Back close

Dr. Bijo Mathew

Professor & HOD, Dept. of Pharmaceutical Chemistry & Analysis, School of Pharmacy, Kochi

Qualification: M. Pharm., Ph.D
bijomathew@pharmacy.aims.amrita.edu
Orcid ID
Scopus Author ID

Bio

Dr. Bijo Mathew is Professor & HOD of Pharmaceutical Chemistry at the Amrita School of Pharmacy, Kochi, India. Dr. Bijo Mathew obtained his M.Pharm in Pharmaceutical Chemistry from The Tamilnadu Dr. M.G.R. Medical University, Tamilnadu, India in 2008 and Ph.D. in Pharmaceutical Sciences from Jawaharlal Nehru Technological University, Hyderabad, India in 2016. Mathew’s primary areas of focus are in drug discovery of neurodegenerative disorders, cancer and molecular modelling. His main research interest is on the design of enzyme inhibitors, and especially MAOs, ChEs and BACE1. He has published 157 papers, [h-index = 31; the number of citations: 2517 in Google scholar; h-index = 31; the number of citations: 2128 in Scopus [August 2021]. With 13 years of teaching and research experience, Mathew authored 1 book, 1 edited book, 5 book chapters and 26 invited talk in national and international level. Dr. B. Mathew is serving as a chief executive guest editor of the journals of Molecules, Current Topics in Medicinal Chemistry, and Current Drug Targets. He is serving in the editorial board of Combinatorial Chemistry and High Throughput Screening. He received Amrita Vishwa Vidyapeetham Chancellor’s Publication Award in 2021. He received one patent from Korean Intellectual Property of Office in the topic of protective or therapeutic compositions of neurological disorders containing furano chalcones as effective agents.

Education

  • 2010-2016: Ph. D. (Pharmaceutical Science)
    Jawaharlal Nehru Technological University, Hyderabad, India.
    Title: Synthesis, Characterisation, and Pharmacological Evaluation of Some Heterocyclic Derivatives under the supervision of Dr. A. Jerad Suresh (Professor & Principal, Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai, India.)
  • 2006-2008: M. Pharm. (Pharmaceutical Chemistry)
    The Tamilnadu Dr. M. G. R. Medical University, Chennai, India.
  • 2001-2005: B. Pharm.
    The Tamilnadu Dr. M. G. R. Medical University, Chennai, India.
  • 1999-2001: Pre-degree
    Mahatma Gandhi University, Kottayam, India.

Area of Interest

  • Chemistry and biological exploration of various class of chalcones.
  • Synthesis of and pharmacological exploration of heterocyclic nucleus such as benzimidazole, thiadiazole, pyrimidine, furan, pyrazoline and thiazole etc.
  • CNS depressant, anticonvulsant, anticancer, antioxidant,antitubercular activity.
  • Design of MAO, Acetylcholinesterase and Hsp90 inhibitors.
  • Microwave assisted synthesis.
  • Structural elucidation of organic molecules by IR, NMR and MASS (mass fragmentation pattern) technique.
  • Molecular docking, Dynamics, Pharmacophore mapping, 3D-QSAR studies.
  • Isolation of natural secondary metabolites from medicinal plant and their insilico studies.

Expert in Drug Design Softwares

  • AutoDock4.2, Molegrow, Arguslab, Hex, LigandScout, Open-Babel, Accelery Discovery, Chem-3D.

Section Editor

  • Coronaviruses [BenthamScience]

Editorial Member

  • Combinatorial Chemistry & High Throughput Screening [BenthamScience]

Chief Executive Guest Editor

  1. Molecules [MDPI] [Impact Factor®:4.4].
    Title of the thematic issue: Recent drug design strategy of the design of molecules against Alzheimer’s disease and Parkinson’s diseases . [Issue under Preparation].
  2. Current Topics in Medicinal Chemistry [Bentham Science] [Impact Factor®:3.3].
    Title of the thematic issue: SAR analysis of various heterocyclic compounds in medicinal chemistry: Recent Updates. [Issue under Preparation].
  3. Current Drug Targets [BenthamScience] [Impact Factor®:2.64].
    Title of the Thematic Issue: Mitochondrial dysfunction and traffic jams in neurodegenerative disorders. [BenthamScience] [Issue under Preparation].
  4. Combinatorial Chemistry & High Throughput Screening [BenthamScience] [Impact Factor®:1.56].
    Title of the Thematic Issue: Inhibitors of Monoamine Oxidase and Acetylcholinesterase as a front runner in CNS drug discovery [Issue under preparation-2020].
  5. Combinatorial Chemistry & High Throughput Screening [BenthamScience] [Impact Factor®:1.56].
    Title of the Thematic Issue: Computational chemistry andsynthetic strategy of the design of novel Monoamine oxidase inhibitors. [2017, 20, 459-578]
  6. Central Nervous System Agents in Medicinal Chemistry [BenthamScience]
    Title of the Thematic Issue: Rational approaches for the design of Monoamine Oxidase Inhibitors [2016, volume 16, Issue 2- Page no: 73-164]

Projects under Supervision

  • B. Pharm. level – 11
  • M. Pharm. level – 1
  • Ph. D.- 4 (ongoing)
Publications

Journal Article

Year : 2021

Replacement of chalcone-ethers with chalcone-thioethers as potent and highly selective monoamine oxidase-b inhibitors and their protein-ligand interactions

Cite this Research Publication : Mathew, B., Oh, J.M., Khames, A., Mathew, G.E., Kim, H. Replacement of chalcone-ethers with chalcone-thioethers as potent and highly selective monoamine oxidase-b inhibitors and their protein-ligand interactions, Pharmaceuticals, 2021, 14(11),1148, DOI: 10.3390/ph14111148

Publisher : Pharmaceuticals

Year : 2021

SAR Analysis of Various Heterocyclic Compounds in Medicinal Chemistry: Recent Updates-Part-I

Cite this Research Publication : Mathew, B., SAR Analysis of Various Heterocyclic Compounds in Medicinal Chemistry: Recent Updates-Part-I, Current Topics in Medicinal Chemistry, 2021, 21(30), pp. 2694, doi: 10.2174/156802662130211210151841.

Publisher : Current Topics in Medicinal Chemistry

Year : 2021

Synthesis of new 1-aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone oxime ether derivatives and investigation of their cytotoxic effects

Cite this Research Publication : Alagöz, M.A., Karakurt, A., Hepokur, C, Kim, H., Mathew, B. Synthesis of new 1-aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone oxime ether derivatives and investigation of their cytotoxic effects, Processes, 2021, 9(11), 2019; https://doi.org/10.3390/pr9112019

Publisher : Processes

Year : 2021

Selected Class of Enamides Bearing Nitro Functionality as Dual-Acting with Highly Selective Monoamine Oxidase-B and BACE1 Inhibitors

Cite this Research Publication : Venkidath, A., Oh, J.M., Dev, S., (...), Kim, H., Mathew, B. Selected class of enamides bearing nitro functionality as dual-acting with highly selective monoamine oxidase-b and bace1 inhibitors, Molecules, Volume 26, Issue 19, 10.3390/molecules26196004

Publisher : Molecules

Year : 2021

An Agathokakological tale of ∆9 -THC: Exploration of Possible Biological Targets.

