ProgramsView all programs
From the news
- Chancellor Amma Addresses the Parliament of World’s Religions
- Amrita Students Qualify for the European Mars Rover Challenge
Publication Type : Journal Article
Publisher : Journal of Oral and Maxillofacial Pathology
Source : Journal of Oral and Maxillofacial Pathology, Volume 15, Number 1, p.46-51 (2011)
Campus : Kochi
School : School of Dentistry
Department : Oral & Maxillofacial Pathology and Microbiology
Year : 2011
Abstract : Neurofibromatosis-1 (NF-1) is a relatively common autosomal dominant disease characterized by multiple cutaneous fibromatoses and café au lait spots. It is associated with the mutation of NF-1 gene, a tumor suppressor gene located on chromosome 17q11.2. Hence, it can be considered as a familial cancer predisposition syndrome in which the affected individuals are at increased risk of developing malignancies. Intraoral neurofibromas associated with NF-1 are quite common, but the occurrence of malignant peripheral nerve sheath tumor (MPNST) in the oral cavity is very rare. Oral MPNST can occur either de novo or by malignant transformation of neurofibromas or very rarely can represent a metastatic lesion. Here, we present a case of MPNST involving the maxillary region, in a patient with NF-1. Since MPNST often creates a diagnostic dilemma, histopathologic criteria for the diagnosis of MPNST are also discussed.
Cite this Research Publication : M. Janardhanan, Dr. Rakesh S., and Kumar, R. B. V., “Intraoral presentation of multiple malignant peripheral nerve sheath tumors associated with neurofibromatosis-1”, Journal of Oral and Maxillofacial Pathology, vol. 15, pp. 46-51, 2011.