Back close

Proteasome inhibitors from natural products

School: School of Biotechnology

Project Incharge:Dr. Nandita Mishra
Proteasome inhibitors from natural products

The ubiquitin-proteasome system (UPS) plays an essential role in many cellular processes, including cell cycle progression, proliferation, apoptosis and angiogenesis. Proteasome inhibitors like Bortezomib (Velcade, PS-341), has been successfully used as anticancer drug. Several natural compounds, including the green tea polyphenols, microbial metabolite lactacystin and many triterpenes have been shown to be potent proteasome inhibitors. One of our ongoing project is to screen novel proteasomal inhibitors from natural products that induce cell death in cancer cells.

Related Projects

VALUE Virtual Simulation Labs
VALUE Virtual Simulation Labs
Determination of Antibacterial Activity of Different Spices Against E.coli
Determination of Antibacterial Activity of Different Spices Against E.coli
Bioapproach: Synthesis of Silver Nanoparticles from Mangrove Endophytes
Bioapproach: Synthesis of Silver Nanoparticles from Mangrove Endophytes
Development of Heterotrophic and Phototrophic Microbial Fuel Cell
Development of Heterotrophic and Phototrophic Microbial Fuel Cell
Expression and refolding of Recombinant Staphylococcal Amidases in E. Coli
Expression and refolding of Recombinant Staphylococcal Amidases in E. Coli
Admissions Apply Now