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Dr. Moumita Gangopadhyay

Assistant Professor (Sr. Gr.), Department of Chemistry, School of Physical Sciences, Amrita Vishwa Vidyapeetham, Amritapuri

Qualification: Ph.D
moumita@am.amrita.edu

Bio Publications Research Collaborations Achievements Presentations
Bio

Dr. Moumita Gangopadhyay received her Ph.D. in 2017 from Indian Institute of Technology Kharagpur, West Bengal, India. During her Ph.D., she worked in the field of organic photochemistry under the supervision of Prof. N D Pradeep Singh. Her thesis was titled “Target Specific Photodynamic Therapy (PDT) for Mono and Bimodal Anticancer Treatment”. She has also worked with Dr. Cornelia Bohne, Professor, University of Victoria, Canada. Later, she joined Ghatal Rabindra Satabarsiki Mahavidyalaya (a government-aided college) in Paschim Midnapore, West Bengal, as an Assistant Professor (Levels 10 and 11, Full Time) in June 2017. There she got the opportunity to initiate her teaching career. After working there for five successful years, she joined the Department of Chemistry, School of Physical Sciences, Amrita Vishwa Vidyapeetham in September 2022. To date, she has published 14 papers in international peer-reviewed journals and one book chapter; she has also attended more than 12 national and international conferences. She was also a recipient of SERB International Research Experience award from the Department of Science and Technology, Govt. Of India in 2022. Her present research interest is focused on the development of new fluorescent probes for in situ generation of oxygen, efficient gas therapy, and PDT in hypoxic tumor cells with live cell imaging.

Publications

Journal Article

Year : 2023

Comprehensive review of Pluronic® polymers of different shapes with prominent applications in photodynamic therapy

Cite this Research Publication : Saran S. Kumar, K.K. Harikrishnan, S.P. Urmila, V. Gauri, Appukuttan Saritha, Moumita Gangopadhyay*, Comprehensive review of Pluronic® polymers of different shapes with prominent applications in photodynamic therapy, European Polymer Journal, 2023, 200, 112534.

Publisher : Elsevier

Year : 2019

One- and Two-Photon-Activated Cysteine Persulfide Donors for Biological Targeting

Cite this Research Publication : Amrita Chaudhuri, Yarra Venkatesh, Joyjyoti Das, Moumita Gangopadhyay, Tapas K. Maiti and N. D. Pradeep Singh. One- and Two-Photon Activated Cysteine Persulfide Donors for Biological Targeting. J. Org. Chem. 2019, 84(18), 11441-11449. [DoI: 10.1021/acs.joc.9b01224]

Publisher : ACS Publications

Year : 2018

NIR fluorescent organic nanoparticles for photoinduced nitric oxide delivery with self monitoring and real time reporting abilities†

Cite this Research Publication : Krishna Kalyani Behara, Y Rajesh, Amrita Chaudhuri, Moumita Gangopadhyay, Mahitosh Mandal, N. D. Pradeep Singh. NIR fluorescent organic nanoparticles for photoinduced nitric oxide delivery with self-monitoring and real time reporting ability. J. Mater. Chem. B 2018, 6(38), 6042- 6046. [DoI: 10.1039/c8tb01209a]

Year : 2017

Smart and Reusable Biopolymer Nanocomposite for Simultaneous Microalgal Biomass Harvesting and Disruption: Integrated Downstream Processing for a Sustainable Biorefinery

Cite this Research Publication : Ramalingam Dineshkumar, Amrita Paul, Moumita Gangopadhyay, N. D. Pradeep Singh, Ramkrishna Sen. Smart and Reusable Biopolymer Nanocomposite for Simultaneous Microalgal Biomass Harvesting and Disruption: An Integrated Downstream Processing for Sustainable Biorefinery. ACS Sustainable Chemistry & Engineering, 2017, 5(1), 852-861. [DoI: 10.1021/acssuschemeng.6b02189]

Publisher : ACS Publications

Year : 2017

Single component image guided ‘On-demand’ drug delivery system for early stage prostate cancer

Cite this Research Publication : Sandipan Biswas, Joyjyoti Das, Shrabani Barman, Sk. Sheriff Shah, Moumita Gangopadhyay, Tapas K. Maity, N. D. Pradeep Singh. Single Component Image Guided 'On-demand' Drug Delivery System for Early Stage Prostate Cancer. Sensors & Actuators: B. Chemical 2017, 244, 327-333. [DoI: 10.1016/j.snb.2017.01.008]

Publisher : Elsevier

Year : 2017

Redox-responsive xanthene–coumarin–chlorambucil-based FRET-guided theranostics for “activatable” combination therapy with real-time monitoring†

