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Dr. Wesely M. Jose

Clinical Professor, Department of Medical Oncology, School of Medicine, Kochi

Qualification: DNB, MBBS, MD, PGDM
wesleymjose@aims.amrita.edu

Bio

Dr. Wesley M. Jose joined Amrita Institute of Medical Sciences in April 2008. He currently serves as Professor at the Department of Medical Oncology and Hematology at Amrita Institute. Dr. Wesley did his medical training from Christian Medical College and Hospital, Ludhiana, Punjab. Prior to joining Amrita, he worked as an Assistant Professor at the Department of Medicine at the Christian Medical College and Hospital, Ludhiana. His core research interests lie in Neuro-oncology. He is an academician. He has presented several scientific papers and continues to be an invited faculty for various oncology conferences. His primary clinical practice areas include: – Breast Cancer, Brain Tumors (Ault and Pediatric), Gastrointestinal malignancies, Multiple Myeloma, Lymphoma and Pediatric solid cancers.

Qualification :MBBS, MD (Internal Medicine), DNB (Medical Oncology), MNAMS, FIACM, PGDIM

Speciality : Medical Oncology, Neuro-Oncology, Amrita Cardio Oncology Clinic

Publications

Conference Proceedings

Year : 2023

PD-0895 Response and survival function correlation with CyberKnife in 209 HCC pt with portal vein thrombus

Cite this Research Publication : Dutta D, Sreenija Y, Reddy S, Nair H, SK N, Sasidharan A, Kannan R, George S, EH A, Haridas NK, Jose W. PD-0895 Response and survival function correlation with CyberKnife in 209 HCC pt with portal vein thrombus. In ESTRO 2023, Vienna, Austria. Radiotherapy and Oncology. 2023 May 1;182:S741-2.

Year : 2023

27P Treatment outcomes and toxicity profiles in South Asian patients of high-risk endometrial cancer treated with PORTEC-3 trial regimen

Cite this Research Publication : P Verma, A Sasidharan, S Kalavagunta, K Pavithran, W Jose, N Haridas, P RM, A Rajanbabu, P Bhati, D Dutta. 27-P Treatment outcomes and toxicity profiles in South Asian patients of high-risk endometrial cancer treated with PORTEC-3 trial regimen. In ESMO 2023. https://doi.org/10.1016/j.esmoop.2023.100798

Publisher : ESMO Open

Year : 2021

Triple intrathecal chemotherapy for leptomeningeal carcinomatosis in solid tumors: Treatment outcomes, response and their determinants

Cite this Research Publication : Srinivasalu V K, Subramaniam N, Philip A, Jose W, Pavithran K (2018) Triple intrathecal chemotherapy for leptomeningeal carcinomatosis in solid tumours In: ESMO Asia 2018. Annals of Oncology (2018) 29 (suppl_9): ix21-ix22, https://doi.org/ 10.1093/annonc/mdy429

Publisher : National Library of medicine

Year : 2021

Dihydropyrimidine dehydrogenase deficiency in patients treated with 5FU or capecitabine based regimens: A single center experience from South India.

Cite this Research Publication : Pavithran K, Ariyannur P, Jayamohanan H, Philip A, Jose WM, Soman S. Dihydropyrimidine dehydrogenase deficiency in patients treated with 5FU or capecitabine based regimens: A single center experience from South India. In ASCO 2021. 10.1200/JCO.2021.39.15_suppl.e15517

Publisher : Journal of Clinical Oncology

Year : 2021

847P The utility of serum amylase as a clinical marker in patients with multiple myeloma

Cite this Research Publication : C. Panthula, W.M. Jose, S. Krishnan. 847P The utility of serum amylase as a clinical marker in patients with multiple myeloma. In ESMO 2021. https://doi.org/10.1016/j.annonc.2021.08.140

Publisher : Elsevier

Year : 2021

256P PI3K mutation is associated with reduced sensitivity to CDK4/6 inhibitors in metastatic breast cancer

Cite this Research Publication : Pavithran K, Jayamohanan H, Jose WM, Soman S, Vijaykumar DK, Ariyannur PS. 256P PI3K mutation is associated with reduced sensitivity to CDK4/6 inhibitors in metastatic breast cancer. In ESMO 2021. Annals of Oncology. 2021 Sep 1;32:S471.

Publisher : ESMO

Year : 2020

Something Blue, Something Borrowed: A Challenging Case Series

Cite this Research Publication : Satheesh Malavika, Paulose Roopa, Nambiar Ajit, Nair Indu, George Archana, Pillai Bhanu, Jose Wesley M. Something Blue, Something Borrowed: A Challenging Case Series. In Indian Association of Pathologists and Microbiologists - Kerala Chapter 85th Meeting. 2020.

Year : 2020

Neoadjuvant chemotherapy in muscle invasive bladder cancer: Real world data on safety and outcome.

Cite this Research Publication : Sree Vamsee Chetana Panthula, Arun Philip, Pavithran Keechilat, Wesley Mannirathil Jose. Neoadjuvant chemotherapy in muscle invasive bladder cancer: Real world data on safety and outcome. In ASCO 2020. DOI: 10.1200/JCO.2020.38.15_suppl.e17036

Publisher : American Society of Clinical Oncology Publications Log In Submit E-Alerts Cart

Year : 2019

Second malignancies with breast cancer: An audit

Cite this Research Publication : Srinivasalu VK, Subramaniam N, KS S, Kolathu S, Philip A, Jose WM, Kunheri B, Pavithran K. Second malignancies with breast cancer: An audit. In ESMO 2019. Annals of Oncology. 2019 May 1;30:iii67-8.

Publisher : Annals of Oncology

Year : 2019

Thromboembolic events in advanced non-small cell lung cancer

Cite this Research Publication : VK Srinivasalu, N Subramaniam, S Raghuram, S Kolathu, B Ponnada, A Philip, WM Jose, K Pavithran. Thromboembolic events in advanced non-small cell lung cancer. In ESMO 2019. https://doi.org/10.1093/annonc/mdz063.018

Publisher : Annals of Oncology

Year : 2019

Clinical significance of BCL-2 with basal and non-basal triple negative breast cancer (TNBC).