Cite this Research Publication : Bijo Mathew, Harilal, S., Musa, A., Kumar, R., Parambi, D. Grace Thom, Jose, J., Uddin, M. Sahab, Shah, M. Ajmal, Behl, T., and Unnikrishnan, M. Kesavan, “An Agathokakological tale of ∆9 -THC: Exploration of Possible Biological Targets.”, Current Drug Targets, vol. 22, no. 7, pp. 823 - 834, 2021.

Publisher : Current Drug Targets

Year : 2021

A Comprehensive Overview of Colon Cancer- A Grim Reaper of the 21st Century

Cite this Research Publication : R. Kumar, Harilal, S., Carradori, S., and Bijo Mathew, “A Comprehensive Overview of Colon Cancer- A Grim Reaper of the 21st Century”, Current Medicinal Chemistry, Volume 28, (14), pp. 2657-2696, (2021)

Publisher : Current Medicinal Chemistry

Year : 2021

Revealing the role of fluorine pharmacophore in chalcone scaffold for shifting the MAO-B selectivity: investigation of a detailed molecular dynamics and quantum chemical study.

Cite this Research Publication : F. A. Olotu, Joy, M., Abdelgawad, M. A., Narayanan, S. E., Soliman, M. E., and Bijo Mathew, “Revealing the role of fluorine pharmacophore in chalcone scaffold for shifting the MAO-B selectivity: investigation of a detailed molecular dynamics and quantum chemical study.”, Journal of Biomolecular Structure and Dynamics 2021, 39(16), pp. 6126-6139

Publisher : Journal of Biomolecular Structure and Dynamics

Year : 2021

Development of methylthiosemicarbazones as new reversible monoamine oxidase-B inhibitors for the treatment of Parkinson’s disease.

Cite this Research Publication : G. Elizabeth Mathew, Oh, J. Min, Mohan, K., Tengli, A., Bijo Mathew, and Kim, H., “Development of methylthiosemicarbazones as new reversible monoamine oxidase-B inhibitors for the treatment of Parkinson's disease.”, Journal of Biomolecular Structure and Dynamics, 2021, 39(13), pp. 4786-4794.

Publisher : Journal of Biomolecular Structure and Dynamics

Year : 2021

Navigating into the chemical space of monoamine oxidase inhibitors by artificial intelligence and chemoinformatics approach

Cite this Research Publication : Kumar S, Nair AS, Bhaskar V, Sudevan TS, Vishal PK, Khames A, Abdelgawad MA, and Bijo Mathew, “Navigating into the chemical space of monoamine oxidase inhibitors by artificial intelligence and chemoinformatics approach”, ACS OMEGA [Accepted], 2021.

Publisher : ACS OMEGA

Year : 2021

An Agathokakological tale of ∆9 -THC: Exploration of Possible Biological Targets.

Cite this Research Publication : Bijo Mathew, Harilal, S., Musa, A., Kumar, R., Parambi, D. Grace Thom, Jose, J., Uddin, M. Sahab, Shah, M. Ajmal, Behl, T., and Unnikrishnan, M. Kesavan, “An Agathokakological tale of ∆9 -THC: Exploration of Possible Biological Targets.”, Current Drug Targets, vol. 22, no. 7, pp. 823 - 834, 2021.

Publisher : Current Drug Targets

Year : 2021

Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations.

Cite this Research Publication : R. Sasidharan, Eom, B. Hyun, Heo, J. Hyun, Park, J. Eun, Abdelgawad, M. A., Musa, A., Gambacorta, N., Nicolotti, O., Manju, S. Leelabaiam, Bijo Mathew, and Kim, H., “Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations.”, Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 36, no. 1, pp. 188-197, 2021.

Publisher : Journal of Enzyme Inhibition and Medicinal Chemistry

Year : 2021

Recent updates on pyrazolines derivatives as promising candidates for neuropsychiartic and neurodegenerative disorders

Cite this Research Publication : Rangarajan TM and Bijo Mathew, “Recent updates on pyrazolines derivatives as promising candidates for neuropsychiartic and neurodegenerative disorders”, Current Topics in Medicinal Chemistry, 2021;21(30):2695-2714, DOI: 10.2174/1568026621999210902123132

Publisher : Current Topics in Medicinal Chemistry

Year : 2021

COVID-19 and domestic animals: Exploring the species barrier crossing, zoonotic and reverse zoonotic transmission of SARS-CoV-2.

Cite this Research Publication : R. Kumar, Harilal, S., Al-Sehemi, A. G., Paninipara, M., Behl, T., Mathew, G. Elizabeth, and Bijo Mathew, “COVID-19 and domestic animals: Exploring the species barrier crossing, zoonotic and reverse zoonotic transmission of SARS-CoV-2.”, Current Pharmaceutical Design, Volume 27, Issue 9, pp. 1194-1201, (2021)

Publisher : Curr Pharm Des

Year : 2021

Ameliorative effect of ethoxylated chalcone based MAO-B inhibitor on behavioural predictors of Haloperidol-induced Parkinsonism in mice: Evidence of its anti-oxidative role against Parkinson’s diseases

Cite this Research Publication : Maliyakkal N, Saleem U, Anwar F, Shah FA, Ahmad B, Umer F, Almoyad MAA, DGT, P., Beeran AP, Nath LR, Aleya L, and Bijo Mathew, “Ameliorative effect of ethoxylated chalcone based MAO-B inhibitor on behavioural predictors of Haloperidol-induced Parkinsonism in mice: Evidence of its anti-oxidative role against Parkinson’s diseases”, Environmental Science and Pollution Research. [Accepted], 2021.

Publisher : Environmental Science and Pollution Research

Year : 2021

Dysregulation of the Gut-Brain Axis, Dysbiosis and Influence of Numerous Factors on Gut Microbiota Associated Parkinson’s Disease

Cite this Research Publication : G. Kaur, Behl, T., Bungau, S., Kumar, A., Uddin, M. Sahab, Mehta, V., Zengin, G., Bijo Mathew, Shah, M. Ajmal, and Arora, S., “Dysregulation of the Gut-Brain Axis, Dysbiosis and Influence of Numerous Factors on Gut Microbiota Associated Parkinson's Disease.”, Curr Neuropharmacol, vol. 19, no. 2, pp. 233-247, 2021.

