Publication Type : Journal Article
Thematic Areas : Biotech
Publisher : Bioorganic Medicinal Chemistry
Source : Bioorganic & Medicinal Chemistry, Volume 23, Number 13, p.3781 - 3787 (2015)
Url : http://www.sciencedirect.com/science/article/pii/S0968089615002916
Keywords : MMP-2 and MMP-9
Campus : Amritapuri, Coimbatore
School : School of Physical Sciences, School of Biotechnology
Center : Biotechnology, Cell Biology, Phytochemistry Labs
Department : Department of Sciences, biotechnology
Year : 2015
Abstract : Abstract Eleven biflavones (7a–b and 9a–i) were synthesised by a simple and efficient protocol and screened for MMP-2 and MMP-9 inhibitory activities. Amongst them, a natural product-like analog, (I-3,II-3)-biacacetin (9h) was found to be the most potent inhibitor. Molecular docking studies suggest that unlike most of the known inhibitors, 9h inhibits MMP-2 and MMP-9 through non-zinc binding interactions.
Cite this Research Publication : Pandurangan Nanjan, Dr. Jyotsna Nambiar, Dr. Bipin G. Nair, and Dr. Asoke Banerji, “Synthesis and Discovery of (I-3,II-3)-Biacacetin as a Novel Non-zinc Binding Inhibitor of MMP-2 and MMP-9”, Bioorganic & Medicinal Chemistry, vol. 23, pp. 3781 - 3787, 2015