Cite this Research Publication : Srinivasalu VK, Susan A, Philip A, Jose WM, Nv S, Nambiar A, Pavithran K. Clinical significance of BCL-2 with basal and non-basal triple negative breast cancer (TNBC). In ESMO 2019. Annals of Oncology. 2019 May 1;30:iii46.

Publisher : Elsevier

Year : 2019

Prognostic significance of BCL-2 expression in triple negative breast cancer (TNBC)

Cite this Research Publication : Srinivasalu VK, Susan A, Jose WM, Philip A, Nv S, Nambiar A, Pavithran K. Prognostic significance of BCL-2 expression in triple negative breast cancer (TNBC). In ESMO 2019. Annals of Oncology. 2019 May 1;30:iii14.

Publisher : Elsevier

Year : 2019

Evaluation of outcome and prognostic factors in paediatric extraskeletal ewings sarcoma: A single institution experience.

Cite this Research Publication : Vijay Kumar Srinivasalu, Hari Sankaran, Narayana Subramaniam, Arun Philip, Wesley Mannirathil Jose, Pavithran Keechilat. Evaluation of outcome and prognostic factors in paediatric extraskeletal ewings sarcoma: A single institution experience. In ASCO 2019. 10.1200/JCO.2019.37.15_suppl.e21507

Publisher : Journal of Clinical Oncology

Year : 2018

mFLOT versus EOX in first line treatment of metastatic carcinoma of stomach

Cite this Research Publication : Srinivasalu V K, Subramaniam N, Jose W, Philip A, Pavithran K (2018) mFLOT versus EOX in first line treatment of metastatic carcinoma of stomach. In: ESMO Asia 2018. Annals of Oncology, Volume 29, Issue suppl_9, 1 November 2018, mdy432.015, https://doi.org/10.1093/annonc/mdy432.015

Publisher : Elsevier

Year : 2017

Immune Modulation in Cancer

Cite this Research Publication : Jose W (2017). Immune Modulation in Cancer. In: International Conference on Immune Response in Health and Disease. Kerala

Year : 2017

Effect of obesity on the toxicity profile of patients with breast cancer treated with adjuvant chemotherapy.

Cite this Research Publication : Srinivasalu V K, George AS, Philip A, Kotne S, Bhambroo S, Vijaykumar DK, Pillai R, Beena K, Jose W, Pavithran K (2017) Effect of obesity on the toxicity profile of patients with breast cancer treated with adjuvant chemotherapy. In: ASCO 2017. J Clin Oncol 35, 2017 (suppl; abstr e12033)

Publisher : Journal of Clinical Oncology

Year : 2017

Independent predictors of one year mortality in patients with primary systemic immunoglobulin light chain cardiac amyloidosis In: ESMO Congress2017

Cite this Research Publication : Srinivasalu V K, Subramaniam M, Shanmugam A, Philip A, Susan A, Prabhu R, Unni M, Sidharthan N, Jose W, Smitha NV, Ahamed H, Mathew N, Keechilat P (2017) Independent predictors of one year mortality in patients with primary systemic immunoglobulin light chain cardiac amyloidosis In: ESMO Congress2017. Annals of Oncology (2017) 28 (suppl_5): v355-v371. https://doi.org/10.1093/annonc/mdx373

Year : 2017

1077P – Do patients over 70 years with advanced head and neck squamous cell carcinoma tolerate curative intent concurrent chemo-radiation? Predictors of oncological outcomes

Cite this Research Publication : Srinivasalu V K, Subramaniam N, Kumar N, Balasubramaniam D, Philip A, Susan A, Remesan Nair A, Prameela CG, Pushpaja KU, Thankappan K, Jose W, Iyer S, Pavithran K (2017) Do patients over 70 years with advanced head and neck squamous cell carcinoma tolerate curative intent concurrent chemo-radiation? Predictors of oncological outcomes In: ESMO Congress 2017. Annals of Oncology, Volume 28, Issue suppl_5, 1 September 2017, mdx374.033, https://doi.org/10.1093/annonc/mdx374.033

Publisher : Elsevier

Year : 2017

The Changing Paradigm of Pediatric Medulloblastoma in Kerala; Improved Outcomes with New Challenges

Cite this Research Publication : Kotne S, Philip A, Pillai R, Jose W, Menon D, Pavithran K, Sankaran H. The Changing Paradigm of Pediatric Medulloblastoma in Kerala; Improved Outcomes with New Challenges. In Pediatric Blood & Cancer 2017; 64: S312-S312)

Publisher : Research Gate

Year : 2017

Response and Survival in Newly Diagnosed Multiple Myeloma Patients Treated with Cybord Regimen Using Generic Bortezomib — Data from Two Centres from India

Cite this Research Publication : Sidharthan N, Sivadas A, Devasia AJ, Kulkarni UP, Sudevan R, Pavithran K, Prabhu R, Ganapathy R, Philip A, Jose W, Unni M. Response and Survival in Newly Diagnosed Multiple Myeloma Patients Treated with Cybord Regimen Using Generic Bortezomib—Data from Two Centres from India. Blood. 2017 Dec 8;130:5398.

Publisher : Blood

Year : 2017

317O – Bortezomib based versus melphalan based regimen as induction chemotherapy for primary AL amyloidosis with cardiac involvement and factors predicting early mortality

Cite this Research Publication : Srinivasalu V K, Subramaniam M, Shanmugam A, Philip A, Susan A, Prabhu R, Unni M, Sidharthan N, Jose W, Smitha NV, Pavithran K (2017) Bortezomib based versus melphalan based regimen as induction chemotherapy for primary AL amyloidosis with cardiac involvement and factors predicting early mortality In: ESMO Asia Congress. Singapore 664. Annals of Oncology, Volume 28, Issue suppl_10, 1 November 2017, mdx664, https://doi.org/10.1093/annonc/mdx664

Publisher : Elsevier

Year : 2016

Treatment outcome in Medulloblastoma with the POG9031 protocol: A single institution review.