Publisher : Curr Neuropharmacol

Year : 2021

The Chronicle of COVID-19 and Possible Strategies to Curb the Pandemic

Cite this Research Publication : R. Kumar, Harilal, S., Al-Sehemi, A. G., Mathew, G. Elizabeth, Carradori, S., and Bijo Mathew, “The Chronicle of COVID-19 and Possible Strategies to Curb the Pandemic”, Current Medicinal Chemistry, 2021, 28(15), pp. 2852-2886

Publisher : Curr Med Chem,

Year : 2021

Insights into an Immunotherapeutic Approach to Combat Multidrug Resistance in Hepatocellular Carcinoma

Cite this Research Publication : Devan AR, Kumar AR, Nair B, Anto NP, Muraleedharan A, Bijo Mathew, Kim H, and Nath LR, “Insights into an Immunotherapeutic Approach to Combat Multidrug Resistance in Hepatocellular Carcinoma”, Pharmaceuticals, vol. 14, no. 7, p. 656, 2021.

Publisher : Pharmaceuticals

Year : 2021

Current Progress in Quinazoline Derivatives as Acetylcholinesterase and Monoamine Oxidase Inhibitors

Cite this Research Publication : N. Abdul Rehuman, Al-Sehemi, A. G., Parambi, D. Grace Thom, Rangarajan, T. M., Nicolotti, O., Kim, H., and Bijo Mathew, “Current Progress in Quinazoline Derivatives as Acetylcholinesterase and Monoamine Oxidase Inhibitors”, ChemistrySelect, vol. 6, no. 28, pp. 7162-7182, 2021. DOI: https://doi.org/10.1002/slct.202101077

Publisher : ChemistrySelect

Year : 2021

New Aspects of Monoamine Oxidase B Inhibitors: The Key Role of Halogens to Open the Golden Door.

Cite this Research Publication : Bijo Mathew, Carradori, S., Guglielmi, P., Uddin, M. Sahab, and Kim, H., “New Aspects of Monoamine Oxidase B Inhibitors: The Key Role of Halogens to Open the Golden Door.”, Current Medicinal Chemistry, 2021, 28(2), pp. 266-283

Publisher : Current Medicinal Chemistry

Year : 2021

Deciphering the detailed structure – activity relationship of coumarins as Monoamine oxidase enzyme inhibitors – An updated review.

Cite this Research Publication : V. Payyalot Koyiparambath, Pr, K., RangarajanT, M., Al-Sehemi, A., Pannipara, M., Bhaskar, V., Nair, A. Sujathan, Sudevan, S. Thazhathuv, Kumar, S., and Bijo Mathew, “Deciphering the detailed structure-activity relationship of coumarins as Monoamine oxidase enzyme inhibitors-An updated review.”, Chemical Biology and Drug Design, Wiley-VCH (2021), 98(4), pp. 655-673

Publisher : Wiley-VCH

Year : 2021

Synthesis of N ′-(4-/3-/2-/Non-substituted benzylidene)-4-[(4-methylphenyl)sulfonyloxy] Benzohydrazides and Evaluation of Their Inhibitory Activities against Monoamine Oxidases and β-Secretase.

Cite this Research Publication : H. Erdinç Sellitepe, Oh, J. Min, Doğan, İ. Selin, Yildirim, S., Aksel, A. Buğra, Jeong, G. Seok, Khames, A., Abdelgawad, M. A., Gambacorta, N., Nicolotti, O., Bijo Mathew, and Kim, H., “Synthesis of N ′-(4-/3-/2-/Non-substituted benzylidene)-4-[(4-methylphenyl)sulfonyloxy] Benzohydrazides and Evaluation of Their Inhibitory Activities against Monoamine Oxidases and β-Secretase.”, Applied Sciences (2076-3417) , vol. 11, no. 13, pp. 5830-5830, 2021.

Publisher : Applied Sciences

Year : 2021

Current perspective of COVID-19 on neurology: A mechanistic insight.

Cite this Research Publication : R. Kumar, Harilal, S., Pappachan, L. K., and Bijo Mathew, “Current perspective of COVID-19 on neurology: A mechanistic insight.”, Combinatorial Chemistry and High Throughput Screening (Accepted), 2021.

Publisher : Bentham Science

Year : 2021

Development of 2D, 3D-QSAR and pharmacophore modeling of chalcones for the inhibition of monoamine oxidase B.

Cite this Research Publication : Bijo Mathew, Acevedo, C. H., Sc, D., Rangarajan TM, MS, K., NP, N. Punnoth Po, L, S., and MT., S., “Development of 2D, 3D-QSAR and pharmacophore modeling of chalcones for the inhibition of monoamine oxidase B. ”, Combinatorial Chemistry and High Throughput Screening. (Accepted), 2021.

Publisher : Combinatorial Chemistry and High Throughput Screening

Year : 2021

Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders.

Cite this Research Publication : P. Koyiparamb Vishal, Oh, J. Min, Khames, A., Abdelgawad, M. A., Nair, A. Sujathan, Nath, L. R., Gambacorta, N., Ciriaco, F., Nicolotti, O., Kim, H., and Bijo Mathew, “Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders.”, Pharmaceutics, vol. 13, no. 6, 2021.

Publisher : Pharmaceutics

Year : 2021

Targeting cellular batteries for the therapy of neurological diseases

Cite this Research Publication : A. Arora, Behl, T., Sehgal, A., Singh, S., Sharma, N., Bijo Mathew, and Bungau, S., “Targeting cellular batteries for the therapy of neurological diseases”, vol. 28, no. 31, pp. 41517 - 41532, 2021.

Publisher : Springer Nature

Year : 2021

Trimethoxy Crown Chalcones as Multifunctional Class of Monoamine Oxidase Enzyme Inhibitors.

Cite this Research Publication : N. Maliyakkal, Baysal, I., Tengli, A., Ucar, G., Almoyad, M. Ali Abdull, Parambi, D. Grace Thom, Gambacorta, N., Nicolotti, O., Beeran, A. Appadath, and Bijo Mathew, “Trimethoxy Crown Chalcones as Multifunctional Class of Monoamine Oxidase Enzyme Inhibitors.”, Combinatorial Chemistry and High Throughput Screening, 2021.

Publisher : Bentham Science

Year : 2021

An Update of Synthetic Approaches and Structure-Activity Relationships of Various Classes of Human MAO-B Inhibitors

Cite this Research Publication : P. Sharma, Singh, D. Manjinder, and Bijo Mathew, “An Update of Synthetic Approaches and Structure-Activity Relationships of Various Classes of Human MAO-B Inhibitors”, ChemistrySelect, vol. 6, no. 7, pp. 1404-1429, 2021.

Publisher : ChemistrySelect

Year : 2021

Synthesis, Cytotoxicity and Anti-Proliferative Activity Against AGS Cells of New 3(2)-Pyridazinone Derivatives Endowed with a Piperazinyl Linker.

