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Mitochondria-specific visible-light sensitized europium complex with impressive red emission

Publication Type : Journal Article

Publisher : Dalton Trans

Source : Dalton Trans 42(34)12317-12323

Url : https://www.researchgate.net/publication/249320970_A_mitochondria-specific_visible-light_sensitized_europium_b-diketonate_complex_with_red_emission

Campus : Amritapuri

School : School of Biotechnology

Center : Biotechnology

Department : biotechnology

Verified : Yes

Year : 2013

Abstract : Our recently developed Eu(3+) coordination compound, Eu(pfppd)3(tpy) [where Hpfppd = 4,4,5,5,5-pentafluoro-3-hydroxy-1-(phenanthren-3-yl)pentanedione and tpy = 2,2':6,6''-terpyridine] exhibits significant quantum yield (Φoverall = 41%) and long (5)D0 lifetime (880 μs) values under biologically relevant pH conditions (pH = 7.4) when excited with visible light. Hence, the Eu(3+) luminescent complex was examined for live cell imaging using the rat embryonic heart cell line, H9c2. The ternary Eu(3+) complex permeates into the H9c2 cells and co-localises with the mitochondria, as demonstrated by counterstaining experiments. Furthermore, the designed Eu(3+) bioprobe remains undissociated in the cell medium, showed a good cell permeability and a fast cellular uptake with a specific localization profile. Thus it has the potential to become a time-resolved imaging probe that is excitable in the visible-light range.

Cite this Research Publication : Mitochondria-specific visible-light sensitized europium complex with impressive red emission (2013) Divya V, Sankar V, Raghu KG and Reddy MLP Dalton Trans 42(34)12317-12323 (IF 4.39)

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