ProgramsView all programs
From the news
- Chancellor Amma Addresses the Parliament of World’s Religions
- Amrita Students Qualify for the European Mars Rover Challenge
Publication Type : Journal Article
Publisher : Chemical Sciences Journal
Source : Chemical Sciences Journal (2012)
Keywords : Anti-Inflammatory Agents, Plant biochemistry, Roots (Botany), Solanum
Campus : Kochi
School : School of Pharmacy
Department : Pharmaceutical Chemistry & Analysis
Year : 2012
Abstract : The aim of our research was the isolation of the steroidal alkaloid glycosides such as anguivine and isoanguivine from the dried roots of S. anguvi and evaluation of their anti-inflammatory activity by HRBC and carrageenan induced paw edema method. The PASS programme predicts the anti-inflammatory activity of the aglycon part of spirosolenol, on the basis of a similarity structure based drug design. Molecular docking studies with human phospholipase A2 enzyme were carried outby utilizing Argus lab 4.0.1.version. The in silico study and pharmacological activity were correlated with good agreement.
Cite this Research Publication : Bijo Mathew, Mathew, G. E., George, S., Shamnas, M., and Raj, V. B. A., “Isolation, in silico design and anti-inflammatory activity of spirosolenol from the roots of Solanum anguvi”, Chemical Sciences Journal, 2012.