Cite this Research Publication : M. Abdullah Alagöz, Özdemir, Z., Uysal, M., Carradori, S., Gallorini, M., Ricci, A., Zara, S., and Bijo Mathew, “Synthesis, Cytotoxicity and Anti-Proliferative Activity Against AGS Cells of New 3(2)-Pyridazinone Derivatives Endowed with a Piperazinyl Linker.”, Pharmaceuticals (Basel), Volume 14, Issue 3, 183, pp. 1-27 (2021)

Publisher : Basel

Year : 2021

Neuroprotective Effects of Ellagic Acid in Alzheimer’s Disease: Focus on Underlying Molecular Mechanisms of Therapeutic Potential.

Cite this Research Publication : N. Javaid, Shah, M. Ajmal, Rasul, A., Chauhdary, Z., Saleem, U., Khan, H., Ahmed, N., Uddin, M. Sahab, Bijo Mathew, Behl, T., and Blundell, R., “Neuroprotective Effects of Ellagic Acid in Alzheimer's Disease: Focus on Underlying Molecular Mechanisms of Therapeutic Potential.”, Current Pharmaceutical Design, Bentham Science Publishers, 2021, 27(34), pp. 3591-3601

Publisher : Bentham Science Publishers

Year : 2021

Development of Halogenated Pyrazolines as Selective Monoamine Oxidase-B Inhibitors: Deciphering via Molecular Dynamics Approach.

Cite this Research Publication : A. Sujathan Nair, Oh, J. - M., Koyiparambath, V. Payyalot, Sunil Kumar, Sudevan, S. Thazhathuv, Soremekun, O., Soliman, M. E., Khames, A., Abdelgawad, M. A., Pappachen, L. K., Bijo Mathew, and Kim, H., “Development of Halogenated Pyrazolines as Selective Monoamine Oxidase-B Inhibitors: Deciphering via Molecular Dynamics Approach.”, Molecules, vol. 26, no. 11, 2021.

Publisher : Molecules

Year : 2021

Nanotechnology-Based Approaches and Investigational Therapeutics against COVID-19.

Cite this Research Publication : M. Mominur Rahman, Ahmed, M., Islam, M. Touhidul, Khan, M. Robin, Sultana, S., Maeesa, S. Kabir, Hasan, S., Hossain, M. Abid, Ferdous, K. Sayma, Bijo Mathew, Rauf, A., and Uddin, M. Sahab, “Nanotechnology-Based Approaches and Investigational Therapeutics against COVID-19.”, Current Pharmaceutical Design, 2021.

Publisher : Current Pharmaceutical Design

Year : 2021

Therapeutic Potential of Polyphenols in the Management of Diabetic Neuropathy.

Cite this Research Publication : M. Tanvir Kabir, Tabassum, N., Uddin, M. Sahab, Aziz, F., Behl, T., Bijo Mathew, Rahman, M. Habibur, Akter, R., Rauf, A., and Aleya, L., “Therapeutic Potential of Polyphenols in the Management of Diabetic Neuropathy.”, Evidence based Complementary and Alternative Medicine, vol. 2021, p. 9940169, 2021.

Publisher : Evidence based Complementary and Alternative Medicine

Year : 2021

Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders

Cite this Research Publication : Bijo Mathew, Oh, J. Min, Baty, R. S., Batiha, G. El- Saber, Parambi, D. Grace Thom, Gambacorta, N., Nicolotti, O., and Kim, H., “Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders”, Environmental Science and Pollution Research, 2021, 28(29), pp. 38855-38866.

Publisher : Environmental Science and Pollution Research

Year : 2021

Lysophosphatidic acid (LPA) receptor modulators: Structural features and recent development.

Cite this Research Publication : B. Meduri, Pujar, G. Veeranna, T Kumar, D. Ananda, Akshatha, H. S., Sethu, A. Kumar, Singh, M., Kanagarla, A., and Bijo Mathew, “Lysophosphatidic acid (LPA) receptor modulators: Structural features and recent development.”, Eur J Med Chem, vol. 222, p. 113574, 2021.

Publisher : ELSEVIER

Year : 2020

Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors

Cite this Research Publication : M. Çeçen, Oh, J. Min, Özdemir, Z., Büyüktuncel, S. Ebru, Uysal, M., Abdelgawad, M. A., Musa, A., Gambacorta, N., Nicolotti, O., Mathew, B., and Kim, H., “Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors.”, Molecules, vol. 25, no. 22, p. 5371, 2020.

Publisher : Molecules, Volume 25, Issue 22

Year : 2020

Exploring the Therapeutic Potentials of Highly Selective Oxygenated Chalcone Based MAO-B Inhibitors in a Haloperidol-Induced Murine Model of Parkinson’s Disease

Cite this Research Publication : D. Grace Thom Parambi, Saleem, U., Shah, M. Ajmal, Anwar, F., Ahmad, B., Manzar, A., Itzaz, A., Harilal, S., Uddin, M. Sahab, Kim, H., and Bijo Mathew, “Exploring the Therapeutic Potentials of Highly Selective Oxygenated Chalcone Based MAO-B Inhibitors in a Haloperidol-Induced Murine Model of Parkinson’s Disease”, Neurochemical Research, vol. 45, no. 11, pp. 2786 - 2799, 2020.

Publisher : Neurochemical Research

Year : 2020

A New Potent and Selective Monoamine Oxidase-B Inhibitor with Extended Conjugation in a Chalcone Framework: 1-[4-(Morpholin-4-yl)phenyl]-5-phenylpenta-2,4-dien-1-one.

Cite this Research Publication : N. Maliyakkal, Eom, B. Hyun, Heo, J. Hyun, Almoyad, M. Ali Abdull, Parambi, D. Grace Thom, Gambacorta, N., Nicolotti, O., Beeran, A. Appadath, Kim, H., and Bijo Mathew, “A New Potent and Selective Monoamine Oxidase-B Inhibitor with Extended Conjugation in a Chalcone Framework: 1-[4-(Morpholin-4-yl)phenyl]-5-phenylpenta-2,4-dien-1-one.”, ChemMedChem, vol. 15, no. 17, pp. 1629-1633, 2020.

Publisher : ChemMedChem

Year : 2020

(Hetero-)(arylidene)arylhydrazides as Multitarget-Directed Monoamine Oxidase Inhibitors

Cite this Research Publication : A. Palakkathondi, Oh, J. Min, Dev, S., Rangarajan, T. M., Kaipakasseri, S., Kavully, F. Sahla, Gambacorta, N., Nicolotti, O., Kim, H., and Bijo Mathew, “(Hetero-)(arylidene)arylhydrazides as Multitarget-Directed Monoamine Oxidase Inhibitors”, ACS Combinatorial ScienceACS Combinatorial Science, vol. 22, no. 11, pp. 592 - 599, 2020.