Cite this Research Publication : Philip A, Muniratnam V, Jose W, Durgapoorna, Dinesh M, Bindhu MR, Pavithran K (2016) Treatment outcome in Medulloblastoma with the POG9031 protocol: A single institution review. In: ESMO 2016, Copenhagen.

Year : 2016

Analysis of EGFRvIII and EGFR exon 19 overexpression in Glioma and its prognostic significance

Cite this Research Publication : Muniratnam V, Philip A, Bindhu MR, Dinesh M, Pavithran K, Jose W (2016) Analysis of EGFRvIII and EGFR exon 19 overexpression in Glioma and its prognostic significance. In: ESMO 2016, Copenhagen. https://doi.org/10.1093/annonc/mdw367.20

Year : 2016

Short-Course Lenalidomide Plus Low-Dose Dexamethasone in the Treatment of Newly Diagnosed Multiple Myeloma—A Single-Centre Pragmatic Study

Cite this Research Publication : Jose W, Pavithran K, Ganesan TS (2016) Short course Lenalidomide plus Low Dose Dexamethasone in the Treatment of Newly Diagnosed Multiple Myeloma – A Single Center prospective study with five years follow up. In: IACMCON 2016, Gwalior.

Publisher : MDPI

Year : 2016

Is triple negative breast cancer really bad? 10 year audit from a tertiary center

Cite this Research Publication : Chelakkot PG, Ravind R, S. K, Jose WM (2016). Is triple negative breast cancer really bad? 10 year audit from a tertiary center. In: ESMO Asia 2016 Congress, Singapore. Annals Oncol (2016) 27 (suppl_9): mdw602.008.; https://doi.org/10.1093/annonc/mdw602.008

Year : 2016

Outcomes of Treatment of Glioblastma Multiforme: A single institution experience from South India (Ten year audit from a tertiary centre)

Cite this Research Publication : George A S, Philip A, Jose W, Durgapooorna, Bindhu MR, Pillai A, Pavithran K (2016) Outcomes of Treatment of Glioblastma Multiforme: A single institution experience from South India (Ten year audit from a tertiary centre). In: ESMO Asia, Singapore.

Year : 2016

Prognostic Significance of EGFRvIII and EGFR exon 19 overexpression in Glioblastoma mutiforme in Indian patients

Cite this Research Publication : Jose W, Muniratnam V, Pavithran K, (2016) Prognostic Significance of EGFRvIII and EGFR exon 19 overexpression in Glioblastoma mutiforme in Indian patients. In: IACMCON 2016, Gwalior.

Year : 2015

Effectiveness of addition of olanzapine to standard antiemetic regimens in patients receiving emetogenic chemotherapy

Cite this Research Publication : Vijayalakshmi S, Emmanuel J, Jose WM (2015) Effectiveness of addition of olanzapine to standard antiemetic regimens in patients receiving emetogenic chemotherapy In: 66th IPC, Hyderabad

Year : 2015

Neutrophil to lymphocyte ratio predicts lymph node metastasis in triple negative breast cancer.

Cite this Research Publication : Philip A, Pavithran K, Jose M, Wesley J, Renjini P, Vijaykumar DK, Dinesh M, Annie J, Seethalakshmi N, Smitha N. P245 Neutrophil to lymphocyte ratio predicts lymph node metastasis in triple negative breast cancer. The Breast. 2015(24):S110.

Year : 2015

Efficacy of fixed low dose rasburicase in the prevention and treatment of tumor lysis syndrome

Cite this Research Publication : Antony R, Lakshmi S, Sivadas A, Jose WM, Sidharthan N, Pavithran K. Efficacy of fixed low dose rasburicase in the prevention and treatment of tumor lysis syndrome. J Pharm Res. 2015;1: 46.

Year : 2014

Analysis of clinical profile and outcome of patients with hematological disorders and intracranial bleed

Cite this Research Publication : Sidharthan N, Krishnan N, Suhas S, Shenoy P, Jose M, Jose W, Pavithran K (2014). Analysis of clinical profile and outcome of patients with hematological disorders and intracranial bleed. (Abstract H012). 5th International Hematologic Malignancies Conference. Bridging the Gap 2014, Taipei, Taiwan.

Year : 2013

Association of Hodgkins Lymphoma with Epstein Barr Virus – A clinicopathological study from a tertiary care centre in Kerala

Cite this Research Publication : Indu R Nair, Pavithran K, Annie J, Jose W (2013). Association of Hodgkins Lymphoma with Epstein Barr Virus – A clinicopathological study from a tertiary care centre in Kerala. Indian Cancer Congress, New Delhi.

Year : 2013

Low dose Rasburicase is effective in treatment of adults with tumor lysis syndrome

Cite this Research Publication : Pavankumar B, Pavithran K, Jose W, Anita S, Sidharthan N (2013). Low dose Rasburicase is effective in treatment of adults with tumor lysis syndrome. Indian Cancer Congress, New Delhi.

Year : 2013

mStudy of prognostic significance of Neutrophilic / Lymphocytic ratio in patients with Diffuse large B cell lymphoma (DLBCL) treated with RCHOP or CHOP

Cite this Research Publication : Jose M, Boyella PK, Krishnan N, Sidharthan N, Jose W, Pavithran K (2013)mStudy of prognostic significance of Neutrophilic / Lymphocytic ratio in patients with Diffuse large B cell lymphoma (DLBCL) treated with RCHOP or CHOP. In: Indian Cancer Congress, New Delhi.

Year : 2011

Phase II study of Lenalidomide and short course Dexamethasone in Newly detected Multiple Myeloma

Cite this Research Publication : Jose W, Palaniappan M, Abdul Majeed, Kishore Kumar, K. Pavithran, T S Ganesan. Phase II study of Lenalidomide and short course Dexamethasone in Newly detected Multiple Myeloma. Indian Association of Cancer Research – Annual conference 2010, Kochi.

Year : 2011

Association of Tumor necrosis factor alpha – single nucleotide polymorphisms with multiple myeloma

Cite this Research Publication : Jose W, Krishnapriya S, Nagare RP, Pavithran K, Ganesan TS (2011) Association of Tumor necrosis factor alpha - single nucleotide polymorphisms with multiple myeloma. AACR International Conference titled New Horizons in Cancer Research: Biology to Prevention to Therapy 2011, Gurgaon.

