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Dr. Bindhu Paul

Associate Professor, Amrita School of Nanosciences and Molecular Medicine, Kochi

Qualification: Ph.D
bindhupaul@aims.amrita.edu
Dr. Bindhu Paul's Google Scholar Profile

Bio

Dr. Bindhu Paul joined Amrita Centre for Nanosciences and Molecular Medicine as Assistant Professor in January, 2011 and currently heads the laboratory of reproductive and developmental biology. She took M.Sc. in Zoology with specialization in Molecular Genetics and Cytogenetics from Banaras Hindu University, India, and Ph.D. in Population Genetics from Cochin University of Science and Technology, India. She pursued post-doctoral research in Japan at the National Institute for Basic Biology (National Institute of Natural Sciences). She spent 8 years in Japan doing research in the area of reproductive physiology/endocrinology/developmental biology. She has over 18 international publications to her credit. Her research focused on vertebrate sex determination and differentiation and how exposure to endocrine disruptors/synthetic hormones during early development influenced gonadal morphogenesis in Japanese medaka, which is widely used as a model organism for biomedical research. At Amrita, Dr. Bindhu Paul is investigating the interactions between engineered nanoparticles and germ cells, which are responsible for the transmission of genetic material between generations. Other major thrust areas of her research includes transgenerational toxicity potential of engineered nanoparticles, developmental origin of adulthood diseases and germline stem cell biology. A well-established fish facility holding natural as well as transgenic and mutant strains of Japanese Medaka is being maintained at Amrita by Dr. Bindhu’s team.

 

Publications

Journal Article

Year : 2021

Sex determination, gonadal sex differentiation, and plasticity in vertebrate species.

Cite this Research Publication : Yoshitaka Nagahama, Tapas Chakraborty, Dr. Bindhu Paul, Kohei Ohta, and Masaru Nakamura, “Sex determination, gonadal sex differentiation, and plasticity in vertebrate species.”, Physiological Reviews, vol. 101, no. 3, pp. 1237-1308, 2021.

Publisher : Physiological Reviews,

Year : 2020

Antioxidant and vasorelaxant effects of aqueous extract of large cardamom in L-NAME induced hypertensive rats

Cite this Research Publication : S.K. Kanthlal, Jipnomon Joseph, Paul, B., M, V., and Dr. Umadevi P., “Antioxidant and vasorelaxant effects of aqueous extract of large cardamom in L-NAME induced hypertensive rats”, Clinical and Experimental Hypertension, vol. 42, no. 7, pp. 581-589, 2020

Publisher : Clinical and Experimental Hypertension, Taylor & Francis,

Year : 2019

Graphene Quantum Dots Alter Proliferation and Meiosis of Germ Cells Only in Genetic Females of Japanese Medaka during Early Embryonic Development

Cite this Research Publication : K. S, Dr. Bindhu Paul, A, A., PD, A., S, S., and D, M., “Graphene Quantum Dots Alter Proliferation and Meiosis of Germ Cells Only in Genetic Females of Japanese Medaka during Early Embryonic Development”, ACS Applied Bio Materials , vol. 2, no. 2, pp. 737-746, 2019.

Publisher : ACS Applied Bio Materials

Year : 2017

Theranostic Iron Oxide/Gold Ion Nanoprobes for MR Imaging and Noninvasive RF Hyperthermia.

Cite this Research Publication : S. Fazal, Dr. Bindhu Paul, Shantikumar V Nair, and Dr. Deepthy Menon, “Theranostic Iron Oxide/Gold Ion Nanoprobes for MR Imaging and Noninvasive RF Hyperthermia.”, ACS Applied Materials and Interfaces, vol. 9, no. 34, pp. 28260-28272, 2017.

Publisher : ACS Applied Materials and Interfaces

Year : 2017

Mechanistic Understanding of Phenyllactic Acid Mediated Inhibition of Quorum Sensing and Biofilm Development in Pseudomonas Aeruginosa

Cite this Research Publication : M. Chatterjee, D'Morris, S., Paul, V., Warrier, S., Vasudevan, A. Kumar, Muralidharan Vanuopadath, Nair, S. Sadasivan, Dr. Bindhu Paul, Dr. Gopi Mohan C., and Dr. Raja Biswas, “Mechanistic Understanding of Phenyllactic Acid Mediated Inhibition of Quorum Sensing and Biofilm Development in Pseudomonas Aeruginosa”, Appl Microbiol Biotechnol, vol. 101, no. 22, pp. 8223-8236, 2017

Publisher : Appl Microbiol Biotechnol

Year : 2017

Effects of N-Nitrosodiethylamine, a Potent Carcinogen, on Sexual Development, Gametogenesis, and Oocyte Maturation

Cite this Research Publication : Dr. Bindhu Paul, Nair, R., Victor, A. C., and Paul-Prasanth, B., “Effects of N-Nitrosodiethylamine, a Potent Carcinogen, on Sexual Development, Gametogenesis, and Oocyte Maturation”, Sexual Development, vol. 11, no. 3, pp. 161-167, 2017.