Publisher : American Chemical Society

Year : 2020

Natural Products Database Screening for the Discovery of Naturally Occurring SARS-Cov-2 Spike Glycoprotein Blockers

Cite this Research Publication : A. G. Al-Sehemi, Olotu, F. A., Dev, S., Pannipara, M., Soliman, M. E., Carradori, S., and Bijo Mathew, “Natural Products Database Screening for the Discovery of Naturally Occurring SARS-Cov-2 Spike Glycoprotein Blockers”, ChemistrySelect, vol. 5, pp. 13309-13317, 2020.

Publisher : ChemistrySelect

Year : 2020

Revisiting the role of brain and peripheral Aβ in the pathogenesis of Alzheimer’s disease

Cite this Research Publication : M. Sahab Uddin, Kabir, M. Tanvir, Tewari, D., Mamun, A. Al, Bijo Mathew, Aleya, L., Barreto, G. E., Bin-Jumah, M. N., Abdel-Daim, M. M., and Ashraf, G. Md, “Revisiting the role of brain and peripheral Aβ in the pathogenesis of Alzheimer's disease”, Journal of the Neurological Sciences, vol. 416, p. 116974, 2020.

Publisher : Journal of the Neurological Sciences

Year : 2020

Molecular mechanism of zinc neurotoxicity in Alzheimer’s disease

Cite this Research Publication : S. Ellickal Narayanan, Rehuman, N. Abdul, Harilal, S., Vincent, A., Rajamma, R. Ganesan, Behl, T., Uddin, M. Sahab, Ashraf, G. Md, and Bijo Mathew, “Molecular mechanism of zinc neurotoxicity in Alzheimer’s disease”, Environ Sci Pollut Res, vol. 27, no. 35, pp. 43542 - 43552, 2020.

Publisher : Environ Sci Pollut Res

Year : 2020

Natural compounds from Leeamacrophyllaenhance phagocytosis and promote osteoblastsdifferentiationbyAlp, Type 1 collagen and Osteocalcin gene expression.

Cite this Research Publication : S. Raiyan, Rahman, A., Mamun, A. Al, Asim, M. Haque, Makki, A., Hajjar, D., Alelwani, W., Tangpong, J., and Bijo Mathew, “Natural compounds from Leeamacrophyllaenhance phagocytosis and promote osteoblastsdifferentiationbyAlp, Type 1 collagen and Osteocalcin gene expression.”, Journal of Biomedical Materials Research Part A, 2020.

Publisher : Journal of Biomedical Materials Research Part A

Year : 2020

Selected 1,3-Benzodioxine-Containing Chalcones as Multipotent Oxidase and Acetylcholinesterase Inhibitors.

Cite this Research Publication : G. Seok Jeong, Kaipakasseri, S., Lee, S. Ryong, Marraiki, N., Batiha, G. El- Saber, Dev, S., Palakkathondi, A., Kavully, F. Sahla, Gambacorta, N., Nicolotti, O., Bijo Mathew, and Kim, H., “Selected 1,3-Benzodioxine-Containing Chalcones as Multipotent Oxidase and Acetylcholinesterase Inhibitors.”, ChemMedChem, vol. 15, pp. 2257-2263, 2020.

Publisher : ChemMedChem

Year : 2020

Synthesis and biological evaluation of new 3(2)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells.

Cite this Research Publication : Z. Özdemir, Utku, S., Bijo Mathew, Carradori, S., Orlando, G., Di Simone, S., Alagöz, M. Abdullah, Özçelik, A. Berna, Uysal, M., and Ferrante, C., “Synthesis and biological evaluation of new 3(2)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells.”, J Enzyme Inhib Med Chem, vol. 35, no. 1, pp. 1100-1109, 2020.

Publisher : J Enzyme Inhib Med Chem

Year : 2020

Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors

Cite this Research Publication : P. Guglielmi, Bijo Mathew, Secci, D., and Carradori, S., “Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors”, European Journal of Medicinal Chemistry, vol. 205, p. 112650, 2020.

Publisher : European Journal of Medicinal Chemistry

Year : 2020

Design of enamides as new selective monoamine oxidase-B inhibitors

Cite this Research Publication : F. Sahla Kavully, Oh, J. Min, Dev, S., Kaipakasseri, S., Palakkathondi, A., Vengamthodi, A., Azeez, R. Fathima Ab, Tondo, A. Rita, Nicolotti, O., Kim, H., and Bijo Mathew, “Design of enamides as new selective monoamine oxidase-B inhibitors”, Journal of Pharmacy and Pharmacology, vol. 72, pp. 916-926, 2020.

Publisher : Journal of Pharmacy and Pharmacology

Year : 2020

Privileged Pharmacophore of FDA Approved Drugs in Combination with Chalcone Framework: A New Hope for Alzheimer’s Treatment.

Cite this Research Publication : Bijo Mathew, “Privileged Pharmacophore of FDA Approved Drugs in Combination with Chalcone Framework: A New Hope for Alzheimer's Treatment.”, Comb Chem High Throughput Screen, vol. 23, no. 9, pp. 842-846, 2020.

Publisher : Comb Chem High Throughput Screen

Year : 2020

Molecular Insight into the Therapeutic Promise of Targeting for Alzheimer’s Disease.

Cite this Research Publication : A. Al Mamun, Uddin, M. Sahab, Bin Bashar, M. Fahim, Zaman, S., Begum, Y., Bulbul, I. Jahan, Islam, M. Siddiqul, Sarwar, M. Shahid, Bijo Mathew, Amran, M. Shah, Ashraf, G. Md, Bin-Jumah, M. N., Mousa, S. A., and Abdel-Daim, M. M., “Molecular Insight into the Therapeutic Promise of Targeting for Alzheimer's Disease.”, Oxid Med Cell Longev, vol. 2020, p. 5086250, 2020.

Publisher : Oxid Med Cell Longev

Year : 2020

Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors.

Cite this Research Publication : J. Min Oh, Rangarajan, T. M., Chaudhary, R., Singh, R. Pal, Singh, M., Singh, R. Pal, Tondo, A. Rita, Gambacorta, N., Nicolotti, O., Bijo Mathew, and Kim, H., “Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors.”, Molecules, vol. 25, no. 10, 2020.

Publisher : Molecules

Year : 2020

Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer’s disease

Cite this Research Publication : M. Sahab Uddin, Rahman, M. Ataur, Kabir, M. Tanvir, Behl, T., Bijo Mathew, Perveen, A., Barreto, G. E., Bin-Jumah, M. N., Abdel-Daim, M. M., and Ashraf, G. Md, “Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease.”, IUBMB Life, vol. 72, no. 9, pp. 1843-1855, 2020.

Publisher : IUBMB Life

Year : 2020

Emerging Promise of Immunotherapy for Alzheimer’s Disease: A New Hope for the Development of Alzheimer’s Vaccine.

