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Dr. Annamma Mathai

Research Scientist, School of Medicine, Kochi

Qualification: MSc, Ph.D
@amrita.edu

Bio

Dr. Annamma Mathai is a trained immunopathologist from Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh. She has worked as a scientist in Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram for more than three and a half decades, on immunopatholgy and diagnostic immunology of neurotuberculosis as well as autoimmune neurological disorders.

Publications

Journal Article

Year : 2016

Autoimmune atypical parkinsonism – A group of treatable parkinsonism

Cite this Research Publication : Sudheeran Kannoth, Anandkumar Anandakuttan, Annamma Mathai, Anuja Nirmala Sasikumar & Vivek Nambiar. Autoimmune atypical parkinsonism -A group of treatable parkinsonism. Journal of Neurological Sciences;2016 362:40-46

Year : 2015

Autoimmune encephalitis: Clinical diagnosis versus antibody confirmation

Cite this Research Publication : Asha Caroline Cyril, Sruthi S. Nair, Annamma Mathai, Sudheeran Kannoth &Sanjeev V Thomas, Autoimmune encephalitis:Clinical diagnosis versus antibody confirmation. .Annals of Indian Academy of Neurology, 2015, 18(4) 408-411

Year : 2013

Women with epilepsy and infertility have different reproductive hormone profile than others

Cite this Research Publication : Sanjeev V Thomas, P S. Sarma, C. Nirmala, Annamma Mathai, Sara E Thomas, & Asha C Thomas. Women with epilepsy and infertility have different reproductive hormone profile than others. Annals of Indian Academy of Neurology, 2013;16(4):544-548

Year : 2012

Trehalose 6, 6’ dimycolate (cord factor) induced pulmonary granuloma in naive and lymphopenic mice

Cite this Research Publication : Annamma M, Neelima R, Harikrishnan V.S, Radhakrishnan VV. Trehalose 6,6’ dimycolate (cord factor) induced pulmonary granuloma in naïve and lymphopenic mice. J Infect Dis Immun: 2012; 4 (3):29-35.

Year : 2011

Utility of cord factor antigen of Mycobacterium tuberculosis for the laboratory diagnosis of tuberculous meningitis

Cite this Research Publication : Annmma M, Neelima R, Nair MD, Radhakrishnan VV. Utility of cord factor antigen of Mycobacterium tuberculosis for the laboratory diagnosis of tuberculous meningitis. Int Res J Microbiol 2011, 2:167-172

Year : 2011

An immuno assay using cord factor for the confirmatory diagnosis of intracranial tuberculoma

Cite this Research Publication : Annamma M, Neelima R, Harikrishna V.S, Radhakrishnan VV. An immuno assay using cord factor for the confirmatory diagnosis of intracranial tuberculoma. J. Infect DIS Immun: 2011:3:64-67.

Year : 2009

Assessment of four recombinant mycobacterial antigens as serodiagnostic markers for pulmonary tuberculosis

Cite this Research Publication : Sumi S, Madhavilathe GK, Sathish M, Annmma M, Radhakrishnan VV. Assessment of four recombinant mycobacterial antigens as serodiagnostic markers of pulmonary tuberculosis. J Clin Med Res 2009; 1 (3) 35-40

Year : 2004

Serum tumour necrosis factor-α and soluble tumour necrosis factor receptors levels in patients with Guillain–Barre syndrome

Cite this Research Publication : Radhakrishnan V.V, Sumi MG, Reuben S, Annamma M, Nair MD: Serum tumor necrosis factor-alpha and soluble tumor necrosis factor receptors levels in patients with Guillain-Barre syndrome. Acta Neurologica Scand. 2004;109(1):71-74

Year : 2003

Detection of heat stable mycobacterial antigen in cerebrospinal fluid by Dot – Immunobinding assay

Cite this Research Publication : Annamma M, Radhakrishnan V.V., Sarada C, George S.M: Detection of heat stable mycobacterial antigen in cerebrospinal fluid by Dot – Immunobinding assay. Neurol India 2003;51:52-54.