Cite this Research Publication : Moumita Gangopadhyay, Rakesh Mengji, Amrita Paul, Yarra Venkatesh, Venugopal Vangala, Dr. Avijit Jana, Dr. N D Pradeep Singh. Redox-responsive Xanthene-Coumarin-Chlorambucil- based FRET-guided Theranostics for “Activatable” Combination Therapy with Real-Time Monitoring. Chem. Commun. 2017, 53(65), 9109-9112. [DoI: 10.1039/c7cc03241b]

Year : 2016

A p-Hydroxyphenacyl–Benzothiazole–Chlorambucil Conjugate as a Real-Time-Monitoring Drug-Delivery System Assisted by Excited-State Intramolecular Proton Transfer

Cite this Research Publication : Shrabani Barman, Sourav K. Mukhopadhyay, Sandipan Biswas, Surajit Nandi, Moumita Gangopadhyay, Satyahari Dey, Anakuthil Anoop, N. D. Pradeep Singh. A p-Hydroxyphenacyl– Benzothiazole–Chlorambucil Conjugate as a Real-Time-Monitoring Drug-Delivery System Assisted by Excited-State Intramolecular Proton Transfer. Angew. Chem. Int. Ed. 2016, 55(13), 4194–4198. [DoI: 10.1002/anie.201508901]

Publisher : Wiley

Year : 2016

Simple and efficient coumarin-based colorimetric and fluorescent chemosensor for F− detection: An ON1–OFF–ON2 fluorescent assay

Cite this Research Publication : Sandipan Biswas, Moumita Gangopadhyay, Shrabani Barman, Jit Sarkar, N. D. Pradeep Singh. Simple and efficient coumarin-based colorimetric and fluorescent chemosensor for F- detection: An ON1-OFF-ON2 fluorescent assay. Sensors and Actuators B: Chemical 2016, 222, 823-828. [DoI: 10.1016/j.snb.2015.08.090]

Publisher : Elsevier

Year : 2016

Fluorene–morpholine-based organic nanoparticles: lysosome-targeted pH-triggered two-photon photodynamic therapy with fluorescence switch on–off†

Cite this Research Publication : Moumita Gangopadhyay, Sourav K. Mukhopadhyay, Sree Gayathri, Sandipan Biswas, Shrabani Barman, Satyahari Dey, N D Pradeep Singh. Fluorene–Morpholine-based Organic Nanoparticles: Lysosome-targeted pH-triggered Two-photon Photodynamic Therapy with Fluorescence Switch On-Off. J. Mater. Chem. B 2016, 4(10), 1862-1868. [DoI: 10.1039/C5tb02563j]

Year : 2016

Organic Nanoparticle-Based Fluorescent Chemosensor for Selective Switching ON and OFF of Photodynamic Therapy (PDT)

Cite this Research Publication : Moumita Gangopadhyay, Dr. Avijit Jana, Y. Rajesh, Manoranjan Bera, Sandipan Biswas, Dr. Nilanjana Chowdhury, Dr. Yanli Zhao, Dr. Mahitosh Mandal, N D Pradeep Singh. Organic Nanoparticle-Based Fluorescent Chemosensor for Selective Switching ON and OFF of Photodynamic Therapy (PDT). ChemistrySelect 2016, 1(20), 6523-6531. [DoI: 10.1002/slct.201601380]

Year : 2015

Coumarin–benzothiazole–chlorambucil (Cou–Benz–Cbl) conjugate: an ESIPT based pH sensitive photoresponsive drug delivery system

Cite this Research Publication : Shrabani Barman, Sourav K. Mukhopadhyay, Moumita Gangopadhyay, Sandipan Biswas, Satyahari Dey, N. D. Pradeep Singh. Coumarin–benzothiazole–chlorambucil (Cou–Benz–Cbl) conjugate: an ESIPT based pH sensitive photoresponsive drug delivery system. J. Mater. Chem. B 2015, 3(17), 3490-3497. [DoI: 10.1039/c4tb02081b]

Year : 2015

A targeted, image-guided and dually locked photoresponsive drug delivery system

Cite this Research Publication : S. Karthik, B. N. Prashanth Kumar, Moumita Gangopadhyay, Mandal Mahitosh, N.D. Pradeep Singh. Targeted, Image Guided & Dually Locked Photoresponsive Drug Delivery System. J. Mater. Chem. B 2015, 3(5), 728-732. [DoI: 10.1039/c4tb01583e]

Year : 2015

Targeted photoresponsive TiO2–coumarin nanoconjugate for efficient combination therapy in MDA-MB-231 breast cancer cells: synergic effect of photodynamic therapy (PDT) and anticancer drug chlorambucil