Publisher : Sexual Development

Year : 2015

Sequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cells

Cite this Research Publication : S. Narayanan, Dr. Ullas Mony, Vijaykumar, D. K., Dr. Manzoor K., Dr. Bindhu Paul, and Dr. Deepthy Menon, “Sequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cells”, Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 11, pp. 1399-1406, 2015.

Publisher : Nanomedicine: Nanotechnology, Biology, and Medicine, Elsevier Inc.,

Year : 2014

Sexually dimorphic expression of the sex chromosome-linked genes cntfa and pdlim3a in the medaka brain

Cite this Research Publication : S. Maehiro, Takeuchi, A., Yamashita, J., Hiraki, T., Kawabata, Y., Nakasone, K., Hosono, K., Usami, T., Dr. Bindhu Paul, Yoshitaka Nagahama, Oka, Y., and Okubo, K., “Sexually dimorphic expression of the sex chromosome-linked genes cntfa and pdlim3a in the medaka brain”, Biochemical and Biophysical Research Communications, vol. 445, pp. 113 - 119, 2014.

Publisher : Biochemical and Biophysical Research Communications

Year : 2014

ERRATUM: Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists

Cite this Research Publication : Dr. Bindhu Paul, Bhandari, R. K., Kobayashi, T., Horiguchi, R., Kobayashi, Y., Nakamoto, M., Shibata, Y., Sakai, F., Nakamura, M., and Nagahama, Y., “Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists”, Scientific reports, vol. 3, p. 2862, 2013.

Publisher : Scientific reports, Nature Publishing Group.

Year : 2013

Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists

Cite this Research Publication : Dr. Bindhu Paul, Bhandari, R. K., Kobayashi, T., Horiguchi, R., Kobayashi, Y., Nakamoto, M., Shibata, Y., Sakai, F., Nakamura, M., and Nagahama, Y., “Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists”, Scientific reports, vol. 3, p. 2862, 2013.

Publisher : Scientific reports, Nature Publishing Group,

Year : 2013

Poly (lactic acid)–chitosan–collagen composite nanofibers as substrates for blood outgrowth endothelial cells

Cite this Research Publication : B. Swarnalatha, Nair, S. L., Shalumon, K. T., Milbauer, L. C., Dr. Jayakumar Rangasamy, Dr. Bindhu Paul, Menon, K. K., Hebbel, R. P., Somani, A., and Shantikumar V. Nair, “Poly (lactic acid)–chitosan–collagen composite nanofibers as substrates for blood outgrowth endothelial cells”, International Journal of Biological Macromolecules, vol. 58, pp. 220 - 224, 2013.

Publisher : International Journal of Biological Macromolecules

Year : 2013

Ol4E-T, a Eukaryotic Translation Initiation Factor 4E-Binding Protein of Medaka Fish (Oryzias latipes), Can Interact With Nanos3 and Vasa In Vitro

Cite this Research Publication : H. Zhao, Guan, G., Duan, J., Cheng, N., Wang, J., Matsuda, M., Dr. Bindhu Paul, and Nagahama, Y., “Ol4E-T, a Eukaryotic Translation Initiation Factor 4E-Binding Protein of Medaka Fish (Oryzias latipes), Can Interact With Nanos3 and Vasa In Vitro”, Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, vol. 320, pp. 10–21, 2013.

Publisher : Journal of Experimental Zoology Part B: Molecular and Developmental Evolution

Year : 2011

Analysis of sexually dimorphic expression of genes at early gonadogenesis of pejerrey Odontesthes bonariensis using a heterologous microarray

Cite this Research Publication : J. I. Fernandino, Popesku, J. T., Dr. Bindhu Paul, Xiong, H., Hattori, R. S., Oura, M., Strüssmann, C. A., Somoza, G. M., Matsuda, M., Nagahama, Y., and , “Analysis of sexually dimorphic expression of genes at early gonadogenesis of pejerrey Odontesthes bonariensis using a heterologous microarray”, Sexual development, vol. 5, pp. 89–101, 2011.