Year : 2010

The association of Jak-2 V617f mutation with polycythemia rubra vera in Asian Indians

Cite this Research Publication : Unnikrishnan A, Sreedharan S, Jose W, Palaniappan M, Prabhu R, Unni M, Pavithran K, Bhaskaran S, Ganesan TS. The association of Jak-2 V617f mutation with polycythemia rubra vera in Asian Indians. Indian Association of Cancer Research – Annual conference 2010, Kochi.

Year : 2009

Safety and efficacy of Oxaliplatin and Capecitabine as first line therapy in recurrent or metastatic colorectal cancer

Cite this Research Publication : Majid A, Kishore K, Jose W, Ganesan TS. Safety and efficacy of Oxaliplatin and Capecitabine as first line therapy in recurrent or metastatic colorectal cancer. International Oncology Conference 2009, Kottayam.

Year : 2009

Esthesioneuroblastoma – A clinical profile

Cite this Research Publication : Kumar K, Unnikrishnan A, Jose W, Ganesan TS. Esthesioneuroblastoma – A clinical profile. ISMPO annual conference 2009, Chennai.

Year : 2009

Relapsed Acute Lymphoblastic Leukemia.

Cite this Research Publication : Kumar K, Unnikrishnan A, Jose W, Ganesan TS. Relapsed Acute Lymphoblastic Leukemia. ISMPO Conference 2009, Chennai

Year : 2009

Role of Skeletal Scintigraphy as a standard staging investigation in patients with NSCLC

Cite this Research Publication : Kumar K, Unnikrishnan A, Jose W, Ganesan TS. Role of Skeletal Scintigraphy as a standard staging investigation in patients with NSCLC. RGCON 8th International Conference, 2009, New Delhi.

Book Chapter

Year : 2018

Oncology – A nascent but wholesome science

Cite this Research Publication : Jose W. Oncology – A nascent but wholesome science. In, Dipanjan Bandopadhyay (Ed) Clinical Medicine Update 2018 (a monograph by Indian Association of Clinical Medicine). 1st edition. Patiala, 2018.

Year : 2011

Concurrent Chemotherapy and Radiation for Carcinoma cervix.

Cite this Research Publication : Jose W, Pavithran K. Concurrent Chemotherapy and Radiation for Carcinoma cervix. In, Rajaram S (Ed). Cervical Cancer: Contemporary Management. 1st edition. New Delhi, Jaypee Brothers Publishers, 2011; Chapter 23.

Scientific reports

Year : 2023

Retrospective observational real-world data on squamous cell carcinoma of the anal canal from South India

Cite this Research Publication : Haridas NK, Jose WP, Rakesh MP. Retrospective observational real-world data on squamous cell carcinoma of the anal canal from South India. Cancer Research, Statistics, and Treatment. 2023 Apr 1;6(2):346-7.

Publisher : Cancer Research, Statistics, and Treatment

Year : 2023

Primary CNS Lymphoma: Neutrophil to Lymphocyte Ratio Predictive of Survival

Cite this Research Publication : Philip A, Jose W, Keechilat P. Primary CNS Lymphoma: Neutrophil to Lymphocyte Ratio Predictive of Survival.https://pesquisa.bvsalud.org/portal/resource/pt/sea-185161.

Publisher : IJAR

Year : 2023

Prospective Evaluation of Response to Treatment, Survival Functions, Recurrence Pattern and Toxicity Profile in Indian Patients with Oligo-Brain Metastasis Treated with Only SRS

Cite this Research Publication : Dutta D, Reddy SK, Kamath RK, Sreenija Y, Nair H, Sashidharan A, Remesan Nair RA, Pushpuja KU, Kannan R, Edappattu A, Haridas NK, Jose WM, Keechilat P. Prospective Evaluation of Response to Treatment, Survival Functions, Recurrence Pattern and Toxicity Profile in Indian Patients with Oligo-Brain Metastasis Treated with Only SRS. Neurol India. 2023 Jan-Feb;71(1):62-71. doi: 10.4103/0028-3886.370470. PMID: 36861576.

Publisher : National Library O f Medicine

Year : 2023

Characterization and Prognostic Significance of Cutaneous Immune-Related Adverse Events in Indian Patients on Immune Checkpoint Inhibitor Therapy

Cite this Research Publication : Duraisamy P, Panicker VV, Jose WM. Characterization and Prognostic Significance of Cutaneous Immune-Related Adverse Events in Indian Patients on Immune Checkpoint Inhibitor Therapy. Dermatol Pract Concept. 2023 Jul 1;13(3):e2023127. doi: 10.5826/dpc.1303a127. PMID: 37557151; PMCID: PMC10412045.

Publisher : National Library of medicine

Year : 2023

The utility of serum amylase as a prognostic marker in multiple myeloma

Cite this Research Publication : Panthula SV, Krishnan S, Jose WM. The utility of serum amylase as a prognostic marker in multiple myeloma. Journal of Cancer Research and Therapeutics. 2023 Apr 4. DOI: 10.4103/jcrt.jcrt_2143_21 (Ahead of Print)

Publisher : National Library of Medicine

Year : 2023

Expression of Her2neu in primary gastric and gastro-esophageal adenocarcinoma – an experience from a tertiary centre in south India.

Cite this Research Publication : Aditi Damle , Roopa Rachel Paulose  , Divya Saikumar , Divya Ail , Niveditha Kartha , Renjitha Bhaskaran , Wesley Jose  , Vidhya Jha ,"Expression of Her2-Neu in Primary Gastric and Gastroesophageal Adenocarcinoma: An Experience from a Tertiary Center in South India",South Asian Journal of Cancer

Publisher : Theime

Year : 2022

A Prospective Study to Evaluate the Efficacy of the Fluorouracil, Leucovorin, Oxaliplatin, and Docetaxel Chemotherapy Regimen in Patients with Locally Advanced and Metastatic Adenocarcinoma of Stomach

Cite this Research Publication : Srinivasalu VK, Philip A, Pillai R, Jose WM, Keechilat P. A Prospective Study to Evaluate the Efficacy of the Fluorouracil, Leucovorin, Oxaliplatin, and Docetaxel Chemotherapy Regimen in Patients with Locally Advanced and Metastatic Adenocarcinoma of Stomach. Indian Journal of Medical and Paediatric Oncology. 2022 Mar 8;43(02):153-8.

