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Long-term Drug Delivery using Implantable Electrospun Woven Polymeric Nanotextiles

Publication Type : Journal Article

Thematic Areas : Medical Sciences, Nanosciences and Molecular Medicine

Publisher : Nanomedicine: Nanotechnology, Biology, and Medicine

Source : Nanomedicine: Nanotechnology, Biology, and Medicine, Volume 15, Issue 1, p.274-284 (2019)

Keywords : Animals, Antineoplastic Agents, Phytogenic, cell proliferation, Cells, Cultured, Drug Carriers, Drug Delivery Systems, Drug Implants, Drug Liberation, Mice, Mice, Inbred BALB C, Nanostructures, paclitaxel, peritoneum, Polymers, Textiles, tissue distribution

Campus : Kochi

School : Center for Nanosciences, School of Medicine

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine, Medical Oncology

Year : 2019

Abstract : A woven nanotextile implant was developed and optimized for long-term continuous drug delivery for potential oncological applications. Electrospun polydioxanone (PDS) nanoyarns, which are twisted bundles of PDS nanofibres, were loaded with paclitaxel (PTX) and woven into nanotextiles of different packing densities. A mechanistic modeling of in vitro drug release proved that a combination of diffusion and matrix degradation controlled the slow PTX-release from a nanoyarn, emphasizing the role of nanostructure in modulating release kinetics. Woven nanotextiles, through variations in its packing density and thereby architecture, demonstrated tuneable PTX-release. In vivo PTX-release, pharmacokinetics and biodistribution were evaluated in healthy BALB/c mice by suturing the nanotextile to peritoneal wall. The slow and metronomic PTX-release for 60 days from the loosely woven implant was extremely effective in enhancing its residence in peritoneum, in contrast to intraperitoneal injections. Such an implantable matrix offers a novel platform for therapy of solid tumors over prolonged durations

Cite this Research Publication : S. Padmakumar, Dr. Bindhu Paul, Pavithran, K., Vijaykumar, D. Kottarathi, Rajanbabu, A., Sivanarayanan, T. Balakrishn, Kadakia, E., Amiji, M. M., Shantikumar V Nair, and Dr. Deepthy Menon, “Long-term Drug Delivery using Implantable Electrospun Woven Polymeric Nanotextiles”, Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 15, no. 1, pp. 274-284, 2019.

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