Cite this Research Publication : M. Tanvir Kabir, Uddin, M. Sahab, Bijo Mathew, Das, P. Kumar, Perveen, A., and Ashraf, G. Md, “Emerging Promise of Immunotherapy for Alzheimer's Disease: A New Hope for the Development of Alzheimer's Vaccine.”, Curr Top Med Chem, vol. 20, no. 13, pp. 1214-1234, 2020.

Publisher : Curr Top Med Chem

Year : 2020

Combination Drug Therapy for the Management of Alzheimer’s Disease.

Cite this Research Publication : M. Tanvir Kabir, Uddin, M. Sahab, Mamun, A. Al, Jeandet, P., Aleya, L., Mansouri, R. A., Ashraf, G. Md, Bijo Mathew, Bin-Jumah, M. N., and Abdel-Daim, M. M., “Combination Drug Therapy for the Management of Alzheimer's Disease.”, Int J Mol Sci, vol. 21, no. 9, 2020.

Publisher : Int J Mol Sci

Year : 2020

Fascinating chemo preventive story of wogonin: A chance to hit on the head in cancer treatment.

Cite this Research Publication : R. Kumar, Harilal, S., Parambi, D. Grace Thom, Narayanan, S. E., Uddin, M. Sahab, Marathakam, A., Jose, J., Mathew, G. Elizabeth, and Bijo Mathew, “Fascinating chemo preventive story of wogonin: A chance to hit on the head in cancer treatment.”, Curr Pharm Des, 2020.

Publisher : Curr Pharm Des

Year : 2020

Novel Anti-Alzheimer’s Therapeutic Molecules Targeting Amyloid Precursor Protein Processing.

Cite this Research Publication : M. Sahab Uddin, Kabir, M. Tanvir, Jeandet, P., Bijo Mathew, Ashraf, G. Md, Perveen, A., Bin-Jumah, M. N., Mousa, S. A., and Abdel-Daim, M. M., “Novel Anti-Alzheimer's Therapeutic Molecules Targeting Amyloid Precursor Protein Processing.”, Oxid Med Cell Longev, vol. 2020, p. 7039138, 2020.

Publisher : Oxid Med Cell Longev

Year : 2020

Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules

Cite this Research Publication : S. Harilal, Jose, J., Parambi, D. Grace Thom, Kumar, R., Unnikrishnan, M. Kesavan, Uddin, M. Sahab, Mathew, G. Elizabeth, Pratap, R., Marathakam, A., and Bijo Mathew, “Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules”, Brain Research Bulletin, vol. 160, pp. 121-140, 2020.

Publisher : Brain Research Bulletin

Year : 2020

A Comprehensive Review of Monoamine Oxidase-A Inhibitors in their Syntheses and Potencies.

Cite this Research Publication : N. A. Rehuman, Bijo Mathew, Jat, R. K., Nicolotti, O., and Kim, H., “A Comprehensive Review of Monoamine Oxidase-A Inhibitors in their Syntheses and Potencies.”, Comb Chem High Throughput Screen, vol. 23, no. 9, pp. 898-914, 2020.

Publisher : Comb Chem High Throughput Screen

Year : 2020

Inhibitions of monoamine oxidases and acetylcholinesterase by 1-methyl, 5-phenyl substituted thiosemicarbazones: Synthesis, biochemical, and computational investigations

Cite this Research Publication : G. Elizabeth Mathew, Oh, J. Min, Mohan, K., Kumudhavalli, M. V., Jayanthi, S., Kim, H., and Bijo Mathew, “Inhibitions of monoamine oxidases and acetylcholinesterase by 1-methyl, 5-phenyl substituted thiosemicarbazones: Synthesis, biochemical, and computational investigations”, Process Biochemistry, vol. 99, pp. 246-253, 2020.

Publisher : Process Biochemistry

Year : 2020

TV 3326 for Alzheimer’s dementia: a novel multimodal ChE and MAO inhibitors to mitigate Alzheimer’s-like neuropathology

Cite this Research Publication : M. Sahab Uddin, Kabir, M. Tanvir, Rahman, M. Motiar, Bijo Mathew, Shah, M. Ajmal, and Ashraf, G. Md, “TV 3326 for Alzheimer’s dementia: a novel multimodal ChE and MAO inhibitors to mitigate Alzheimer’s-like neuropathology”, Journal of Pharmacy and Pharmacology, vol. 72, pp. 1001-1012, 2020.

Publisher : Journal of Pharmacy and Pharmacology

Year : 2020

Estrogen Signaling in Alzheimer’s Disease: Molecular Insights and Therapeutic Targets for Alzheimer’s Dementia.

Cite this Research Publication : M. Sahab Uddin, Rahman, M. Motiar, Jakaria, M., Rahman, M. Sohanur, Hossain, M. Sarwar, Islam, A., Ahmed, M., Bijo Mathew, Omar, U. Mohammed, Barreto, G. E., and Ashraf, G. Md, “Estrogen Signaling in Alzheimer's Disease: Molecular Insights and Therapeutic Targets for Alzheimer's Dementia.”, Mol Neurobiol, vol. 57, no. 6, pp. 2654-2670, 2020.

Publisher : Mol Neurobiol

Year : 2020

Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer’s Disease.

Cite this Research Publication : S. Ellickal Narayanan, Sekhar, N., Rajamma, R. Ganesan, Marathakam, A., Mamun, A. Al, Uddin, M. Sahab, and Bijo Mathew, “Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer's Disease.”, Curr Protein Pept Sci, vol. 21, no. 12, pp. 1164-1173, 2020.

Publisher : Curr Protein Pept Sci

Year : 2020

Exploring the Promise of Targeting Ubiquitin-Proteasome System to Combat Alzheimer’s Disease.

Cite this Research Publication : A. Al Mamun, Uddin, M. Sahab, Kabir, M. Tanvir, Khanum, S., Sarwar, M. Shahid, Bijo Mathew, Rauf, A., Ahmed, M., and Ashraf, G. Md, “Exploring the Promise of Targeting Ubiquitin-Proteasome System to Combat Alzheimer's Disease.”, Neurotox Res, vol. 38, no. 1, pp. 8-17, 2020.

Publisher : Neurotox Res

Year : 2020

Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease.

Cite this Research Publication : M. Sahab Uddin, Kabir, M. Tanvir, Niaz, K., Jeandet, P., Clément, C., Bijo Mathew, Rauf, A., Rengasamy, K. R. R., Sobarzo-Sánchez, E., Ashraf, G. Md, and Aleya, L., “Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer's Disease.”, Molecules, vol. 25, no. 6, 2020.

Publisher : Molecules

Year : 2020

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety.

Cite this Research Publication : M. M. Al-Sanea, Gotina, L., Mohamed, M. Fa, Parambi, D. Grace Thom, Gomaa, H. A. M., Bijo Mathew, Youssif, B. G. M., Alharbi, K. Saad, Elsayed, Z. M., Abdelgawad, M. A., and Eldehna, W. M., “Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety.”, Drug Des Devel Ther, vol. 14, pp. 497-508, 2020.