Publisher : IJMPO

Year : 2022

Case series of concurrent occurrence of sarcoidosis and breast cancer – A diagnostic dilemma

Cite this Research Publication : Mehta AA, Pavithran K, Jose WM, Vallonthaiel AG, George DR, Sudhakar N. Case series of concurrent occurrence of sarcoidosis and breast cancer - A diagnostic dilemma. Respir Med Case Rep. 2021 Dec 22;35:101565. doi: 10.1016/j.rmcr.2021.101565. PMID: 35004168; PMCID: PMC8717247.

Publisher : National Library of Medicine

Year : 2022

Pretreatment neutrophil-to-lymphocyte ratio predicts lymph node metastasis in triple-negative breast cancer

Cite this Research Publication : Philip A, Jose M, Jose WM, Vijaykumar DK, Pavithran K. Pretreatment neutrophil-to-lymphocyte ratio predicts lymph node metastasis in triple-negative breast cancer. Indian J Cancer. 2022 Oct-Dec;59(4):469-473. doi: 10.4103/ijc.IJC_914_19. PMID: 33753631.

Publisher : National Library of Medicine

Year : 2021

Prognostic significance of immunohistochemical markers in Primary CNS lymphomas

Cite this Research Publication : Phalak P, Rajamma BM, Pradeep A, Retnathankom A, Jose WM, Nair IR. Prognostic significance of immunohistochemical markers in Primary CNS lymphomas. IP Archives of Cytology and Histopathology Research 2021;6(3):160–165

Publisher : IP Archives of Cytology and Histopathology Research Official Publication of Khyati Education and Research Foundation

Year : 2021

Taxanes – The Backbone of Medical Oncology

Cite this Research Publication : Jose WM. Taxanes–The backbone of medical oncology. Indian Journal of Medical and Paediatric Oncology. 2020 Mar;41(02):221-34.

Year : 2021

Triple intrathecal chemotherapy for leptomeningeal carcinomatosis in solid tumors Treatment outcomes, response and their determinants

Cite this Research Publication : Srinivasalu VK, Subramaniam N, Philip A, Jose W, Pavithran K. Triple intrathecal chemotherapy for leptomeningeal carcinomatosis in solid tumors: Treatment outcomes, response and their determinants. Indian J Cancer. 2021 Jan-Mar;58(1):84-90. doi: 10.4103/ijc.IJC_730_18. PMID: 33402572.

Publisher : Indian Journal of Cancer

Year : 2021

A systematic review of clinical and laboratory parameters associated with increased severity among COVID-19 patients

Cite this Research Publication : Mehta AA, Haridas N, Belgundi P, Jose WM. A systematic review of clinical and laboratory parameters associated with increased severity among COVID-19 patients. Diabetes Metab Syndr. 2021 Mar-Apr;15(2):535-541. doi: 10.1016/j.dsx.2021.02.020. Epub 2021 Feb 20. PMID: 33711574; PMCID: PMC7896120.

Publisher : National Library of Medicine

Year : 2020

Assessment of Aromatase Inhibitor-Induced Bone Loss and Appropriateness of Supportive Therapy in Postmenopausal Breast Cancer Patients at a Tertiary Care Center

Cite this Research Publication : Kumari R, James E, Jose WM. Assessment of aromatase inhibitor-induced bone loss and appropriateness of supportive therapy in postmenopausal breast cancer patients at a tertiary care center. Journal of Pharmacology and Pharmacotherapeutics. 2019 Dec;10(4):118-25.

Publisher : Sage Journals Home

Year : 2020

A 66-year-old man with left sided chest pain.

Cite this Research Publication : Mehta AA, Jose WM, Pavithran K. A 66-year-old man with left sided chest pain. Pulmon. 2020 Jan 1;22(1):38-40.

Publisher : Pulmon

Year : 2020

Efficacy of Carica Papaya Leaf Extract in Reducing Treatment-Delay Secondary to Chemotherapy induced Thrombocytopenia

Cite this Research Publication : Sreelatha P, Jose W. Efficacy of Carica Papaya Leaf Extract in Reducing Treatment-Delay Secondary to Chemotherapy induced Thrombocytopenia. Journal of Clinical & Diagnostic Research. 2020 Mar 1;14(3).

Year : 2020

Frequency and Prognosis of Epidermal Growth Factor Receptor Variant III Mutations in Glioblastoma Multiforme among Indian Patients: A Single-Institution Study

Cite this Research Publication : Jose WM, Munirathnam V, Narendranath V, Philip A, Keechilat P. Frequency and Prognosis of Epidermal Growth Factor Receptor Variant III Mutations in Glioblastoma Multiforme among Indian Patients: A Single-Institution Study. South Asian J Cancer. 2020 Jul;9(3):126-129. doi: 10.1055/s-0041-1723078. Epub 2021 Apr 26. PMID: 33937133; PMCID: PMC8075623.

Publisher : National Library of Medicine

Year : 2020

Pathological Complete Response in Locally Advanced Breast Cancer after Neoadjuvant Chemotherapy: Survival Outcome and Its Relevance as a Surrogate End Point

Cite this Research Publication : Agarwal R, Unnikrishnan UG, Keechilat P, Rajanbabu A, Jose W, Vijaykumar DK. Pathological Complete Response in Locally Advanced Breast Cancer after Neoadjuvant Chemotherapy: Survival Outcome and Its Relevance as a Surrogate End Point. South Asian J Cancer. 2020 Jul;9(3):136-140. doi: 10.1055/s-0040-1721238. Epub 2020 Dec 14. PMID: 33937135; PMCID: PMC8075624.

