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Publication Type : Journal Article
Publisher : Journal of Biologically Active Products from NatureJournal of Biologically Active Products from Nature, Taylor & Francis
Source : Journal of Biologically Active Products from NatureJournal of Biologically Active Products from Nature, Taylor & Francis, Volume 10, Issue 5, p.373 - 378 (2020)
Url : https://www.tandfonline.com/doi/abs/10.1080/22311866.2020.1838947
Keywords : ACE, Ang-II, Large cardamom, vasodilatation
Campus : Kochi
School : School of Pharmacy
Department : Pharmacognosy
Year : 2020
Abstract : Abstract Hypertension is a growing public health concern due to its high prevalence all around the globe. Spices and herbs are known to possess antihypertensive activities. Hence, we evaluated the therapeutic potential of large cardamom (Amomum subulatum Roxb family Zingiberaceae) in hypertension using in-vitro and in-silico methods. In our in vitro studies, the aqueous extract of large cardamom exhibited concentration-dependent angiotensin-converting enzyme inhibitory and angiotensin II antagonistic activity. In silico molecular docking study showed that among the six constituents, protocatechuic acid and alpinetin possessed high-affinity binding with the target site than the standard used. Our results show evidence that aqueous extract of large cardamom can improve vascular function. Further experimental studies are required to better elucidate the possible mechanisms behind the antihypertensive activity of large cardamom.
Cite this Research Publication : V. S. Arya, Kanthlal, S. K., Prasanth, B. Paul, Vijayakumar, M., Nair, K. R., and P. Devi, U., “Modulation of Renin-Angiotensin System by Aqueous Extract of Large Cardamom: In vitro and in silico Studies”, Journal of Biologically Active Products from NatureJournal of Biologically Active Products from Nature, vol. 10, no. 5, pp. 373 - 378, 2020.