• Wound healing is the result of a complex interplay between various cell types wherein macrophages and fibroblasts play a crucial role during various phases of the process.

    identification-of-natural-product-lead-molecules-as-potential-modulators-of-wound-healing-and-elucidation-of-the-underlying-molecular-mechanisms
  • Diabetes is a chronic disorder characterized by abnormal blood glucose levels due to problems associated with insulin production and action. When glucose levels rise too high, diabetes becomes dangerous. Without medical care, it can increase the risk of heart disease and stroke and in late stages can cause blindness, kidney failure and loss of limbs.

    amrita-insulin-pump-and-low-cost-automated-biomedical-devices
  • Oxidative stress refers to the physiological stress caused by an imbalance between the systemic production of reactive oxygen species and the biological system's ability to detoxify the reactive intermediates. It is a condition where the system lacks its ability to repair the damage due to oxidative stress and thus leading to a number of diseases.

    mass-spectrometry-based-proteomic-characterization-of-carbonylated-proteins-as-indicators-of-oxidative-stress
  • The joint effort by Amrita and Wipro has the goal of making diabetes care available, accessible and affordable for the Indian masses. Amrita and Wipro has envisaged a patient-centric solution wherein low cost diabetes care devices (glucose strips, glucometers & insulin pumps) will interact with users through mobile applications using the cloud gateway. Innovative features of the device will make diabetes management easier for Indian patients and physicians.

    cost-effective-device-and-cloud-enabled-smart-solution-for-diabetes-care
  • Benzophenanthridines, naturally occurring isoquinoline alkaloids with various biological activities, are known to exist in five plant families, namely, the Fumariaceae (Genera Corydalis, Dicentra and Fumaria), the Papaveraceae, and the Rutaceae. Members of this family are generally investigated for potential biological activities.

    synthesis-of-modified-benzophenanthridine-a-preliminary-anti-cancer-study
  • Inflammation is the body's endeavor at self-defense, the intent being to eradicate harmful stimuli, including damaged cells, irritants, or pathogens and begin the healing process.  It is one of the major steps in normal wound healing process with overlapping events such as formation of granulation tissue, angiogenesis, and tissue remodeling. However, chronic inflammation can also lead to a host of diseases.

    regulation-of-inflammation-by-natural-product-extracts-role-in-osteoclastogenesis
  •  The lack of effective “in vitro” models to predict success of pharmacological therapy for patients with variety of cancer cell types demands the development of better experimental models to understand the pathophysiology of the disease and evaluate drug sensitivity in vitro. Cell lines are well characterized homogenous population that gives consistent and reproducible result from experiment to experiment. Many of these cell lines were established over 20 years ago.

    isolation-and-characterization-of-primary-tumor-cells
  • The focus of the project is to screen molecules with anti-cancer properties and understand their mode of action with respect to cell death. Many cancer cells are apoptosis resistant; we are trying to target them by an alternative cell death pathway known as “paraptosis” or cytoplasmic vacuolation mediated cell death.

    paraptosis-a-newer-approach-to-target-cancer
  • Plant diseases caused by bacteria and fungi are the major reasons for significant loss in crop yields. To address this issue, many strategies have been developed and new bioanalytical tools have been utilized with an aim to control microbe derived diseases.

    mass-spectrometric-characterization-of-bioactive-peptides-and-proteins
  • Typically, a snake bite is treated with polyclonal antibody preparations obtained from immunized animals. This method is suboptimal because the neutralizing agents are not tailored towards specific venom components and because of batch variability due to turnover of venom donor and antivenom donor animals.

    peptide-based-anti-snake-venom-therapy
  • Tuberculosis (TB) is believed to affect nearly one third of the world population with approximately 9 million new cases detected every year. Current methods of diagnosis includes sputum smear microscopy, chest X-Ray and biopsy which are time consuming and expensive with a low level of accuracy.

    design-and-validation-of-point-of-care-disposable-sensor-strips-for-diagnosis-of-tuberculosis-from-urine-samples
  • Apart from the various alternatives of conventional energy sources, electricity generated by microorganisms can be an important source of renewable energy. The Microbial Fuel Cell (MFC) which harnesses this potential, offers possibilities of extracting energy from a wide range of substrates from complex organic wastes to inorganic carbon dioxide.

    development-of-heterotrophic-and-phototrophic-microbial-fuel-cell
  • iabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has serious drawbacks like insufficient long-term stability, which originates from the intrinsic nature of the enzymes. This project aims at development and fabrication of non-enzymatic glucose sensor and a glucometer.

    development-and-fabrication-of-non-enzymatic-electrochemical-glucose-biosensor-and-fabrication-of-glucometer
  • Endothelium helps in maintaining vascular tone by regulating the vascular permeability. It selectively allows only certain molecules to cross the endothelial barrier. A large number of micro and macro vascular complications are associated with endothelial dysfunction in diabetes including cardiovascular disease, stroke and peripheral vascular diseases.

    natural-products-as-modulators-of-diabetes-associated-endothelial-dysfunctions
  • It is seen that therapies for diabetes and heart disease affects liver and these diseases are increasing in prevalence especially in developing countries. The liver metabolises and detoxifies drugs and substances that are harmful to the body as well as produces blood clotting factors, proteins, and enzymes and helps maintain hormone balances, and stores vitamins and minerals.

    affordable-paper-based-microfluidics-point-of-care-testing-device-for-liver-function

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