Publisher : NAtional Library of medicine

Year : 2019

Analysis of frequency of alterations in EGFR exon 18-21 in Glioblastoma multiforme and its prognostic significance–A single centre experience from India

Cite this Research Publication : Jose WM, Munirathnam V, Narendranath V, Philip A, Bindhu MR, Keechilat P. Analysis of frequency of alterations in EGFR exon 18-21 in Glioblastoma multiforme and its prognostic significance–A single centre experience from India. IOSR Journal of Pharmacy and Biological Sciences 2019; 14(4): 14-19.

Publisher : Semantic Scholar

Year : 2019

Concurrent chemoradiotherapy for head and neck cancers in older patients: Outcomes and their determinants

Cite this Research Publication : Srinivasalu VK, Subramaniam N, Balasubramanian D, Kumar N, Philip A, Susan A, Pushpaja KU, Nair AR, Thankappan K, Jose W, Iyer S, Keechilat P. Concurrent chemoradiotherapy for head and neck cancers in older patients: Outcomes and their determinants. Indian J Cancer. 2019 Jul-Sep;56(3):261-266. doi: 10.4103/ijc.IJC_725_18. PMID: 31389391.

Publisher : National library of Medicine

Year : 2018

Prolonged remission and good quality of life with maintenance chemotherapy in recurrent ewing’s sarcoma

Cite this Research Publication : Sreelatha P, Jose WM. Prolonged remission and good quality of life with maintenance chemotherapy in recurrent ewing’s sarcoma. J Clin Diagnos Res. 2018 Mar 1;12.

Publisher : Journal of Clinical and Diagnostic Research

Year : 2017

Olanzapine combined with standard antiemetic regimens for prevention of chemotherapy therapy-induced nausea and vomiting: a single-center experience from south India.

Cite this Research Publication : James EM, Drisya PM, Jose WM. Olanzapine combined with standard antiemetic regimens for prevention of chemotherapy therapy‐induced nausea and vomiting: a single‐center experience from South India. Asian J Pharm Clin Res. 2017;10(11):247-51.

Publisher : Asian Journal of Pharmaceutical Clinical Research 2017

Year : 2017

Effect of Lorazepam in Reducing Psychological Distress and Anticipatory Nausea and Vomiting in Patients Undergoing Chemotherapy

Cite this Research Publication : James A, Nair MM, Abraham DS, Kovoor JS, Jose WM, Reghu R. Effect of Lorazepam in Reducing Psychological Distress and Anticipatory Nausea and Vomiting in Patients Undergoing Chemotherapy. J Pharmacol Pharmacother. 2017 Jul-Sep;8(3):112-115. doi: 10.4103/jpp.JPP_54_17. PMID: 29081618; PMCID: PMC5642123.

Publisher : National library of medicine

Year : 2017

Short-course lenalidomide plus low-dose dexamethasone in the treatment of newly diagnosed multiple myeloma-a single-centre pragmatic study

Cite this Research Publication : Jose WM, Pavithran K, Ganesan TS. Short-course lenalidomide plus low-dose dexamethasone in the treatment of newly diagnosed multiple myeloma-a single-centre pragmatic study. Curr Oncol. 2017 Oct;24(5):e361-e367. doi: 10.3747/co.24.3574. Epub 2017 Oct 25. PMID: 29089806; PMCID: PMC5659160.

Publisher : National Library of medicine

Year : 2016

Capox as first line chemotherapy in recurrent and previously untreated metastatic colorectal cancer – an experience from south india

Cite this Research Publication : Majeed A, Palaniappan M, Kumar K, Jose WM, Pavithran K. And Ganesan TS. Cap-Ox as First Line Chemotherapyin Recurrent and Previously Untreated Metastatic Colorectal Cancer - An Experience from South India. International Journal of Recent Scientific Research 2016; 7 (11): 14099-14102

Publisher : Recent Scientific Research

Year : 2014

Hyponatremia: Is there an association with disease profile in head and neck malignancies? Audit from a tertiary cancer care centre

Cite this Research Publication : P. CG, Ravind, R., P Zaheeruddin, M., Jose, W. M., Sheejamol V. S., and Dinesh, M., “Hyponatremia: Is there an association with disease profile in head and neck malignancies? Audit from a tertiary cancer care centre”, Journal of Cancer Research and Therapeutics, vol. 10, 2014.

Publisher : Journal of Cancer Research and Therapeutics

Year : 2014

A case of biphasic pulmonary blastoma showing good response to preoperative chemotherapy

Cite this Research Publication : Muthu P, Unnikrishnan A, Jose WM, Keechilat P. A case of biphasic pulmonary blastoma showing good response to preoperative chemotherapy. Indian J Cancer. 2014 Oct-Dec;51(4):510-1. doi: 10.4103/0019-509X.175297. PMID: 26842180.

Publisher : National Library of Medicine

Year : 2014

Revisiting cutaneous metastasis from carcinoma gall bladder

Cite this Research Publication : Jose WM, Boyella PK, Nair IR, Eapen M, Keechilat P. Revisiting cutaneous metastasis from carcinoma gall bladder. Indian J Dermatol Venereol Leprol. 2014 Jan-Feb;80(1):82-5. doi: 10.4103/0378-6323.125486. PMID: 24448139.

Publisher : IJDVL

Year : 2013

Neoadjuvant Treatment for Carcinoma Bladder

Cite this Research Publication : Jose MW, Pavithran K. Neoadjuvant Treatment for Carcinoma Bladder. Amrita Journal of Medicine 2013; 9 (1): 22-25.

Publisher : Research Gate

Year : 2013

The Role of Gefitinib in Patients with Non-small-cell Lung Cancer in India

Cite this Research Publication : Mehta AA, Jose WM, Pavithran K, Triavadi GS. The Role of Gefitinib in Patients with Non-small-cell Lung Cancer in India. Indian J Palliat Care. 2013 Jan;19(1):48-53. doi: 10.4103/0973-1075.110237. PMID: 23766595; PMCID: PMC3680839.

