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Synthesis, Characterisation and Biomedical Applications of Curcumin Conjugated Chitosan Microspheres.

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : International Journal of Biological Macromolecules, Elsevier B.V.

Source : International Journal of Biological Macromolecules, Elsevier B.V., Volume 10, Issue 11, p.1-7 (2017)

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Keywords : Animals, Anti-Bacterial Agents, Antioxidants, chitosan, curcumin, Drug Delivery Systems, Escherichia coli, Mice, Microspheres, NIH 3T3 Cells, Staphylococcus aureus

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2018

Abstract : Curcumin is a diaryl heptanoid of curcuminoids class obtained from Curcuma longa. It possesses various biological activities like anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities. Chitosan is a biocompatible, biodegradable and non-toxic natural polymer which enhances the adhesive property of the skin. Chemical conjugation will leads to sustained release action and to enhance the bioavailability. This study aims to synthesis and characterize biocompatible curcumin conjugated chitosan microspheres for bio-medical applications. The Schiff base reaction was carried out for the preparation of curcumin conjugated chitosan by microwave method and it was characterised using FTIR and NMR. Curcumin conjugated chitosan microspheres (CCCMs) were prepared by wet milling solvent evaporation method. SEM analysis showed these CCCMs were 2-5μm spherical particles. The antibacterial activities of the prepared CCCMs were studied against Staphylococcus aureus and Escherichia coli, the zone of inhibition was 28mm and 23mm respectively. Antioxidant activity of the prepared CCCMs was also studied by DPPH and HO method it showed IC esteem value of 216μg/ml and 228μg/ml, and anti-inflammatory activity results showed that CCCMs having IC value of 45μg/ml. The results conclude that the CCCMs having a good antibacterial, antioxidant and anti-inflammatory activities. This, the prepared CCCMs have potential application in preventing skin infections.

Cite this Research Publication : T. S. Saranya, Rajan, V. K., Biswas, R., Dr. Jayakumar Rangasamy, and Sathianarayanan, S., “Synthesis, Characterisation and Biomedical Applications of Curcumin Conjugated Chitosan Microspheres.”, Int J Biol Macromol, vol. 110, pp. 227-233, 2018.

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