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Dr. Bijo Mathew

Associate Professor

Dr. Bijo Mathew is an Associate Professor at the Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Kochi, India.

Bio

Dr. Bijo Mathew is Associate Professor of Pharmaceutical Chemistry at the Amrita School of Pharmacy, Kochi, India. Dr. Bijo Mathew obtained his M.Pharm in Pharmaceutical Chemistry from The Tamilnadu Dr. M.G.R. Medical University, Tamilnadu, India in 2008 and Ph.D. in Pharmaceutical Sciences from Jawaharlal Nehru Technological University, Hyderabad, India in 2016. Mathew’s primary areas of focus are in drug discovery of neurodegenerative disorders, cancer and molecular modelling. His main research interest is on the design of enzyme inhibitors, and especially MAOs, ChEs and BACE1. He has published 157 papers, [h-index = 31; the number of citations: 2517 in Google scholar; h-index = 31; the number of citations: 2128 in Scopus [August 2021]. With 13 years of teaching and research experience, Mathew authored 1 book, 1 edited book, 5 book chapters and 26 invited talk in national and international level. Dr. B. Mathew is serving as a chief executive guest editor of the journals of Molecules, Current Topics in Medicinal Chemistry, and Current Drug Targets. He is serving in the editorial board of Combinatorial Chemistry and High Throughput Screening. He received Amrita Vishwa Vidyapeetham Chancellor’s Publication Award in 2021. He received one patent from Korean Intellectual Property of Office in the topic of protective or therapeutic compositions of neurological disorders containing furano chalcones as effective agents.

Education

  • 2010-2016: Ph. D. (Pharmaceutical Science)
    Jawaharlal Nehru Technological University, Hyderabad, India.
    Title: Synthesis, Characterisation, and Pharmacological Evaluation of Some Heterocyclic Derivatives under the supervision of Dr. A. Jerad Suresh (Professor & Principal, Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai, India.)
  • 2006-2008: M. Pharm. (Pharmaceutical Chemistry)
    The Tamilnadu Dr. M. G. R. Medical University, Chennai, India.
  • 2001-2005: B. Pharm.
    The Tamilnadu Dr. M. G. R. Medical University, Chennai, India.
  • 1999-2001: Pre-degree
    Mahatma Gandhi University, Kottayam, India.

Area of Interest

  • Chemistry and biological exploration of various class of chalcones.
  • Synthesis of and pharmacological exploration of heterocyclic nucleus such as benzimidazole, thiadiazole, pyrimidine, furan, pyrazoline and thiazole etc.
  • CNS depressant, anticonvulsant, anticancer, antioxidant,antitubercular activity.
  • Design of MAO, Acetylcholinesterase and Hsp90 inhibitors.
  • Microwave assisted synthesis.
  • Structural elucidation of organic molecules by IR, NMR and MASS (mass fragmentation pattern) technique.
  • Molecular docking, Dynamics, Pharmacophore mapping, 3D-QSAR studies.
  • Isolation of natural secondary metabolites from medicinal plant and their insilico studies.

Expert in Drug Design Softwares

  • AutoDock4.2, Molegrow, Arguslab, Hex, LigandScout, Open-Babel, Accelery Discovery, Chem-3D.

Section Editor

  • Coronaviruses [BenthamScience]

Editorial Member

  • Combinatorial Chemistry & High Throughput Screening [BenthamScience]

Chief Executive Guest Editor

  1. Molecules [MDPI] [Impact Factor®:4.4].
    Title of the thematic issue: Recent drug design strategy of the design of molecules against Alzheimer’s disease and Parkinson’s diseases . [Issue under Preparation].
  2. Current Topics in Medicinal Chemistry [Bentham Science] [Impact Factor®:3.3].
    Title of the thematic issue: SAR analysis of various heterocyclic compounds in medicinal chemistry: Recent Updates. [Issue under Preparation].
  3. Current Drug Targets [BenthamScience] [Impact Factor®:2.64].
    Title of the Thematic Issue: Mitochondrial dysfunction and traffic jams in neurodegenerative disorders. [BenthamScience] [Issue under Preparation].
  4. Combinatorial Chemistry & High Throughput Screening [BenthamScience] [Impact Factor®:1.56].
    Title of the Thematic Issue: Inhibitors of Monoamine Oxidase and Acetylcholinesterase as a front runner in CNS drug discovery [Issue under preparation-2020].
  5. Combinatorial Chemistry & High Throughput Screening [BenthamScience] [Impact Factor®:1.56].
    Title of the Thematic Issue: Computational chemistry andsynthetic strategy of the design of novel Monoamine oxidase inhibitors. [2017, 20, 459-578]
  6. Central Nervous System Agents in Medicinal Chemistry [BenthamScience]
    Title of the Thematic Issue: Rational approaches for the design of Monoamine Oxidase Inhibitors [2016, volume 16, Issue 2- Page no: 73-164]

