Qualification: 
M. Pharm.
roshnipr@aims.amrita.edu

Roshni P. R. joined as Senior Lecturer in the Department of Pharmacy Practice, Amrita School of Pharmacy in September 2010. Currently she serves as Assistant Professor in the department of Pharmacy Practice. She has about 13 years of teaching experience and has more than 20 national and international publication to her credit. Her main area of interests are Diabetic Science, Obesity and Pharmacoepidemiological studies. She has guided many Pharm D and M. Pharm projects and two of her research projects were funded by Kerala State Council for Science and Technology.

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2017

Journal Article

J. Karakkattu and Roshni P. R., “Etiology for liver diseases in pediatric population”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 91-94, 2017.[Abstract]


Objective: The liver diseases affect both the pediatric and adult populations. In the adult population, the stereotype diagnosis in the Indian population is targeted toward males due to excessive alcoholic consumption. Nevertheless, the liver diseases can also affect both the female and pediatric populations. Pediatric liver diseases include cirrhosis, fatty liver diseases, and hepatic failure. The liver diseases are commonly caused by biliary atresia and genetic metabolic diseases. In children, the signs and symptoms of liver diseases are dependent on the principal reason of the liver disease. This review article is to cover all the etiologies that have been identified to cause liver diseases with a special focus on pediatric acute liver failure. Methods: An extensive PubMed search was conducted and articles that were published after 2007 were included in this article. Results: The pediatric population etiology of liver diseases can be broadly categorized into infections, immunologic, metabolic, toxin or drug related, indeterminate, and diseases resulting in liver cirrhosis. Complications of pediatric liver diseases include malnutrition, infection, gastroesophageal varices, and hepatic encephalopathy. Conclusion: Overall, the etiology for liver diseases in the pediatric population is many. Early identification of these factors can improve the quality of life of the pediatric patient. With the correct diagnostic parameters and treatment certain conditions can be completely cured. As for those whose effective treatment is still lacking it is essential to continue the ongoing research until the missing pieces have been identified. © 2017 The Authors.

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2017

Journal Article

P. S, Kumar, N. M., and Roshni P. R., “A case report on red man syndrome”, National Journal of Physiology Pharm Pharmacol, vol. 7, no. 10, pp. 1135-1136, 2017.[Abstract]


Vancomycin is a glycopeptide antibiotic used for the treatment of serious infections caused by Gram-positive organism. Rapid infusion-related adverse drug reaction (ADR) of vancomycin is known as red man syndrome (RMS) or red neck syndrome. The manifestations of RMS are erythema, flushing, pruritis of the face, upper torso, and in severe cases dyspnea, chest pain, and hypotension. RMS occurs due to the release of histamine from degranulated mast cells and basophils. This histamine release is also associated with ciprofloxacin, amphotericin B, rifampicin, and teicoplanin. It can be prevented by slowing the infusion rate or pre-treatment with an H1- or H2-receptor antagonist.

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2017

Journal Article

M. Mathew, Thomas, P., Kumar, N. M., and Roshni P. R., “Winchester syndrome: A case report and literature review”, 1992, vol. 74, 2017.[Abstract]


The mucopolysaccharidoses are a group of inherited lysosomal storage diseases that are caused by a deficiency of specific enzymes. The acid mucopolysaccharides are stored in tissue and excreted in large quantities in the urine. The storage of this material leads to effects on a wide variety of tissues and to remarkable changes in morphologic features. Winchester syndrome is a rare disorder in the group of mucopolysaccharidoses. This article is a report of a case with classic clinical, radiologic, and biochemical characteristics of the Winchester syndrome. More »»

2017

Journal Article

D. S. Raju, Sudhindran, S., and Roshni P. R., “A case series on Simultaneous Pancreas Kidney transplantation”, International Journal of Pharmaceutical Sciences Review and Research, vol. 44, no. 1, pp. 27-29, 2017.[Abstract]


Simultaneous pancreas kidney transplantation (SPK) performed as the universal treatment for patients who have type 1 diabetes mellitus and ESRD. Here we present a case series of 4 SPK cases, successfully performed. Successful SPK transplantation increase patient survival enhances quality of life, and decline diabetic complications. Suitability of SPK transplantation is dependent upon patient selection including their age and comorbidities. All patients received transplanted organ from cadaveric donor. This article discusses with immunosuppression consists of induction and maintenance therapy. Allograft dysfunction is a serious issue, after transplantation of kidney. Management of ACR and AMR has been discussed in the fourth case.