Publisher : Drug Des Devel Ther

Year : 2020

Exploring the Multifunctional Neuroprotective Promise of Rasagiline Derivatives for Multi-Dysfunctional Alzheimer’s Disease.

Cite this Research Publication : M. Sahab Uddin, Kabir, M. Tanvir, Rahman, M. Habibur, Alim, M. Abdul, Rahman, M. Motiar, Khatkar, A., Mamun, A. Al, Rauf, A., Bijo Mathew, and Ashraf, G. Md, “Exploring the Multifunctional Neuroprotective Promise of Rasagiline Derivatives for Multi-Dysfunctional Alzheimer's Disease.”, Curr Pharm Des, vol. 26, no. 37, pp. 4690-4698, 2020.

Publisher : Curr Pharm Des

Year : 2020

Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders.

Cite this Research Publication : M. Sahab Uddin, Mamun, A. Al, Jakaria, M., Thangapandiyan, S., Ahmad, J., Rahman, M. Ataur, Bijo Mathew, Abdel-Daim, M. M., and Aleya, L., “Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders.”, Sci Total Environ, vol. 707, p. 135624, 2020.

Publisher : Sci Total Environ

Year : 2020

Nanoparticles and its biomedical applications in health and diseases: special focus on drug delivery.

Cite this Research Publication : N. Zahin, Anwar, R., Tewari, D., Kabir, M. Tanvir, Sajid, A., Bijo Mathew, Uddin, M. Sahab, Aleya, L., and Abdel-Daim, M. M., “Nanoparticles and its biomedical applications in health and diseases: special focus on drug delivery.”, Environ Sci Pollut Res Int, vol. 27, no. 16, pp. 19151-19168, 2020.

Publisher : Environ Sci Pollut Res Int

Year : 2020

Studies on the interaction between HSA and new halogenated metformin derivatives: influence of lipophilic groups in the binding ability.

Cite this Research Publication : O. Augusto Chaves, Bijo Mathew, Parambi, D. Grace Thom, de Oliveira, C. Henrique C., Cesarin-Sobrinho, D., Lakshminarayanan, B., Najeeb, S., Nafna, E. K., Marathakam, A., Uddin, M. Sahab, Joy, M., and Netto-Ferreira, J. Carlos, “Studies on the interaction between HSA and new halogenated metformin derivatives: influence of lipophilic groups in the binding ability.”, J Biomol Struct Dyn, vol. 38, no. 7, pp. 2128-2140, 2020.

Publisher : J Biomol Struct Dyn

Year : 2020

Toxic tau: structural origins of tau aggregation in Alzheimer’s disease.

Cite this Research Publication : A. Al Mamun, Uddin, M. Sahab, Bijo Mathew, and Ashraf, G. Md, “Toxic tau: structural origins of tau aggregation in Alzheimer's disease.”, Neural Regen Res, vol. 15, no. 8, pp. 1417-1420, 2020.

Publisher : Neural Regen Res

Year : 2020

Emerging signal regulating potential of small molecule biflavonoids to combat neuropathological insults of Alzheimer’s disease.

Cite this Research Publication : M. Sahab Uddin, Kabir, M. Tanvir, Tewari, D., Bijo Mathew, and Aleya, L., “Emerging signal regulating potential of small molecule biflavonoids to combat neuropathological insults of Alzheimer's disease.”, Sci Total Environ, vol. 700, p. 134836, 2020.

Publisher : Sci Total Environ

Year : 2020

Inhibitors of Monoamine Oxidase and Acetylcholinesterase as a Front Runner in CNS Drug Discovery

Cite this Research Publication : Bijo Mathew and Kim, H., “Inhibitors of Monoamine Oxidase and Acetylcholinesterase as a Front Runner in CNS Drug Discovery.”, Comb Chem High Throughput Screen, vol. 23, no. 9, pp. 834-835, 2020.

Publisher : Comb Chem High Throughput Screen

Year : 2020

An Environment-friendly Synthesis of Piperonal Chalcones and Their Cytotoxic and Antioxidant Evaluation

Cite this Research Publication : S. Dev, Parambi, D. Grace Thom, Baby, B., Mathew, G. Elizabeth, Magdy, H. Omnia, Joy, M., Sudev, S., and Bijo Mathew, “An Environment-friendly Synthesis of Piperonal Chalcones and Their Cytotoxic and Antioxidant Evaluation”, Letters in Drug Design & Discovery, vol. 17, pp. 138-144, 2020.

Publisher : Letters in Drug Design & Discovery

Year : 2020

Magnetic nanoparticles for hyperthermia in cancer treatment: an emerging tool.

Cite this Research Publication : J. Jose, Kumar, R., Harilal, S., Mathew, G. Elizabeth, Parambi, D. Grace Thom, Prabhu, A., Uddin, M. Sahab, Aleya, L., Kim, H., and Bijo Mathew, “Magnetic nanoparticles for hyperthermia in cancer treatment: an emerging tool.”, Environ Sci Pollut Res Int, vol. 27, no. 16, pp. 19214-19225, 2020.

Publisher : Environ Sci Pollut Res Int

Year : 2019

Emerging therapeutic potentials of dual-acting MAO and AChE inhibitors in Alzheimer’s and Parkinson’s diseases.

Cite this Research Publication : Bijo Mathew, Parambi, D. G. T., Mathew, G. E., Uddin, M. Sahab, Inasu, S. T., Kim, H., Marathakam, A., Unnikrishnan, M. Kesavan, and Carradori, S., “Emerging therapeutic potentials of dual-acting MAO and AChE inhibitors in Alzheimer's and Parkinson's diseases.”, Arch Pharm (Weinheim), vol. 352, no. 11, p. e1900177, 2019.

Publisher : Arch Pharm (Weinheim)

Year : 2019

NMDA Receptor Antagonists: Repositioning of Memantine as a Multitargeting Agent for Alzheimer’s Therapy.

Cite this Research Publication : M. Tanvir Kabir, Sufian, M. A., Uddin, M. Sahab, Begum, M. Marium, Akhter, S., Islam, A., Bijo Mathew, Islam, M. Siddiqul, Amran, M. Shah, and Ashraf, G. Md, “NMDA Receptor Antagonists: Repositioning of Memantine as a Multitargeting Agent for Alzheimer's Therapy.”, Curr Pharm Des, vol. 25, no. 33, pp. 3506-3518, 2019.

Publisher : Curr Pharm Des

Year : 2019

Design, synthesis and biological evaluation of oxygenated chalcones as potent and selective MAO-B inhibitors.

Cite this Research Publication : D. Grace Thom Parambi, Oh, J. Min, Baek, S. Cheol, Lee, J. Pil, Tondo, A. Rita, Nicolotti, O., Kim, H., and Bijo Mathew, “Design, synthesis and biological evaluation of oxygenated chalcones as potent and selective MAO-B inhibitors.”, Bioorg Chem, vol. 93, p. 103335, 2019.

