| Course Name | CRISPR/Cas9 Technology |
| Course Code | 23AID442 |
| Program | B.Tech in Artificial Intelligence and Data Science |
| Credits | 3 |
| Campus | Coimbatore , Amritapuri ,Faridabad , Bangaluru, Amaravati |
Introduction to Genetic Engineering – History of Crispr – Crispr in bacteria – Classification of Crispr – General structure of cas9 protein – Mechanism of Crispr cas9 – Applications – Database of Crispr – Case studies.
Course Objectives
Course Outcomes
After completing this course, students will be able to
|
CO1 |
Analyze and learn the discovery of Crisper with emphasis to molecular mechanisms. |
|
CO2 |
Apply the basic concepts on various application of gene therapy. |
|
CO3 |
Design familiar with experimental design. |
|
CO4 |
create automated pipelines for identifying the associations between multiple genome editions. |
CO-PO Mapping
|
PO/PSO |
PO1 |
PO2 |
PO3 |
PO4 |
PO5 |
PO6 |
PO7 |
PO8 |
PO9 |
PO10 |
PO11 |
PO12 |
PSO1 |
PSO2 |
PSO3 |
|
CO |
|||||||||||||||
|
CO1 |
3 |
3 |
3 |
2 |
3 |
3 |
3 |
3 |
3 |
3 |
3 |
||||
|
CO2 |
3 |
3 |
3 |
2 |
3 |
3 |
3 |
3 |
3 |
3 |
3 |
2 |
|||
|
CO3 |
3 |
3 |
3 |
2 |
3 |
3 |
3 |
3 |
3 |
3 |
3 |
2 |
|||
|
CO4 |
3 |
3 |
3 |
2 |
3 |
3 |
3 |
3 |
3 |
3 |
2 |
3 |
Evaluation Pattern
|
Assessment |
Internal/External |
Weightage (%) |
|
Assignments (Minimum 2) |
Internal |
30 |
|
Quizzes (Minimum 2) |
Internal |
20 |
|
Mid-Term Examination |
Internal |
20 |
|
Term Project/ End Semester Examination |
External |
30 |
Textbooks / References
Maximilian Haeussler, Jean-Paul Concordet, CRISPOR Manual, MIT, 2016. Singh et al: A Mouse Geneticist’s Practical Guide to CRISPR Applications; Genetics, Vol.199, No.1, 2015.
Ran et al, Genome engineering using the CRISPR-Cas9 system, Nature Protocols, 2013.
Fujihara&Ikawaw, CRISPR/Cas9-Based Genome Editing in Mice by Single Plasmid Injection, Methods Enzymol. 2014.
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