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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : International Journal of Pharmacy and Pharmaceutical Sciences
Source : International Journal of Pharmacy and Pharmaceutical Sciences, Volume 5, Number SUPPL 3, p.819-823 (2013)
Keywords : 1, 1 diphenyl 2 picrylhydrazyl, Aegle, Aegle tamilnadensis, Aegle tamilnadensis extract, antioxidant activity, article, chelation, flavanoid, fluorescence analysis, hydroxyl radical, nonhuman, phenol, plant extract, plant leaf, superoxide, unclassified drug
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2013
Abstract : Objective: The present study was aimed to find out antioxidant property of methanolic and aqueous extracts of Aegle tamilnadensis Abdul Kader (Rutaceae) leaf. Methods: The phenolic and flavanoid contents of methanolic and aqueous extract were determined. The antioxidant potential of the leaf samples was evaluated by using five in vitro assays such as 2, 2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical, superoxide radical, reducing power and metal ion chelating assays. Results: The phenol and flavanoid contents were found to present in considerable quantities. The methanolic leaf extract showed better ability to scavenge superoxide radical (IC50 value of 50.50±0.84μg /ml) followed by hydroxyl radical (IC50 value of 232.95±1.10μg/ml). It also showed good reducing power ability. In contrast, 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radicals were effectively scavenged by aqueous leaf extract (IC50 value of 82.05±1.02 μg/ml). Both the methanolic and aqueous leaf extracts of A. tamilnadensis leaves at 1000 μg/ml showed maximum scavenging activity (91.01% and 95.67%) in quenching metal ions. Conclusions: The results obtained from the present study indicated that the A. tamilnadensis leaf extract is a potent source of natural antioxidants and both the aqueous and methanolic leaf extracts possessed antioxidant property. However methanolic leaf extract showed better antioxidant activity than the aqueous leaf extract.
Cite this Research Publication : P. R. Chandran, Vysakhi, M. V., Manju, S., Kannan, M., S. Kader, A., and A. Nair, S., “In vitro free radical scavenging activity of aqueous and methanolic leaf extracts of Aegle tamilnadensis Abdul Kader (Rutaceae)”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 5, pp. 819-823, 2013.