Projects under Supervision

  • B. Pharm. level – 11
  • M. Pharm. level – 1
  • Ph. D.- 4 (ongoing)
Publications

Book

Medicinal Chemistry –II

Authors : Dr. Bijo Mathew, Dr. Manjinder Singh;

Publisher : Doonville Publishers (P) Ltd

Book Chapter

Neurochemicals in Nervous System and Exploring the Chemical Make-Up of Human Brain

Authors : Dr. Bijo Mathew, Harilal, Seetha; Kumar, Rajesh; Mathew, Githa Elizabeth; Jose, Jobin; Uddin, Md. Sahab

Publisher : Principles of Neurochemistry: Fundamentals and Applications

Teaching Experience
Year Affiliation
Present Associate Professor, Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Kochi, India.
November 11, 2015 – October 31, 2020 Associate Professor, Ahalia School of Pharmacy, Palakkad, India.
Subjects Taught:
– Pharmaceutical Organic Chemistry (B. Pharm.)
– Medicinal Chemistry (B. Pharm.)
November 23, 2009 – October 31, 2015 Assistant Professor, Grace College of Pharmacy, Palakkad, India.
Subjects Taught:
– Pharmaceutical Organic Chemistry (B. Pharm.)
– Medicinal Chemistry (B. Pharm.)
– Advanced Medicinal Chemistry (M. Pharm.)
August 18, 2008 – July 29, 2009 Lecturer, Nehru College of Pharmacy, Thrissur, India.
Subjects Taught:
– Pharmaceutical Organic Chemistry
– Medicinal Chemistry
Workshops and Trainings Attended
No. Area Venue Duration
1. Computer-aided drug design seminar and hands-on training of GLIDE software College of Pharmacy, Madras Medical College, Chennai, India. January 4-5, 2011
2. Course Work on “Research Methodology  J.N.T.U. Hyderabad, India. June 6-11, 2011
3. National  workshop on NMR spectroscopy: Theory, Principle and instrumentation  IIRBS Mahatma Gandhi University, Kottayam, India. September 10-13, 2014
4. Role of Indian Regulators and Pharma Industry 66th Indian Pharmaceutical Congress-Hyderabad, India. January 23-25-, 2015
Invited Talks
International Level
No. Topic Year and Venue
1. Chalcone chemistry towards monoamine oxidase enzyme inhibition: Development of new class of Anti-Alzheimer’s agents July 1, 2019 – International Multidisciplinary Symposium on Drug Research and Development-Inonu University-Malatya-Turkey
National Level
No. Topic Year and Venue
1. Extraction of Phytochemicals and their Importance 2009 – Nehru College of Pharmacy, Thrissur, Kerala, India.
2. Utilization of Open-source Software for the Drug Discovery Process 2013 – College of Pharmacy, Madras Medical College, Chennai, India.
3. Utilization of Computational Tools in Drug Discovery August 24, 2013 – Jamia Salifia Pharmacy College, Pulikal, Kerala, India.
4. Drug Receptor Interaction and Hands-on Training of AutoDock4.2. and its Interpretation January 31, 2014 – College of Pharmacy, Madras Medical College, Chennai, India.
5. Workshop on Docking Studies of Synthetic Molecules April 3, 2014 – Devaki Amma Memorial College of Pharmacy, Malappuram, Kerala, India.
6. Basic Principles of Drug Design and QSAR Approach April 28, 2015 – Moulana College of Pharmacy, Perinthelmanna, Kerala, India.
7. Rational Approaches of Drug Design and Introduction of CADD February 20, 2016 – Malik Deenar College of Pharmacy, Kasaragod, Kerala, India.
8. Workshop on the Design and Docking Studies of MAO Inhibitors (AutoDock Tools) June 25, 2016 – College of Pharmacy, Madras Medical College, Chennai, India.
9. Introduction to Drug Design and Drug Development October 19, 2016  – National College of Pharmacy, Calicut, Kerala, India.
10. Integrated View of Structure-based Drug Design of Newer Molecules November 18, 2016 – Karpagam University, Coimbatore, India.
11. Principles of Drug Design and Introduction of CADD November 25, 2017 – Srikrishna College of Pharmacy, Trivandrum
12. Relevance of Molecular Docking in Drug Design December 17, 2017 – National College of Pharmacy, Calicut, Kerala, India.
13. Workshop on the Docking Studies of MAO-B Inhibitors (AutoDock Tools) January 20, 2018 – National College of Pharmacy, Calicut, Kerala, India.
14. Seminar cum Workshop on the Docking Studies of (AutoDock Tools) February 24, 2018 – KVM College of Pharmacy, Cherthala, Kerala, India.
15. Seminar cum Workshop on the Docking Studies of (AutoDock Tools) February 22, 2019 – Devaki Amma Memorial College of Pharmacy, Malappuram, Kerala, India.