Year : 2003

Intravenous immunoglobulin reduces Tumour Necrosis Factor alpha in patients with Guillain Barre syndrome

Cite this Research Publication : Reuben S, Sumi MG, Annamma M, Nair MD, Radhakrishnan V.V.: Intravenous immunoglobulin reduces Tumour Necrosis Factor alpha in patients with Guillain Barre syndrome. Neurol India. 2003;51(4):487-489

Year : 2003

Circulating tumour necrosis factor alpha (TNF-µ) and soluble tumour Necrosis factor (TNF) receptors in patients with Guillain Barre Syndrome

Cite this Research Publication : Radhakrishnan V.V, Sumi MG, Reuben S, Annamma M, Nair MD: Circulating tumour necrosis factor alpha (TNF-µ) and soluble tumour Necrosis factor (TNF) receptors in patients with Guillain Barre Syndrome. Indian J. Medical Res. 2003;117:216-220

Year : 2002

Serum tumor necrosis factor – alpha in Guillain – Barre syndrome and its relation to plasma exchange

Cite this Research Publication : Reuben S, Annamma M, Sumi MG, Nair MD, Radhakrishnan V.V. Serum tumor necrosis factor – alpha in Guillain – Barre syndrome and its relation to plasma exchange. The Neurologist 2002;8:47-50.

Year : 2002

Immunocytochemical method for early laboratory diagnosis of Tuberculous meningitis

Cite this Research Publication : Sumi M.G, Annamma M, Reuben S, Sarada C, Radhakrishnan V.V. Immunocytochemical method for early laboratory diagnosis of Tuberculous meningitis. Clin Diag Lab Immunol 2002. 9:344-347

Year : 2002

A comparative evaluation of dot immunobinding assay and polymerase chain reaction for the laboratory diagnosis of tuberculous meningitis

Cite this Research Publication : Sumi MG, Annamma M, Reuben S, Sarada C, Radhakrishnan V.V, Indulakshmi R, Sathish M, Ajayakumar R, Manju Y.K. A comparative evaluation of dot immunobinding assay and polymerase chain reaction for the laboratory diagnosis of tuberculous meningitis. Diag. Microbiol Infect Dis 2002, 42:35-38

Year : 2001

Significance of serum antibody to GD1b ganglioside in patients with Gullain-Barre syndrome

Cite this Research Publication : Reuben S, Annamma M, Sumi MG, Nair MD, Radhakrishnan V.V. Significiance of serum antibody to GD1b ganglioside in patients with Gullain Barre syndrome. Indian J Med Res 2001; 113-234-238.

Year : 2001

Diagnostic techniques for the laboratory diagnosis of intracranial tuberculoma

Cite this Research Publication : Sumi MG, Annamma M, Sheela R, Radhakrishnan NS, Radhakrishnan V,V, Indulekshmy R, Mundayoor S. Diagnostic techniques for the laboratory diagnosis of intracranial tuberculoma. Clin Neuropathol 2001,20,176-180

Year : 2001

A newer approach for the laboratory diagnosis of tuberculous meningitis

Cite this Research Publication : Annamma M, Radhakrishnan V.V. Sumi MG, Sarada C. A newer approach for the laboratory diagnosis of tuberculous meningitis Diag Microbiol Infect Dis 2001;39:225-228.

Year : 2000

Significance of circulating immune complexes in Myasthenia gravis

Cite this Research Publication : Annamma M, Sarada C, Radhakrishnan V.V. Significance of circulating immune complexes in Myasthenia gravis. Indian J Med Res 2000;111:180-183

Year : 2000

Rapid diagnosis of Tuberculous meningitis by a dot – immunobinding assay

Cite this Research Publication : Sumi MG, Annamma M, Sarada C, Radhakrishnan V.V. Rapid diagnosis of Tuberculous meningitis by a dot – immunobinding assay. Acta Neurol Scand 2000, 101:61-64.