Publisher : National Library of Medicine

Year : 2012

Malignancies during Pregnancy – A Case Series and a Brief Review of Literature

Cite this Research Publication : Anupama R, Sarah Thomas B, Wesley M, Pavithran K, Vijaykumar DK. Malignancies during Pregnancy–A Case Series and a Brief Review of Literature. Research & Reviews: A Journal of Oncology and Hematology. 2012; 1 (2): 13-20.

Publisher : Research gate

Year : 2011

Hyperesoinophilic syndrome with FIP1L1 PDGFRα mutation: A case study

Cite this Research Publication : Mehta AA, Jose W, Pavithran K. Hyper-esoinophilic Syndrome with FIP1L1 PDGFR alpha Mutation: A Case Study. Journal of Clinical and Diagnostic Research. 2011; 5(3): 625-7.

Publisher : Journal of Clinical and Diagnostic Research

Year : 2011

Aplastic anaemia complicating systemic lupus erythematosus (SLE) at presentation: A clinical vignette and review of literature

Cite this Research Publication : Jose W, Unnikrishnan A, Muthu P, Kumar K, Pavithran K. Aplastic anaemia complicating systemic lupus erythematosus (SLE) at presentation: a clinical vignette and review of the literature. J Clin Diag Res. 2011;5(3):637-9.

Publisher : Journal of Clinical and Diagnostic Research

Year : 2011

Carcinosarcoma of the Pancreas: Report of a Case with a Concise Review of the Literature

Cite this Research Publication : Palaniappan JW, Bindhu S. Carcinosarcoma of the pancreas: report of a case with a concise review of the literature. J Clin Diagn Res. 2011;5:621-4.

Year : 2011

Right hilar mass with hemoptysis: An unusual presentation of uncommon disorder

Cite this Research Publication : Mehta AA, Jose W, Balamugesh, Christopher DJ. Right hilar mass with hemoptysis: An unusual presentation of uncommon disorder. Lung India. 2011 Oct;28(4):306-8. doi: 10.4103/0970-2113.85698. PMID: 22084550; PMCID: PMC3213723.

Publisher : national Library of Medicine

Year : 2010

Autoimmune thrombocytopenic purpura in acute hepatitis A-A report and review of literature

Cite this Research Publication : Jose W, Kumar K, Unnikrishnan A, Palaniappan M, Nair A, Pavithran K. Autoimmune Thrombocytopenic Purpura in Acute Hepatitis AA Report and Review of Literature. Asia Pacific Journal of Oncology & Hematology. 2010 Feb 1;2(1):1.

Publisher : Asia-Pacific Journal of Oncology and Hematology

Year : 2010

Umbilical metastasis: a case series of four Sister Joseph nodules from four different visceral malignancies

Cite this Research Publication : Palaniappan M, Jose WM, Mehta A, Kumar K, Pavithran K. Umbilical metastasis: a case series of four Sister Joseph nodules from four different visceral malignancies. Curr Oncol. 2010 Nov;17(6):78-81. doi: 10.3747/co.v17i6.684. PMID: 21151414; PMCID: PMC2993448.

Publisher : National library of medicine

Year : 2010

Multiple myeloma presenting as eosinophilic pleural effusion

Cite this Research Publication : Mehta AA, Venkatakrishnan R, Jose W, Palaniappan M, Pavithran K. Multiple myeloma presenting as eosinophilic pleural effusion. Asia Pac J Clin Oncol. 2010 Dec;6(4):256-9. doi: 10.1111/j.1743-7563.2010.01324.x. Epub 2010 Sep 29. PMID: 21114774.

Publisher : National library of medicine

Year : 2008

Radial artery occlusion, a rare presentation of Behcet’s disease

Cite this Research Publication : Gera C, Jose W, Malhotra N, Malhotra V, Dhanoa J. Radial artery occlusion, a rare presentation of Behçet's disease. J Assoc Physicians India. 2008 Aug;56:643-4. PMID: 19051714.

Publisher : National Library of medicine

Qualification
  • Medical Training from Christian Medical College and Hospital, Ludhiana, PunjabADDITIONAL TRAINING

Additional training

  • Equator Network – CONSORT 2010 reporting guidelines – Oxford, UK, 2010.
  • Randomized Controlled Trials – Oxford, UK, 2010
  • Statistics for Health Research – Oxford, UK, 2010
Area of Expertise
  • Breast Cancer
  • Brain Tumors (Ault and Pediatric)
  • Gastrointestinal malignancies
  • Multiple Myeloma Lymphoma and Pediatric solid cancers.
Work Experience

Assistant Professor at the Department of Medicine at the Christian Medical College and Hospital, Ludhiana .

Awards and Recognition
  • Fellowship at Indian Academy of Clinical Medicine (IACM)

Memberships of oncology society

  • American Society of Clinical Oncology (ASCO)
  • European Society of Medical Oncology (ESMO)
  • Indian Academy of Cancer Research (IACR)
  • European Association for Cancer Research (EACR)
  • Indian Society of Medical and Pediatric Oncology (ISMPO)
  • Cooperative Trials Group for Neuro-Oncology (COGNO)
  • Indian Society of Neuro-Oncology (ISNO)
  • International CML foundation (iCMLf)
  • Society for Immunotherapy of Cancer (SITC)
  • National Academy of Medical Sciences (NAMS)
  • Association of Physicians of India (API)
  • Indian Academy of Clinical Medicine (IACM)
Responsibility