16. An Overview on Molecular Docking and QSAR Febraury 23, 2019 – Swamy Vivekanda College of Pharmacy, Tamilnadu, India.
17. Introduction of Drug Design and Protein Target Prediction October 19, 2019 – College of Pharmacy, Madras Medical College, Chennai, India.
18. Seminar cum Workshop on AutoDock based Drug Design October 26, 2019 – Nirmala College of Pharmacy, Muvatupuzha, Kerala India.
19. Perspectives of Drug Design Project in an Academic Scenario: Where We Stand Now & What We Can Do? November 2, 2019 – National College of Pharmacy, Calicut, Kerala, India.
20. Ligand-based Drug Design Special Emphasis with 2D and 3D QSAR December 10, 2019 – Thanthai Rover college of Pharmacy, Perambalur, Tamilnadu, India.
21. Research Methodology: A Process from Literature Review to Thesis Writing January 18, 2020 – National College of Pharmacy, Calicut, Kerala, India
22. Drug Design Principles and Molecular Docking Techniques June 5, 2020 – Vinayaka Mission’s College of Pharmacy, Salem, Tamilnadu, India.
23. Drug Reposition: Transformation on Hard Work to Mart Work August 22, 2020 – Nirmala College of Pharmacy, Muvatupuzha, Kerala India.
24. Over-view of drug receptor interactions 31-5-2021 & National Webinar organised by Dr. M.G.R. Educational and Research Institute , Chennai, India.
25. Research Methodology 11-06-2021 & the National Webinar organised by Vinayaka Mission’s University, Salem, India.
26. Writing techniques of a medicinal chemistry research paper in a peer-reviewed journal 31-05-2021 & the National FDP AICTE Sponsored Program organised by National College of Pharmacy, Calicut, India.
International and National Collaborative Research Program Carried out
  1. National Institute of Neurological Disorders and Syndrome (NINDS), National Institute ofHealth (NIH), Bethesda, MD 20892-9020, USA.
  2. Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Sýhhiye 06100, Ankara, Turkey. (WithProf. Dr. G. Uçar).
  3. Department of pharmacy and research institute of life Pharmaceutical Sciences, Sunchon National University, Suncheon 579922, Republic of Korea (Prof. Dr. Hoon Kim)
  4. Laboratory of Molecular & Cellular Biology, Department of Biological Chemistry-IQUIBICEN, Natural Exact Sciences School, University City,University of Buenos Aires, Buenos Aires (C1428EGA),Argentina. (WithProf. Dr. M. D. Galigniana).
  5. School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4001, South Africa.(WithProf. Dr. M. E. S. Soliman).
  6. Department of Pharmaceutical Chemistry and Centre of Excellence for Pharmaceutical Sciences, School of Pharmacy, North-West University, Private Bag X6001,Potchefstroom 2520,South Africa.(WithProf. Dr. J.P. Petzer).
  7. Universidade Federal Rural do Rio de Janeiro, Departmento de Quimica. Brazil
  8. Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy (WithProf. Dr. S. Carradori).
Professional Recognition as an Examiner for Ph.D. & P.G.
  1. “Design, Synthesis and evaluation of new chemical scaffolds as potential anti-cancer agents” by Ms. M. Bhagyalalitha2019 (External Expert in Ph.D.). JSS Academy of Higher Education and Research(Deemed to be University). Mysuru, India.
  2. Doctor of Philosophy Thesis evaluator2017. (International Evaluator) of‘The dual role of cathepsin-d in breast cancer and hiv neuropathogenesis’by O.A. Arodola (Reg No:213569288) under the supervision of Prof. M.E.S. Soliman [School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4001, South Africa.]
  3. Doctor of Philosophy Thesis evaluator2017. (International Evaluator) of‘Application of advanced computational tools towards the understanding of TB targets and design of potential drug candidates’by Kgothatso E. Machaba (Reg No:215082344) under the supervision of Prof. M.E.S. Soliman [School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4001, South Africa.]
  4. Post Graduate Thesis evaluator2017. (International Evaluator) of‘Designing of novel HIV/TB Inhibitors Using In silico Drug Design Approaches’ by Lauren Blake (Reg No: 21357002) under the supervision of Prof. M.E.S. Soliman [School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4001, South Africa.]
Research Fund of Sponsored Projects