Cite this Research Publication : Moumita Gangopadhyay, Sourav K. Mukhopadhyay, S. Karthik, Sharabani Barman, N. D. Pradeep Singh. Targeted Photoresponsive TiO2-Coumarin nanoconjugate for efficient Combination therapy in MDA-MB-231 breast cancer cells: Synergic effect of Photodynamic Therapy (PDT) and Anticancer drug Chlorambucil. Med. Chem. Commun. 2015, 6(5), 769-777. [DoI: 10.1039/c4md00481g] [This work has been mentioned as one of the “most-read and cited articles published in the journal” in 2015]

Year : 2015

Coumarin-containing-star-shaped 4-armpolyethylene glycol: targeted fluorescent organic nanoparticles for dual treatment of photodynamic therapy and chemotherapy

Cite this Research Publication : Moumita Gangopadhyay, Tanya Singh, Krishna Kalyani Behara, Surendra Karwa, S. K. Ghosh, N D Pradeep Singh. Coumarin Containing Star Shaped 4-arm Polyethylene glycol (PEG): Targeted Fluorescent Organic Nanoparticles for efficient Synergic treatment of Photodynamic therapy (PDT) and Chemotherapy. Photochemistry Photobiological Sciences 2015, 14(7), 1329-1336. [DoI: 10.1039/c5pp00057b]

Publisher : Springer

Year : 2014

Synthesis, photochemistry, DNA cleavage/binding and cytotoxic properties of fluorescent quinoxaline and quinoline hydroperoxides

Cite this Research Publication : Nilanjana Chowdhury, Moumita Gangopadhyay, S. Karthik, Mithu Baidya, S.K. Ghosh, N.D. Pradeep Singh. Synthesis, photochemistry, DNA cleavage/binding and cytotoxic properties of fluorescent quinoxaline and quinoline hydroperoxides. Journal of Photochemistry and Photobiology B: Biology 2014, 130, 188-198. [DoI: 10.1016/j.jphotobiol.2013.11.010]

Publisher : Elsevier

Book Chapter

Year : 2022

Antimicrobial photodynamic Therapy: A Promising Alternative for COVID-19 Treatment

Cite this Research Publication : Moumita Gangopadhyay, Antimicrobial photodynamic Therapy: A Promising Alternative for COVID-19 Treatment , New Horizon: Volume I Multidisciplinary Approaches to Current Science Issues ,Techno World (ISBN: 978-93-92145-29-2), May, 2022

Publisher : Techno World

Research

Research Areas

  • Development of stimuli-responsive organic nanoparticles for Photodynamic Therapy (PDT)
  • Development of stimuli-responsive nanoparticles for light-induced combination therapy against cancer
  • Development of target-specific fluorescent probes for sensing-induced cancer treatment with self-surveillance mechanism

Ongoing Research projects

  • Synergic treatment of gas therapy and PDT for hypoxic tumour cells:
  • In situ generation of molecular oxygen and concurrent PDT activity

Research Guidance

Nature of Degree Name of Degree Class Status Number
Regular/Full Time Ph.D. — Ongoing 2
Regular/Full Time Integrated M.Sc. (PG) Semester 8 Ongoing 2
Regular/Full Time Integrated M.Sc. (UG) Semester 6 Ongoing 3

Details of Research/Consultancy Project

Title of the Project Name of Funding Agency Duration Amount Status
Development of NIR fluorescent probes for dual action of volatile organic compound (VOC) detection and simultaneous PDT activity for anticancer treatment Science and Engineering Research Board, Govt. of India 2 years Rs. 25,00,000 Ongoing

