference on Biotechnology for innovative applications, Amrita Vishwa Vidyapeetham, Kerala.
Source : International Conference on Biotechnology for innovative applications, Amrita Vishwa Vidyapeetham, Kerala, 2013.
Campus : Amritapuri
School : School of Biotechnology
Center : Amrita Mind Brain Center, Biotechnology, Computational Neuroscience and Neurophysiology
Department : biotechnology
Verified : Yes
Year : 2013
Abstract : Understanding population activities of underlying neurons reveal emergent behavior as patterns of information flow in neural circuits. Evoked local field potentials (LFPs) arise from complex interactions of spatial distribution of current sources, time dynamics, and spatial distribution of dipoles apart underlying conductive properties of the extracellular medium. We reconstructed LFP to test and parameterize the molecular mechanisms of cellular function with network properties. The sensitivity of LFP to local excitatory and inhibitory connections was tested using two novel techniques. In the first, we used a single granule neuron as a model kernel for reconstructing population activity. The second technique consisted using a detailed network model. LTP and LTD regulating the spatiotemporal pattern of granular layer responses to mossy fiber inputs was studied. The effect of changes in synaptic release probability and modulation in intrinsic excitability of granule cell on LFP was studied. The study revealed cellular function and plasticity were represented in LFP wave revealing the activity of underlying neurons. Changes to single cell properties during LTP and LTD were reflected in the LFP wave suggesting the sparse recoding function of granule neurons as spatial pattern generators.
Cite this Research Publication : Harilal Parasuram, Dr. Bipin G. Nair, and Dr. Shyam Diwakar, “Implications of algorithms on LFP reconstruction in cerebellar granular layer”, in International Conference on Biotechnology for innovative applications, Amrita Vishwa Vidyapeetham, Kerala, 2013.