International Level Minor

  • Design of new class of halogenated cinnamoyl derivatives as selective monoamine oxidase –B inhibitors by similarity based drug design. [International consultant] Deanship of scientific research (DSR), King Khalid University, Abha, Kingdom of Saudi Arabia. 20000 S.R. [2020]. Project No: 23/1441. Completed.
  • Design, synthesis of Sulphur and nitrogen containing α-β- unsaturated ketones as a new multitarget ligands for the treatment of Alzheimer’s disease.’ [Co-Investigator] Deanship of scientific research (DSR), King Khalid University, Abha, Kingdom of Saudi Arabia. 20000 S.R. [2021]. Project No: 159/42. Ongoing.

National Level Minor

  • Development of Multi-conjugated ketones as the development of new class of dual acting MAO/AChE inhibitors for the treatment of Alzheimer’s disease. [Principal Investigator] [Amrita Vishwa Vidyapeetham, Kochi, India, Seed Grant- 5 Lakhs [2020]. Grant Number K‐PHAR‐20‐628]. Ongoing.
  • Development and fine-tuning of methoxylated α,β-unsaturated ketones as monoamine oxidase inhibitors. Synthesis, biochemistry and computational study. [Principal Investigator] [Kerala State Council for Science, Technology & Environment – 10000 Rs. [2016].File No: 1/SPS-59/2016/CSTE. Completed.
  • Synthesis, in silico design and anticonvulsant screening of some novel thiophene based hydrazone derivatives. [Principal Investigator] [Kerala State Council for Science, Technology & Environment – 10000 Rs. [2014].File No: 77/SPS-52/2014/CSTE. Completed.
  • Development of some new trans-1, 3- substituted diphenyl-2-propen-1-ones as Monoamine Oxidases Inhibitors: An in vitro and in vivo study. [Co- Investigator] [Kerala State Council for Science, Technology & Environment – 10000 Rs. [2015].File No: 01/SPS-54/2015/CSTE. Completed.
Honorarium Received

Honorarium Received

  • Received 400 US dollars in connection with the Guest Editor of the journal ofCentral Nervous System Agents in Medicinal Chemistry [BenthamScience]. Cheque no: 179832121 (Dated 2016 July 31).
  • Received 600 US dollars in connection with the Guest Editor of the journal of Combinatorial Chemistry and High throughput Screening [Bentham Science]. Cheque no: 179832121 (Dated 2021 February 16).