Year : 1999

Rapid diagnosis of Tuberculous Meningitis by a DOT immunobinding assay to detect Mycobacterial antigen in cerebrospinal fluid specimens

Cite this Research Publication : Sumi MG, Annamma M, Sarada C, Radhakrishnan V.V. Rapid diagnosis of Tuberculous Meningitis by a DOT immunobinding assay to detect Mycobacterial antigen in cerebrospinal fluid specimens. J Clin Microbiol 1999,37:3925-3927

Year : 1999

An enzyme linked immunosorbent assay for antibodies against acid soluble skeletal muscle antigen in Myasthenia gravis

Cite this Research Publication : Annamma M, Sarada C, Radhakrishnan V.V. An enzyme linked immunosorbent assay for antibodies against acid soluble skeletal muscle antigen in Myasthenia gravis. Acta Neurol Scand 1999;100:175-177

Year : 1995

Characterization of Mycobacterial antigens by ELISA and immunoblot methods

Cite this Research Publication : Annamma M, Radhakrishnan V.V. Characterization of Mycobacterial antigens by ELISA and immunoblot methods. India J Pathol Microbiol 1995;38:299-303.

Year : 1994

Diagnosis of tuberculous meningitis confirmed by means of an immunoblot method

Cite this Research Publication : Annamma M, Radhakrishnan VV, Sehgal S. Diagnosis of tuberculous meningitis confirmed by means of an immunoblot method. J. Infect 1994;29:33-39.

Year : 1993

Detection of IgG antibody to Mycobacterium tuberculosis antigen 5 by ELISA in sera of patients with Pulmonary tuberculosis

Cite this Research Publication : Sundaram P, Annamma M, Radhakrishnan V.V. Detection of IgG antibody to Mycobacterium tuberculosis antigen 5 by ELISA in sera of patients with Pulmonary tuberculosis. Indian J Allergy Appl Immunol 1993;7:29-33.

Year : 1993

Immune complex levels and plasmapheresis in Guillain Barre Syndrome

Cite this Research Publication : Tharakan JAK, Mathai J, Annamma M, Sulochana PV. Immune complex levels and plasmapheresis in Guillain Barre Syndrome. Acta Neurologica 1993;15:138-141

Year : 1993

Correlation between the isolation of Mycobacterium tuberculosis and estimation of mycobacterial antigen in cisternal, ventricular and lumbar cerebrospinal fluids of patients with tuberculous meningitis

Cite this Research Publication : Radhakrishnan V,V, Annamma M. Correlation between the isolation of mycobacterium tuberculosis and estimation of mycobacterial antigen in cisternal, ventricular and lumbar cerebrospinal fluids of patients with tuberculous meningitis. Indian Journal Pathol Microbiol 1993;36:341-347.

Year : 1992

Comparative evaluation of tuberculin purified protein derivative, commercial PPD and BCG in the laboratory diagnosis of tuberculous meningitis

Cite this Research Publication : Annamma M, Radhakrishnan V.V, Thomas M. Comparative evaluation of tuberculin purified protein derivative, commercial PPD and BCG in the laboratory diagnosis of tuberculous meningitis. J Assodc Phys India 1992;40:14-17.

Year : 1992

Significance of IgG antibody of mycobacterium tuberculosis antigen 5 in CSF of patients with chronic meningitis

Cite this Research Publication : Annamma M, Radhkrishnan V.V. Thomas M. Significance of IgG antibody of mycobacterium tuberculosis antigen 5 in CSF of patients with chronic meningitis. India J Med Microbiol 1992;10:94-100.

Year : 1992

Diagnostic significance of circulating immune complexes in patients with pulmonary tuberculosis

Cite this Research Publication : Radhakrishnan V.V, Annamma M, Sundaram P, Diagnostic significance of circulating immune complexes in patients with pulmonary tuberculosis J. Med Microbiol 1992;36:128-131.

