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Publication Type : Journal Article
Publisher : Bentham Science Publishers
Source : Current Pharmaceutical Design, Bentham Science Publishers, 2021, 27(34), pp. 3591-3601
Url : 10.2174/1381612826666201112144006
Campus : Kochi
School : School of Pharmacy
Department : Pharmaceutical Chemistry & Analysis
Year : 2021
Abstract : Neurodegeneration is a multifactorial process involved the different cytotoxic pathways that lead to neuronal cell death. Alzheimer’s disease (AD) is a persistent neurodegenerative disorder that normally has a steady onset and gradually worsens. Neuropathology, AD is characterized by the presence of neuroinflammation, mitochondrial dysfunction, increased oxidative stress, decreased antioxidant defense as well as increased acetylcholinesterase activity. Moreover, enhanced expression of amyloid precursor proteins leads to neural apoptosis, which has a vital role in the degeneration of neurons. The inability of commercial therapeutics to treat a single feature of AD pathology leads to the attraction towards organic drugs. Ellagic acid is a dimer of gallic acid; latest studies revealed that ellagic acid can initiate numerous cell signaling transmissions and decrease the progression of neurodegeneration. The neuroprotective effects of ellagic acid to protect the neurons against neurodegenerative events are due to its antioxidant effect, iron chelating, and mitochondrial protective effect. The main goal of this review is to critically analyze the molecular mechanism of action of ellagic acid against AD.
Cite this Research Publication : N. Javaid, Shah, M. Ajmal, Rasul, A., Chauhdary, Z., Saleem, U., Khan, H., Ahmed, N., Uddin, M. Sahab, Bijo Mathew, Behl, T., and Blundell, R., “Neuroprotective Effects of Ellagic Acid in Alzheimer's Disease: Focus on Underlying Molecular Mechanisms of Therapeutic Potential.”, Current Pharmaceutical Design, Bentham Science Publishers, 2021, 27(34), pp. 3591-3601