In the ongoing battle to combat antimicrobial resistance (AMR), we are investigating two promising avenues: natural products and bacteriophages. Natural products such as essential oils are known to interfere with quorum sensing, a cell-to-cell communication system known to regulate virulence. These quorum sensing inhibitors can therefore attenuate virulence without killing the bacteria. Additionally, these compounds can also modulate the immune response of the host making them very good anti-infectives. Furthermore, since the survival of the pathogen is not at stake, chances of decelopment of resistance are also very minimal.
Another important area of research is focused on isolation and characterization of lytic phages targeting the WHO classified critical priority ESKAPE-pathogens. These phages as well as phage cocktails will be formulated to assess the efficacy with which they can sensitize and kill MDR pathogens. Combinatorial studies using conventional antibiotics along with phages will also be another area of research interest. These research outcomes can potentially identify strategies for the development of targeted therapies aimed at effective control of MDR bacterial infections.