Year : 1991

Correlation between culture of M. Tuberculosis and antimycobacterial antibody in lumbar, ventricular and cisternal cerebrospinal fluids of patients with tuberculous meningitis

Cite this Research Publication : Radhakrishnan V.V, Annamma M, Thomas M. Correlation between culture of M. Tuberculosis and antimycobacterial antibody in lumbar, ventricular and cisternal cerebrospinal fluids of patients with tuberculous meningitis. Indian J Exp Biol 1991;29:845-848.

Year : 1991

Enzyme linked immunosorbent assay to detect mycobacterium tubeculosis antigen 5 and antimycobacterial antibody in CSF of patients with tuberculous meningitis

Cite this Research Publication : Radhakrishnan V.V, Annamma M. Enzyme linked immunosorbent assay to detect mycobacterium tubeculosis antigen 5 and antimycobacterial antibody in CSF of patients with tuberculous meningitis. J Clin Lab Anal 1991;5:233-237.

Year : 1991

Immunohistochemical demonstration of mycobactrial antigens in intracranial tuberculoma

Cite this Research Publication : Radhakrishnan V.V, Annamma M, Radhakrishnan N.S. Rout D, Sehgal S. Immunohistochemical demonstration of mycobactrial antigens in intracranial tuberculoma. Indian J exp Biol 1991;29:641-644.

Year : 1991

Potential application of dot immunobinding assay as a rapid diagnostic test in tuberculous meningitis

Cite this Research Publication : Radhakrishnan V.V, Annamma M. Potential application of dot immunobinding assay as a rapid diagnostic test in tuberculous meningitis. Indian J Exp Biol 1991;29:437-440.

Year : 1991

A Dot-Immunobinding assay for the laboratory diagnosis of tuberculous meningitis and its comparison with ELISA

Cite this Research Publication : Radhakrishnan V.V, Annamma M. A Dot-Immunobinding assay for the laboratory diagnosis of tuberculous meningitis and its comparison with ELISA. J Appl Bacateriol 1991;71:428-433.

Year : 1991

Detection of mycobacterial antigen in cerebrospinal fluid by inhibition enzyme linked immunosorbent assay and its diagnostic application in Tuberculous meningitis

Cite this Research Publication : Annamma M. Radhakrishnan V.V. Detection of mycobacterial antigen in cerebrospinal fluid by inhibition enzyme linked immunosorbent assay and its diagnostic application in Tuberculous meningitis. Indian J Med Microbiol 1991;9:16-21.

Year : 1991

Humoral Immune reactions in tuberculous meningitis

Cite this Research Publication : Annamma M, Radhakrishanan V.V. Humoral Immune reactions in tuberculous meningitis. Indian J Med Sci 1991;45:233-238.

Year : 1991

Rapid serodiagnostic test for pulmonary tuberculosis

Cite this Research Publication : Radhakrishnan V.V, Annamma M. "Rapid serodiagnostic test for pulmonary tuberculosis." Indian J Exp. Biol 1991;29-448-451.

Year : 1991

Circulating immune complexes in CSF of patient with Tuberculous Meningitis

Cite this Research Publication : Annamma M, Radhakrishnan V.V. Circulating immune complexes in CSF of patient with Tuberculous Meningitis. Indian J Exp Biol 1991;29:973-976.

Year : 1991

Rapid diagnosis of tuberculous meningitis with a Dot enzyme immuno assay to detect antibody in cerebrospinal fluid

Cite this Research Publication : Annamma M, Radhakrishnan V.V, Thomas M. Rapid diagnosis of tuberculous meningitis with a Dot enzyme immuno assay to detect antibody in cerebrospinal fluid. European J Infect Dis and Clin Microbiol 1991;10:440-443.

Year : 1990

Diagnosis of tuberculous meningitis by an enzyme linked immunosorobent assay to detect mycobacterial antigen and antibody in cerebrospinal fluid

Cite this Research Publication : Annamma M Radhakrishnan V.V,Sehgal S. Diagnosis of tuberculous meningitis by an enzyme linked immunosorobent assay to detect mycobacterial antigen and antibody in cerebrospinal fluid. Med Microbiol Immunol 1990;179:281-288.