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2017

Journal Article

Roshni P. R., P.C, S. Keerthana, and Raj, K. Priya, “Steroid Induced Hypokalemia - A Case Report”, International Journal of Pharmaceutical Sciences Review & Research. , vol. 42, no. 1, pp. 42-43, 2017.[Abstract]


Prednisolone (Wysolone) is steroid. Prednisolone comes under Corticosteroid class of drug with highly Glucocorticoid activity and low Mineralocorticoid property. This property makes it useful for the treatment of different types of Inflammatory as well as AutoImmune conditions. Prednisolone prevents inflammation by limiting the rate of protein synthesis, Suppressing migration of PMN, Fibroblast and also reversing the Capillary Permeability. Herein we are presenting a Case Report of Prednisolone induced Hyokalemia.
Keywords: Prednisolone, Hypokalemia, Inflammation, Steroid.

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2017

Journal Article

M. Mathew, Thomas, P., Roshni P. R., and Kumar, N. M., “A case report on Winchester syndrome”, National Journal of Physiology, Pharmacy and Pharmacology, vol. 7, no. 10, pp. 1137-1138, 2017.[Abstract]


Winchester syndrome is a rare inherited disease characterized by severe osteolysis particularly in the hands and feet, generalized osteoporosis and absence of subcutaneous nodules. It is a group of hereditary metabolic diseases in which certain enzymes are lacking or defective that would normally break down molecules into smaller units, which leads to the accumulation of molecules in cells and tissues. A middle-aged female who is a known case of Juvenile inflammatory arthritis presented with complaints of deformities in hands, feet, knees, and hip joints. She was short stature and the random of motion of her ankle, knee, and hip was restricted. Winchester syndrome is an extremely rare disorder inherited as an autosomal recessive trait. Winchester syndrome is caused by an alteration in a gene called MMP2. Symptomatic treatment can be given with anti-inflammatory drugs and skeletal muscle relaxants. Physical therapy may be advised as a supportive measure to improve the functioning of affected limbs. Genetic counseling on the basis of the inheritance of this disease may be beneficial. Our patient was symptomatically managed with anti-inflammatory drugs and discharged with calcium supplements. Furthermore, regular physiotherapy and replacement surgeries for joints were done. This syndrome was first diagnosed in 1969; only a few cases have been reported in the medical literature till now.

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2016

Journal Article

Aa Purushothaman, Kumar, Gb, Gangadharan, Pc, and Roshni P. R., “A comparison of leuprolide acetate versus bilateral orchiectomy for patients with metastatic prostate cancer”, Asian Journal of Pharmaceutical and Clinical Research, vol. 9, pp. 51-54, 2016.[Abstract]


Objective: Prostate cancer is the most common visceral malignancy and leading cause of cancer-related death in men. Androgen deprivation therapy is the established treatment of metastatic prostate cancer and has different approaches in the reduction of androgen activity including surgical castration (bilateral orchiectomy) and medical castration (luteinizing hormone-releasing hormone agonists/antagonists). Our purpose was to study the clinical profile, effectiveness, and outcome of South Indian patients with metastatic prostate cancer undergoing treatment with surgical and medical castration. Methods: A total of 30 surgical and 30 medical castration patients diagnosed with metastatic prostate cancer between (2008 and 2009) were followed up to 5 years. Serum prostate specific antigen (PSA) levels at the time of the first diagnosis, post-treatment nadir PSA levels, time to nadir PSA, time to hormonal resistance between the study groups were assessed, retrospectively. The Kaplan–Meier method was used with log-rank test for survival rate calculations. Gleason score, PSA levels, skeletal-related events, and sites of metastasis of the study groups were studied. Result: The average survival time after medical castration was 60 months and 42 months for surgical castration. No significant difference could be established between the groups. Bone was the most common site of metastasis and radiation was the major skeletal-related events in medical groups. Conclusion: There were no statistical differences between the groups in terms of treatment modalities in metastatic prostate cancer. © 2016, Innovare Academics Sciences Pvt. Ltd. All rights reserved.