Publisher : Karger Publishers

Year : 2011

Sex differences in aromatase gene expression in the medaka brain

Cite this Research Publication : K. Okubo, Takeuchi, A., Chaube, R., Dr. Bindhu Paul, Kanda, S., Oka, Y., and Nagahama, Y., “Sex differences in aromatase gene expression in the medaka brain”, Journal of neuroendocrinology, vol. 23, pp. 412–423, 2011.

Publisher : Wiley Online Library

Year : 2011

Exposure to diethylstilbestrol during embryonic and larval stages of medaka fish (Oryzias latipes) leads to sex reversal in genetic males and reduced gonad weight in genetic females

Cite this Research Publication : Dr. Bindhu Paul, Shibata, Y., Horiguchi, R., and Nagahama, Y., “Exposure to diethylstilbestrol during embryonic and larval stages of medaka fish (Oryzias latipes) leads to sex reversal in genetic males and reduced gonad weight in genetic females”, Endocrinology, vol. 152, pp. 707–717, 2011.

Publisher : Endocrinology, Endocrine Society Chevy Chase, MD,

Year : 2011

Sex determination in fishes

Cite this Research Publication : Dr. Bindhu Paul, Nakamura, M., and Nagahama, Y., “Sex determination in fishes”, Hormones and reproduction of vertebrates: fishes, vol. 1, pp. 1–14, 2011.

Publisher : Hormones and reproduction of vertebrates: fishes

Year : 2011

Sexual Behavior in Teleosts: Role of Gonadal Hormones

Cite this Research Publication : Dr. Bindhu Paul and Nagahama, Y., “Sexual Behavior in Teleosts: Role of Gonadal Hormones”, Indian Journal of Science and Technology, vol. 4, pp. 14–14, 2011.

Publisher : Indian Journal of Science and Technology

Year : 2010

Expression of gonadal soma derived factor (GSDF) is spatially and temporally correlated with early testicular differentiation in medaka

Cite this Research Publication : Y. Shibata, Dr. Bindhu Paul, Suzuki, A., Usami, T., Nakamoto, M., Matsuda, M., and Nagahama, Y., “Expression of gonadal soma derived factor (GSDF) is spatially and temporally correlated with early testicular differentiation in medaka”, Gene Expression Patterns, vol. 10, pp. 283–289, 2010.

Publisher : Gene Expression Patterns, Elsevier,

Year : 2009

A relaxin-like peptide purified from radial nerves induces oocyte maturation and ovulation in the starfish, Asterina pectinifera

Cite this Research Publication : M. Mita, Yoshikuni, M., Ohno, K., Shibata, Y., Dr. Bindhu Paul, Pitchayawasin, S., Isobe, M., and Nagahama, Y., “A relaxin-like peptide purified from radial nerves induces oocyte maturation and ovulation in the starfish, Asterina pectinifera”, Proceedings of the National Academy of Sciences, vol. 106, pp. 9507–9512, 2009.

Publisher : Proceedings of the National Academy of Sciences, National Acad Sciences,

Year : 2009

Sex change in the Gobiid fish is mediated through rapid switching of gonadotropin receptors from ovarian to testicular portion or vice versa

Cite this Research Publication : Y. Kobayashi, Nakamura, M., Sunobe, T., Usami, T., Kobayashi, T., Manabe, H., Dr. Bindhu Paul, Suzuki, N., and Nagahama, Y., “Sex change in the Gobiid fish is mediated through rapid switching of gonadotropin receptors from ovarian to testicular portion or vice versa”, Endocrinology, vol. 150, pp. 1503–1511, 2009.

Publisher : Endocrinology

Year : 2008

Functional analysis of the medaka sex determining gene, DMY-A minireview

Cite this Research Publication : Dr. Bindhu Paul, Matsuda, M., Kobayashi, T., Suzuki, A., and Nagahama, Y., “Functional analysis of the medaka sex determining gene, DMY-A minireview”, CYBIUM, vol. 32, pp. 72–73, 2008.