Year : 1990

Correlation between culture positivity for Mycobacterium tuberculosis and IgG antibody to Mycobacterium tuberculosis antigen 5 in CSF of patient with Tuberculous Meningitis

Cite this Research Publication : Radhakrishnan V.V, Annamma M, Mohan PK, Sehgal S. Correlation between culture positivity for Mycobacterium tuberculosis and IgG antibody to Mycobacterium tuberculosis antigen 5 in CSF of patient with Tuberculous Meningitis. Neurol India, 1990;38:537-544.

Year : 1990

Correlation between culture of mycobacterium tuberculosis and detection of mycobacterial antigen in cerebrospinal fluid of patients with tuberculous meningitis

Cite this Research Publication : Radhakrishnan V.V, Sehgal S, Annamma M. Correlation between culture of mycobacterium tuberculosis and detection of mycobacterial antigen in cerebrospinal fluid of patients with tuberculous meningitis. J Med Microbiol 1990;33:223-226.

Year : 1990

Immunoelectrophoresis of mycobacterial antigens

Cite this Research Publication : Radhakrishnan V.V, Annamma M, Rao SB, Sehgal S. Immunoelectrophoresis of mycobacterial antigens. Indian J Exp. Biol 1990;28:812-815.

Year : 1990

IgG antibody to Mycobacterium tuberculosis antigen 5 in cerebrospinal fluid and its diagnostic application in tuberculous meningitis

Cite this Research Publication : Annamma M, Radhakrishnan V.V, Sehgal S. IgG antibody to Mycobacterium tuberculosis antigen 5 in cerebrospinal fluid and its diagnostic application in tuberculous meningitis. Indian J exp. Biol 1990;28:816-820.

Year : 1990

ELISA of IgG antibody to mycobacterium tuberculous antigen 5, PPD in CSF in tuberculous meningitis patients

Cite this Research Publication : Annamma M, Radhakrishnan V.V, Mohan PK, Sehgal S. ELISA of IgG antibody to mycobacterium tuberculous antigen 5, PPD in CSF in tuberculous meningitis patients. Indian J Med Res 1990;91:425-430.

Year : 1990

Detection of mycobacterial antigen in cerebrospinal fluid; diagnostic and prognostic significance

Cite this Research Publication : Radhakrishnan V.V, Annamma M. Detection of mycobacterial antigen in cerebrospinal fluid; diagnostic and prognostic significance. J Neurol Science 1990;99:93-99.

Year : 1989

Enzyme linked immunosorbent assay for IgG antibody to tuberculin purified protein derivative in cerebrospinal fluid specimens of patients with tuberculous meningitis

Cite this Research Publication : Annamma M ,Radhakrishnan V.V, Sehgal S, Mohan P.K. Enzyme linked immunosorbent assay for IgG antibody to tuberculin purified protein derivative in cerebrospinal fluid specimens of patients with tuberculous meningitis. Indian J Med Microbiol 1989;7:98-104.

Year : 1986

Serum Immunoglobulin in patients with endomyocardial Fibrosis

Cite this Research Publication : Annamma M, Kartha CC, Balakrishan KG, Serum Immunoglobulin in patients with endomyocardial Fibrosis. Indian Heart J, 1986;38:470-472.

Year : 1984

Immunohistological studies in Endomyocardial Fibrosis

Cite this Research Publication : Kartha CC, Annamma M, Balakrishnan KG, Valiathan MS. Immunohistological studies in Endomyocardial Fibrosis. Indian Heart J 1984;36:90-91.

Year : 1983

Hyaluronidase and circulating Cryptococcal capsular polysaccharide titre

Cite this Research Publication : Radhakrishnan V.V, Annamma M. Hyaluronidase and circulating Cryptococcal capsular polysaccharide titre. Indian J Exp Biol 1983. 21:557-559.