PRINCIPAL INVESTIGATOR 

  1. D8227C00001: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Acalabrutinib in Combination with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone (R-CHOP) in Subjects ≤65 Years with Previously Untreated Non-Germinal Center Diffuse Large B-Cell Lymphoma (Sponsor: Acerta Pharma B.V.)
  2. D5086C00001: A Phase 3, Open Label, Randomised, 3-arm, Multi-Centre Study of Savolitinib plus Durvalumab Versus Sunitinib and Durvalumab Monotherapy in participants with MET-Driven, Unresectable and Locally Advanced or Metastatic Papillary Renal Cell Carcinoma (PRCC) (SAMETA) (Sponsor: Astra Zeneca)
  3. CA-170-302: A Phase IIb/III, Randomised, Double Blind, Placebo Controlled, Multicentre Study of CA170 in Combination with Chemotherapy in Patients with Stage IV Non-Squamous Non-Small Cell Lung Cancer (ASIAD-3) (Sponsor: Aurigene Discovery Technologies Limited)
  4. ODM-203-201: A Phase II Open-Label Trial Evaluating the Efficacy and Safety of Once Daily Oral ODM-203 in Patients with Unresectable Transitional Cell Urothelial Carcinoma with FGFR3 Mutation (TEJAS-1) (Sponsor: Aurigene Discovery Technologies Limited)
  5. MIT-201702 – A Multicenter Registry Examining the Clinical Utility of CANscriptTM in Routine Clinical Practice. CANSCRIPTTM REGISTRY OF CLINICAL UTILIZATION AND OUTCOME IN CANCER TREATMENTS (CAN-PREDICT)
  6. SB3-G31-BC – A Phase III Randomised, Double-Blind, Parallel Group, Multicentre Study to Compare the Efficacy, Safety, Pharmacokinetics, and Immunogenicity between SB3 (proposed trastuzumab biosimilar) and Herceptin® in Women with Newly Diagnosed HER2 Positive Early or Locally Advanced Breast Cancer in Neoadjuvant Setting. (Sponsor: Samsung)
  7. CBT124/CT/002 – A Randomized, Double-blind, Multicentric, Parallel-group Study Comparing Efficacy, Safety and Immunogenicity of CBT124, a Candidate Biosimilar Bevacizumab in Combination with Carboplatin and Paclitaxel with EU-sourced Avastin® in Combination with Carboplatin and Paclitaxel in First-line Treatment for Subjects with Stage IV (Unresectable Recurrent Disease or Metastatic) Non-squamous Non-Small Cell Lung Cancer (NSCLC). (Sponsor: CIPLA Biotec)
  8. Lenalidomide and Short Course Dexamethasone in Newly Detected Multiple Myeloma – A Single Center Phase 2 Study (Sponsor: NATCO Laboratories)

CO-PRINCIPAL INVESTIGATOR

  1. 19214: A phase IV study to investigate the safety and efficacy of regorafenib in Indian patients with metastatic colorectal cancer (mCRC).
  2. D0816R00025: A Prospective, Multicentre, Phase-IV Clinical Trial of Olaparib in Indian Patients with Platinum Sensitive Relapsed Ovarian Cancer who are in Complete or Partial Response Following Platinum Based Chemotherapy and Metastatic Breast Cancer with Germline BRCA1/2 Mutation.
  3. CBYL719CIN02: Study of PIK3CA mutations and Effectiveness and tolerability outcomes of Alpelisib in Real-world) A descriptive study of PIK3CA mutations and outcomes with Alpelisib in patients with HR-positive and HER2-negative advanced breast cancer (ABC)/ metastatic breast cancer (MBC) in India.
  4. D9102C00001: A Phase II Randomized, Multi-Center, Double-Blind, Global Study to Determine the Efficacy and Safety of Durvalumab plus Olaparib Combination Therapy Compared with Durvalumab Monotherapy as Maintenance Therapy in Patients whose Disease has not Progressed Following Standard of Care Platinum-Based Chemotherapy with Durvalumab in First-Line Stage IV Non-Small Cell Lung Cancer
  5. RI-02-003: Reditux™ Registry to Compare Effectiveness, Safety, and Resource Utilization of Reditux™ vs. the Reference Medicinal Product to Treat Diffuse Large B-Cell Lymphoma (DLBCL) and Chronic Lymphocytic Leukaemia (CLL) in Routine Clinical Practice
  6. LRP/LNP3794/2016/006: A Phase II/III Pivotal, Open label, Randomized, 3 Arm Study to Assess the Efficacy of Lupin’s Molecule Monotherapy or in Combination with Docetaxel, Compared with Docetaxel Alone, in Patients with RAS Mutation Positive Locally Advanced and Metastatic Non-Small Cell Lung Cancer as Second Line Therapy
  7. CLDK378A2301: A phase III multicenter, randomized study of oral LDK378 versus standard chemotherapy in previously untreated adult patients with ALK rearranged (ALK-positive), stage IIIB or IV, non-squamous non-small cell lung cancer.
  8. Protocol No. 476-13: A Prospective, Comparative, Open Label, Randomized, Multicentric, Phase III study to compare the safety and efficacy of Bevacizumab of Intas Pharmaceuticals Limited against Avastin™ in Patients with Unresectable or Metastatic Non-Squamous Non-Small Cell Lung Cancer.
  9. Protocol No. – CDP/03/07: “A randomized, multi-center, open label study to evaluate the efficacy and safety of Peg G-CSF as compared to Grafeel® in the prophylaxis of severe neutropenia in cancer patients receiving cytotoxic chemotherapy”. (Sponsor: Dr. Reddy’s Laboratories).
  10. Protocol No. – MK-0683-088: “An international, Multi-center, Randomized, Double-Blind Study of Vorinostat (MK-0683) or Placebo in Combination with Bortezomib in Patients with Multiple Myeloma”. (Sponsor: Merck & Co Inc.)
  11. Protocol No. – MORAb-003-004: “A Randomized, Double-blind, Placebo-Controlled, Phase 3 Study to Assess the Efficacy and Safety Weekly Farletuzmab (MORAb-003) in Combination with Carboplatin and Taxane in Subjects with Platinum sensitive Ovarian Cancer in First Relapse” (Sponsor: Morphotek Inc.).
  12. Protocol No: EGF 110656: “A Phase III Study of ERBB2 Positive Advanced or Metastatic Gastric or Esophageal or Gastro esophageal Junction Adenocarcinoma Treated With Capecitabine Plus Oxaliplatin With or Without Lapatinib” (Sponsor:GlaxoSmithKline)
  13. Protocol RI-01-002: “A Randomised, Multi-centre, Double-blind, Parallel Group Study to Compare the Pharmacokinetics, Pharmacodynamics, Safety and Efficacy of Two Anti-CD20 Monoclonal Antibodies in Combination with CHOP in Patients with CD20-Positive Diffuse Large B-cell Lymphoma”.
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