Publication Type : Journal Article
Publisher : Materials Today: Proceedings,
Source : Materials Today: Proceedings, vol. 5, pp. 17812 - 17819, 2018
Url : https://www.sciencedirect.com/science/article/pii/S2214785318312161
Keywords : clopidogrel, clopidogrel-tetraidobismuthate, potentiometry, PVC membrane sensor
Campus : Amritapuri
School : School of Arts and Sciences
Center : Research & Projects
Department : Programs and Research, Chemistry
Verified : Yes
Year : 2018
Abstract : This paper describes the fabrication of potentiometric PVC membrane for clopidogrel bisulphate and its successful utilization in the determination clopidogrel from clopilet tablet. Effect of PVC membrane matrix were studied and optimized membrane composition which ensued a Nernstian slope of 58.83±0.340mV/decade was found to be PVC 32%, ion association 3%,NaTBP 2% and DBP 63 % respectively. Sensor revealed a fast response time of 3s in the concentration range 1×10-2 -1×10-6 M with a lower detection limit of 9.12 ×10-7M. Working pH range and response time was found to be 2.0 - 4.5 and 5s respectively. Comparative studies on the various parameters that depend on the potential response of the present sensor with that of the literature reports were also included
Cite this Research Publication : A. Santhy, Dr. Beena S., P. Sankar, U., Vidya, R., and Rejithamol, R., “PVC membrane Sensor Immobilized with Clopidogrel-Tetraiodo Bismuthate for the Potentiometric Determination of Clopidogrel from Pharmaceutical Formulations”, Materials Today: Proceedings, vol. 5, pp. 17812 - 17819, 2018