Year : 1983

Role of hyaluronidase in invitro phagocytosis of encapsulated yeast of Cryptococcus neoformans

Cite this Research Publication : Radhakrishnan V.V, Annamma M. Role of hyaluronidase in invitro phagocytosis of encapsulated yeast of Cryptococcus neoformans. Indian J Exp Biol 1983;21:285-288.

Year : 1982

The role of hyaluronidase in experimental Cryptococcal infections

Cite this Research Publication : Radhakrishnan V.V, Annamma M, Shanmugham J, Mathew GJ. The role of hyaluronidase in experimental Cryptococcal infections. Surg Neurol 1982;17:239-244.

Prizes / Awards
  • NAMS Award 2001

    Recipient of “Sir Shriram Memorial” award for the best scientific publication for the year 2001 by the National Academy of Medical Sciences (NAMS) New Delhi.

  • ICMR award 1993

    Recipient of “Chaturvedi Ghanshyam Das Jaigopal award for the research conducted in the field of Central Nervous System Tuberculosis” given by Indian Council for Medical Research (ICMR), New Delhi in the year 1993.

  • Award of a book from PGIMER – 1981

    Recipient of the award of a book at the XI Annual convocation in recognition of performance during M.Sc. MLT degree course.

Chapters in Books
  • Sumi S, Annamma M, Radhakrishnan V.V. Chapter on Dot- Immunobinding Assay Methods in Molecular Biology: Edited by Scofield H and Kurien B: Humana Press : USA 2009; Vol 536:89-93.

  • Radhakrishnana V.V, Annamma M, Sumi. MG. A Quarter century Experience with central nervous system infections. Chapter 19:2004 p. 227-254 in “SILVER LINES” edited by Kuruppath Radhakrishnan, Director, SCTIMST, Thiruvananthapuram, Kerala, India.

  • Radhakrishnan V,V, Annamma M. Immunoassays on Neurotuberculosis. Chapter in progress on pathology. Chapter XIII page 399-408:1997 Edited by B.N. Datta, Jaypee Brothers Medical Publishers, New Delhi, India.

Research Work
Title of Research Projects Research Project Undertaken/Involved and Funding Agency
Experimental Fungal Meningitis 1981-1983 State Council for Science, Technology and Environment, Thiruvananthapuram, Kerala, India
Immunological evaluation endomyocardial fibrosis 1983-1985 Department of Pathology, SCTIMST, Thiruvananthapuram, Kerala, India
Immunological evaluation of aorto arteritis.  1985-1986 Department of Pathology, SCTIMST, Thiruvananthapuram, Kerala, India
Immunodiagnosis of Tuberculous Meningitis.  1987-1994 Department of Pathology, SCTIMST, Thiruvananthapuram, Kerala, India
Development of an Immunodiagnostic system for Tuberculosis Meningitis suited to laboratories in developing countries. 1996-2002 Department of Science and Technology, New Delhi, India
Evaluation of Neutrophil chemotaxis and phagocytosis in periodontitis patients. 2003 University of Kerala, Dissertation for MDS – student Dental Collge, Thiruvananthapuram, Kerala, India
Evaluation of Cytokines in the pathogenesis and prognosis of Guillain Barre’syndrome. 1999-2002 Department of Biotechnology, New Delhi, India
Immunological evaluation in Myasthenia Gravis. 2003- 2007 State Council for Science, Technology and Environment, Thiruvananthapuram, Kerala, India
Identification of Mycobacterial tuberculous by in-situ  hybridization and demonstration of mycobacterial antigen in the CSF cytospin smears by an immunocytochemical study for the early laboratory diagnosis of TBM. 2006-2009 Department of Science and Technology, New Delhi, India
Evaluation of cord factor of Mycobacterium tuberculosis as a prognostic marker in patients with pulmonary tuberculosis. 2009-2012 State Council for Science, Technology and Environment, Thiruvananthapuram, Kerala, India
Trehalose 6-6’-dimycolate (cord factor) of M.tuberculosis and its role in the immunopathogenesis of murine tuberculosis. 2010-2012 Department of Science and Technology, New Delhi, India
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