Awards Received

  • Amrita Innovation and Research Awards: [2021] Received Chancellor’s Publication Award
  • Amrita Innovation and Research Awards: [2021] Received Publication Merit award.
  • Received Best Resource Person award in 2021 at National College of Pharmacy in AICTE and learning (ATAL) academy sponsored FDP program

Research Publication

  • Scopus ID: 3700005470
  • Researcher ID is: G-7477-2014
  • Scopus citation: 2128
  • H-index: 29 [Scopus]
  • Google scholar citation: 2517
  • H-index: 31 [Google scholar]
  • i10-index: 74 [Google scholar]
Cumulative Impact Factor: 434.38 [Based on 2021 JCR reports]
NO Journal Title Publisher Impact factor No. of papers
1 Science of the Total Environment Elsevier 7.96 2
2 Current Neuropharmacology Bentham 7.36 1
3 International Journal of Biological Macromolecules Elsevier 6.95 3
4 Oxidative Medicine and Cellular Longevity Hindawi 6.54 2
5 Biomedicine and Pharmacotherapy Elsevier 6.52 1
6 European Journal of Medicinal Chemistry Elsevier 6.51 3
7 Pharmaceutics MDPI 6.30 1
8 Journal of Molecular liquids Elsevier 6.16 2
9 International Journal of Molecular Science MDPI 5.92 1
10 Pharmaceuticals MDPI 5.86 2
11 Molecular Neurobiology Springer 5.50 3
12 Bioorganic Chemistry Elsevier 5.27 2
13 Neural Regeneration Research Medknow 5.13 1
14 Journal of Enzyme Inhibition and Medicinal Chemistry Tailor and Francis 5.05 2
15 Life Science Elsevier 5.03 1
16 Current Medicinal Chemistry Bentham 4.53 3
17 Molecules MDPI 4.41 4
18 CNS and Neurological Disorders and Drug Targets Bentham 4.40 2
19 Environmental Science and Pollution Research Springer 4.22 6
20 Drug Design Development Therapy Dove Press 4.16 1
21 Brain Research Bulletin Elsevier 4.07 1
22 Excli Journal University of Mainz 4.06 1
23 Neurochemical Research Springer 3.99 1
24 Journal of Saudi Chemical Society Elsevier 3.93 2
25 Neurotoxicity Research Springer 3.91 1
26 ACS Combinatorial Science ACS 3.78 1
27 Journal of Pharmacy and Pharmacology Wiley 3.76 3
28 Process  Biochemistry Elsevier 3.76 1
29 Archiv de Pharmazie Wiley 3.75 4
30 MedChemCommun [RSC Medicinal Chemistry] RSC 3.59 1
31 Journal of Biomaterial Research Part A Wiley 3.52 1
32 ACS OMEGA ACS 3.51 1
33 Current Drug Targets Bentham 3.46 3
34 ChemMedChem Wiley 3.46 4
35 Current Topics in Medicinal Chemistry Bentham 3.29 2
36 Current Protein and Peptide Science Bentham 3.27 1
37 IUMB life Wiley 3.24 1
38 Journal of Molecular Structure Elsevier 3.19 4
39 Journal of Neurological Sciences Elsevier 3.18 1
40 Current Pharmaceutical Design Bentham 3.11 7
41 Journal of Physical Chemistry B ACS 2.99 1
42 Chemical Biology and Drug Design Wiley 2.81 1
43 Immunopharmacology and  Immunotoxicology Tailor and Francis 2.73 1
44 Applied Sciences MDPI 2.67 1
45 Evidence based Complementary and Alternative Medicine Hindawi 2.62 1
46 Mini Reviews in Organic Chemistry Bentham 2.49 1
47 Chemistry and Biodiversity Wiley 2.40 1
48 ChemistrySelect Wiley 2.10 7
49 Medicinal Chemistry Research Springer 1.96 1
50 Combinatorial Chemistry and High Throughput Screening Bentham 1.33 8
51 Acta Crystallographica Section C Wiley 1.17 1
52 Letters in Drug Design and Discovery Bentham 1.15 3
53 Indian Journal of Pharmaceutical Sciences MedKnow 0.97 2
54 Bangladesh Journal of Pharmacology BPS 0.93 1
55 Letters in Organic Chemistry Bentham 0.86 1
56 Indian Journal of Heterocyclic Chemistry NACB-India 0.34 1
Category Number of Papers Published
First Author cum Corresponding Author: 58
Corresponding Author 117
Co-Author 40
Single-Author: 2
Total 157
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