Student Guidance

  • Mr. Vineeth M Pillai, M.Sc., Vineeth is presently working in the field of development of MnO2 nanosheets for in situ generation of O2 and concurrent PDT in hypoxic tumor cells.
  • Ms. M M Sreejaya, M.Sc, Sreejaya is presently working in the field of development of viscosity-responsive fluorescent probes for anticancer applications.
Collaborations
  1. Prof. N D Pradeep Singh, Indian Institute of Technology Kharagpur, West Bengal, India
  2. Dr. Kaushtabh Kumar Maiti, Senior Principal Scientist , CSIR-NIIST, Trivandrum, Kerala
  3. Prof. Shachar Richter, Material Science and Engineering, Tel Aviv University, Israel
  4. Dr. Avijit Jana, Senior Scientist, Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
Achievements
  • Received “Start-up Research Grant (SRG)” from Science and Engineering Research Board (SERB), Government of India [file no SRG/2023/001109] in September 223 titled ” Development of NIR fluorescent probes for dual action of volatile organic compound (VOC) detection and simultaneous PDT activity for anticancer treatment ” for a period of two years.
  • Received “SERB International Research Experience (SIRE)” grant from Science and Engineering Research Board (SERB), Government of India [Award Number: SIR/2022/000724] on May 12, 2022.
  • Received the S. Bhatnagar Young Scientist Award for the presentation (Oral) entitled “Nanorings in Photodynamic Therapy” in the International Seminar on Recent Advances in Chemistry & Material Sciences 2020 organised by the Indian Chemical Society.
  • Received best poster award on the topic of “Fluorene–Morpholine-based Organic Nanoparticles: Lysosome-targeted pH-triggered Two-photon Photodynamic Therapy with Fluorescence Switch On-Off” in the International conference “ 8 th Asian Photochemistry Conference (APC- 2014)”, held in IISER Trivandram during 9-13 th November 2014.
  • General Aptitude Test in Engineering (GATE, 2011).
  • CSIR-UGC National Eligibility Test (NET) (JUNE, 2011).
  • 1 st rank in B.Sc. (HONS) Examination, 2009 in Scottish Church College, University of Calcutta.
Presentations
  1. Delivered oral presentation on “ Fries Rearrangement & its Applications ” in 2009 in University of Calcutta.
  2. Delivered an Oral presentation on the topic of “ Targeted Photoresponsive TiO 2 -Coumarin nanoconjugate for efficient Combination therapy in MDA-MB-231 breast cancer cells: Synergic effect of PDT and Anticancer drug Chlorambucil ” at RDCST-2014 organized by NIT, Rourkela.
  3. Received best poster award on the topic of “Fluorene–Morpholine-based Organic Nanoparticles: Lysosome-targeted pH-triggered Two-photon Photodynamic Therapy with Fluorescence Switch On-Off” in the International conference “ 8 th Asian Photochemistry Conference (APC- 2014)”, held in IISER Trivandram during 9-13 th November 2014.
  4. Delivered an Oral presentation on the topic of “Anthracene-N-phenylethylenediamine derived organic nanoparticles: selective ratiometric fluorescent chemosensor for copper (II) and regulated switching ON and OFF of photodynamic therapy (PDT)” at 252nd American Chemical Society National Meeting in Philadelphia, PA, USA during August 21-25, 2016.
  5. Presented a paper entitled “ Coumarin-containing-star-shaped 4-arm polyethyleneglycol: targeted fluorescent organic nanoparticles for dual treatment of photodynamic therapy and chemotherapy” at One-Day State Level Seminar on “Recent Trends in Chemistry” March 23rd, 2019 (Saturday) organized by Department of Chemistry , Belda College.
  6. Presented poster on “ Redox-responsive Xanthene-Coumarin-Chlorambucil-based FRET-guided Theranostics for “Activatable” Combination with Real-Time Monitoring ” at “International Conference on Chemistry for Human Development (ICCHD-2020)” organized by Professor Asima Chatterjee Foundation with University of Calcutta and Heritage Institute of Technology during 9–11th January 2020.
  7. Presented a paper titled “ TiO 2 -coumarin nanoconjugate for efficient combination therapy in MDA-MB-231 breast cancer cells: synergic effect of photodynamic therapy (PDT) and anticancer drug chlorambucil ” in the two-day International Webinar on “Chemistry & Biology: Sustainable Progress of Human Civilization” organized by Dept. of Chemistry, P K College, Contai in collaboration with Indian Chemical Society on June 29-30 th 2020.
  8. Delivered an oral presentation on the topic of “Evolution of Cancer Treatment” at the International Webinar on “History of Science” organized by Department of Chemistry, Shri Shikshayatan College and Institute of Science, Education and Culture (ISEC) in collaboration with Indian Chemical Society on 28 th July, 2020 and published in the abstract book having serial no. 37.
  9. Presented a paper titled “Indian Women Scientists on the Frontline of the Fight against the COVID-19 Pandemic ” in the two-day International Webinar on “Contribution of Indian Women to Science” organized by Science Forum, Prabhat Kumar College, Contai in collaboration with Indian Science Congress Association, Kolkata & IQAC, Prabhat Kumar College, Contai on August 13-14 th 2020.
  10. Received the S. S. Bhatnagar Young Scientist Award for the presentation (Oral) entitled “Nanorings in Photodynamic Therapy” in the International Seminar on Recent Advances in Chemistry & Material Sciences 2020 organised by the Indian Chemical Society to commemorate the 159th Birth Anniversary of Acharya Prafulla Chandra Ray during the month long program on August, 2020. The abstract of the Oral Presentation is published in the Abstract Book (Page 81).
  11. Delivered an Oral presentation on the topic of “Endogenous Stimuli-Responsive theranostics for “activatable” image-guided combination therapy” in the Organic & Biochemistry Section of the 57th Annual Convention of Chemists, 2020 & International Conference on “Recent Trends in Chemical Sciences (RTCS-2020)” organized by the Indian Chemical Society, Kolkata during December 26 – 29, 2020. The Abstract of the Presentation is published in the Abstract Book (Page 266).
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