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2015

Journal Article

Remya Reghu, Keerthana, P. C. Sai, Das, A., M, N. C., Joseph, T., Meenu Vijayan, and Roshni P. R., “A case report on carbimazole induced myositis”, International Journal of Pharmaceutical Sciences Review and Research, vol. 32, pp. 268-269, 2015.[Abstract]


Carbimazole is an anti-thyroid drug commonly used to treat hyperthyroidism. Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T 4. Here we are presenting a case report of carbimazole induced myositis © 2015, Global Research Online. All rights reserved.

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2014

Journal Article

Roshni P. R., Thomas, N. R., Remya Reghu, and Meenu Vijayan, “Application of pharmacogenomics in health care”, International Journal of Pharmaceutical Sciences Review and Research, vol. 26, pp. 131-133, 2014.[Abstract]


Pharmacogenomics is the study of how genetic factors relate to inter-individual variability of drug response. With the initiation of Human Genome Project on 1991, it will have an important effect on the development and utilization of drug which is based on the person's genotype that ensure the rational use of medicine. The pharmacokinetic and pharmacodynamic characters of the drug may influenced by various genetic factors, so the effect of a drug may vary from person to person. Genetic polymorphism of single gene affect a numerous drug metabolizing enzymes, thus leads to altered drug metabolism and produce adverse effects or inefficiency. It has relevance in case of population carries genetic variation-polymorphism that may alter the drug response such as in the case of warfarin. A reduction in warfarin metabolism due to genetic polymorphism in CYP2C9 system may explain the increased warfarin response and bleeding episodes in some patients. The impact of genetic polymorphism has bee also important in case of drugs which are metabolized through CYP2D6 subfamily, such as codeine, nortriptyline, metoprolol, simvastatin, abacavir, carbamazepine, selective serotonin reuptake inhibitors and tamoxifen. This review is mainly focused on the importance of pharmacogenomic testing for certain drugs.

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2013

Journal Article

R. Reghu, Meenu Vijayan, and Roshni P. R., “Procurement and distribution of medicines in government hospitals of Tamil Nadu - An overview”, International Journal of Research in Pharmaceutical Sciences, vol. 4, pp. 96-100, 2013.[Abstract]


It is an established truth that the drug availability in the Indian public health system is always remaining as a prob-lem. One can attribute many reasons like shortage of fund, inefficient indenting procedures, poor inventory man-agement and others for the problem. Recognizing the shortage of medicines in government hospitals, many Indian states have introduced exclusive set ups for the purchase of medicines for the hospitals. They procure medicines through centralized pooled purchases. Kerala, Delhi, and Tamil Nadu governments were introduced such pooled procurement system for drug purchase. Tamil Nadu, a major state in India started a corporation styled as Tamil Nadu Medical Service Corporation (TNMSC) registered under the Companies Act 1956 in July 1994. With the help of a well-designed and scientifically planned scheme TNMSC could introduce many innovations and thereby revo-lutionize the public drug procurement system in the country. Articles about the drug purchase systems followed in hospitals are rare. In this article mainly focusing the procurements methods adopted by the Tamil Nadu State. ©JK Welfare & Pharmascope Foundation.

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2012

Journal Article

A. S, Lakshmi R., Cherian, S., and Roshni P. R., “Maternal hypothyroidism – a clinical perspective”, International Journal of Medical and Pharmaceutical Sciences, 2012.[Abstract]


Maternal hypothyroidism, in simple terms, refers to low thyroid hormone levels during pregnancy. The diagnosis is made by a TSH that is greater than normal, and this situation deserves therapy. Many studies have shown that maternal thyroid hormones are very important in pregnancy1-3. Most importantly, emerging data seems to suggest that thyroid hormones are especially important for fetal brain development, especially during early pregnancy4. This article will discuss the importance, diagnosis and management of maternal hypothyroidism, from a clinician’s perspective.

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Faculty Research Interest: 
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