Publisher : CYBIUM, SOC FRANCAISE D ICHTYOLOGIE MUSEUM NATL D HISTOIRE NATURELLE, 43 RUE CUVIER, 75231 PARIS, FRANCE,

Year : 2008

Sexual dimorphic expression of genes in gonads during early differentiation of a teleost fish, the Nile tilapia Oreochromis niloticus

Cite this Research Publication : S. Ijiri, Kaneko, H., Kobayashi, T., Wang, D. - S., Sakai, F., Dr. Bindhu Paul, Nakamura, M., and Nagahama, Y., “Sexual dimorphic expression of genes in gonads during early differentiation of a teleost fish, the Nile tilapia Oreochromis niloticus”, Biology of reproduction, vol. 78, pp. 333–341, 2008.

Publisher : Biology of reproduction, Society for the Study of Reproduction,

Year : 2007

A novel type of P450c17 lacking the lyase activity is responsible for C21-steroid biosynthesis in the fish ovary and head kidney

Cite this Research Publication : L. - Y. Zhou, Wang, D. - S., Kobayashi, T., Yano, A., Dr. Bindhu Paul, Suzuki, A., Sakai, F., and Nagahama, Y., “A novel type of P450c17 lacking the lyase activity is responsible for C21-steroid biosynthesis in the fish ovary and head kidney”, Endocrinology, vol. 148, pp. 4282–4291, 2007.

Publisher : Endocrinology, Endocrine Society,

Year : 2007

Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein/steroidogenic factor 1

Cite this Research Publication : D. - S. Wang, Kobayashi, T., Zhou, L. - Y., Dr. Bindhu Paul, Ijiri, S., Sakai, F., Okubo, K., Morohashi, K. -ichirou, and Nagahama, Y., “Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein/steroidogenic factor 1”, Molecular Endocrinology, vol. 21, pp. 712–725, 2007.

Publisher : Molecular Endocrinology, Endocrine Society,

Year : 2007

DMY gene induces male development in genetically female (XX) medaka fish

Cite this Research Publication : M. Matsuda, Shinomiya, A., Kinoshita, M., Suzuki, A., Kobayashi, T., Dr. Bindhu Paul, Lau, E. -lieng, Hamaguchi, S., Sakaizumi, M., and Nagahama, Y., “DMY gene induces male development in genetically female (XX) medaka fish”, Proceedings of the National Academy of Sciences, vol. 104, pp. 3865–3870, 2007.

Publisher : Proceedings of the National Academy of Sciences

Year : 2007

Characterization, expression and transcriptional regulation of P450c17-I and-II in the medaka, Oryzias latipes

Cite this Research Publication : L. - Y. Zhou, Wang, D. - S., Shibata, Y., Dr. Bindhu Paul, Suzuki, A., and Nagahama, Y., “Characterization, expression and transcriptional regulation of P450c17-I and-II in the medaka, Oryzias latipes”, Biochemical and biophysical research communications, vol. 362, pp. 619–625, 2007.

Publisher : Biochemical and biophysical research communications, Academic Press,

Year : 2006

Knock-down of DMY initiates female pathway in the genetic male medaka, Oryzias latipes

Cite this Research Publication : Dr. Bindhu Paul, Matsuda, M., Lau, E. -lieng, Suzuki, A., Sakai, F., Kobayashi, T., and Nagahama, Y., “Knock-down of DMY initiates female pathway in the genetic male medaka, Oryzias latipes”, Biochemical and biophysical research communications, vol. 351, pp. 815–819, 2006.

Publisher : Biochemical and biophysical research communications, Academic Press.

Research

Role of Engineered Nanoparticles on Reproductive and Developmental Toxicity: A Multi-generational Approach

The project intends to critically analyze the potential of engineered nanoparticles, both organic (Graphene oxide) and inorganic (Zinc oxide), to induce anomalies in the reproduction and development of Japanese medaka as well as their ability to exert damaging effects on the germ line through mitotically stable epigenetic modifications that could result in transgenerational toxicities.

Development of Pluripotent Stem Cells from Human Ovarian Germ Line Stem Cells and Their Differentiation into Adipocytes

The centre of interest of this project is to isolate ovarian germ line stem cells (OGSCs) and examine whether these cells could be induced to generate pluripotent stem cells, which in turn could be differentiated into other lineages using biomimetic scaffolds such as hydrogels (3D environment) for regenerative engineering applications.

Development of New Assay for the Evaluation of Pesticides used in India for Endocrine Disruption using Japanese Medaka (Orzyias Latipes)

The project focuses on developing an assay for the detection of different endocrine disruptors which are constantly getting introduced into our premises. Specifically, we aim to develop an assay that can confirm the endocrine disrupting potential of a substance within a short span of time using Japanese medaka embryos and adults as the model organisms.

 

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