Publisher : Bioorg Chem

Year : 2019

Ethyl Acetohydroxamate Incorporated Chalcones: Unveiling a Novel Class of Chalcones for Multitarget Monoamine Oxidase-B Inhibitors Against Alzheimer’s Disease.

Cite this Research Publication : S. Cheol Baek, Lee, J. Pil, Rangarajan, T. M., Singh, R. Pal, Singh, M., Mangiatordi, G. Felice, Nicolotti, O., Kim, H., and Bijo Mathew, “Ethyl Acetohydroxamate Incorporated Chalcones: Unveiling a Novel Class of Chalcones for Multitarget Monoamine Oxidase-B Inhibitors Against Alzheimer's Disease.”, CNS Neurol Disord Drug Targets, vol. 18, no. 8, pp. 643-654, 2019.

Publisher : CNS Neurol Disord Drug Targets

Year : 2019

Advancements in nanotherapeutics for Alzheimer’s disease: current perspectives.

Cite this Research Publication : S. Harilal, Jose, J., Parambi, D. Grace Thom, Kumar, R., Mathew, G. Elizabeth, Uddin, M. Sahab, Kim, H., and Bijo Mathew, “Advancements in nanotherapeutics for Alzheimer's disease: current perspectives.”, J Pharm Pharmacol, vol. 71, no. 9, pp. 1370-1383, 2019.

Publisher : J Pharm Pharmacol

Year : 2019

Aptamers in Drug Design: An Emerging Weapon to Fight a Losing Battle.

Cite this Research Publication : J. Jose, Thomas, A. Mathew, Mendonsa, D., Al-Sanea, M. M., Uddin, M. Sahab, Parambi, D. Grace Thom, R Charyulu, N., and Bijo Mathew, “Aptamers in Drug Design: An Emerging Weapon to Fight a Losing Battle.”, Curr Drug Targets, vol. 20, no. 16, pp. 1624-1635, 2019.

Publisher : Curr Drug Targets

Year : 2019

Anti-inflammatory effect of synthesized indole-based chalcone (2E)-3-(4-bromophenyl)-1-(1-indol-3-yl) prop-2-en-1-one: an and studies.

Cite this Research Publication : R. Sasidharan, Leelabaiamma, M. Sreedharan, Mohanan, R., Jose, S. P., Bijo Mathew, and Sukumaran, S., “Anti-inflammatory effect of synthesized indole-based chalcone (2E)-3-(4-bromophenyl)-1-(1-indol-3-yl) prop-2-en-1-one: an and studies.”, Immunopharmacol Immunotoxicol, vol. 41, no. 6, pp. 568-576, 2019.

Publisher : Immunopharmacol Immunotoxicol

Year : 2019

Exploring the new horizons of drug repurposing: A vital tool for turning hard work into smart work.

Cite this Research Publication : R. Kumar, Harilal, S., Gupta, S. Varghese, Jose, J., Parambi, D. Grace Thom, Uddin, M. Sahab, Shah, M. Ajmal, and Bijo Mathew, “Exploring the new horizons of drug repurposing: A vital tool for turning hard work into smart work.”, Eur J Med Chem, vol. 182, p. 111602, 2019.

Publisher : Eur J Med Chem

Year : 2019

Cholinesterase Inhibitors for Alzheimer’s Disease: Multitargeting Strategy Based on Anti-Alzheimer’s Drugs Repositioning.

Cite this Research Publication : M. Tanvir Kabir, Uddin, M. Sahab, Begum, M. Marium, Thangapandiyan, S., Rahman, M. Sohanur, Aleya, L., Bijo Mathew, Ahmed, M., Barreto, G. E., and Ashraf, G. Md, “Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning.”, Curr Pharm Des, vol. 25, no. 33, pp. 3519-3535, 2019.

Publisher : Curr Pharm Des

Year : 2019

Cholinesterase Inhibitory Activities of Selected Halogenated Thiophene Chalcones.

Cite this Research Publication : D. G. T. Parambi, Aljoufi, F., Murugaiyah, V., Mathew, G. E., Dev, S., Lakshminarayanan, B., Hendawy, O. M., and Bijo Mathew, “Cholinesterase Inhibitory Activities of Selected Halogenated Thiophene Chalcones.”, Cent Nerv Syst Agents Med Chem, vol. 19, no. 1, pp. 67-71, 2019.

Publisher : Cent Nerv Syst Agents Med Chem

Year : 2019

Perspective Design of Chalcones for the Management of CNS Disorders: A Mini-Review.

Cite this Research Publication : Bijo Mathew, Parambi, D. Grace Thom, Sivasankarapillai, V. Sankar, Uddin, M. Sahab, Suresh, J., Mathew, G. Elizabeth, Joy, M., Marathakam, A., and Gupta, S. Varghese, “Perspective Design of Chalcones for the Management of CNS Disorders: A Mini-Review.”, CNS Neurol Disord Drug Targets, vol. 18, no. 6, pp. 432-445, 2019.

Publisher : CNS Neurol Disord Drug Targets

Year : 2019

Ethoxylated Head of Chalcones as a New Class of Multi-Targeted MAO Inhibitors

Cite this Research Publication : B. Lakshminarayanan, Baek, S. Cheol, Lee, J. Pil, Kannappan, N., Mangiatordi, G. Felice, Nicolotti, O., Subburaju, T., Kim, H., and Bijo Mathew, “Ethoxylated Head of Chalcones as a New Class of Multi-Targeted MAO Inhibitors”, ChemistrySelect, vol. 4, pp. 6614-6619, 2019.

Publisher : ChemistrySelect

Year : 2019

Melatonin in Alzheimer’s Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer’s Neuropathology

Cite this Research Publication : M. Farhad Hossain, Uddin, M. Sahab, Uddin, G. M. Sala, Sumsuzzman, D. Md, Islam, M. Siddiqul, Barreto, G. E., Bijo Mathew, and Ashraf, G. Md, “Melatonin in Alzheimer's Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer's Neuropathology.”, Mol Neurobiol, vol. 56, no. 12, pp. 8255-8276, 2019.

Publisher : Mol Neurobiol

Year : 2019

In Vitro Study of the Interaction Between HSA and 4-Bromoindolylchalcone, a Potent Human MAO-B Inhibitor: Spectroscopic and Molecular Modeling Studies

Cite this Research Publication : O. Augusto Chaves, Sasidharan, R., de Oliveira, C. H. C. dos, Manju, S. Leelabaiam, Joy, M., Bijo Mathew, and Netto-Ferreira, J. Carlos, “In Vitro Study of the Interaction Between HSA and 4-Bromoindolylchalcone, a Potent Human MAO-B Inhibitor: Spectroscopic and Molecular Modeling Studies”, ChemistrySelect, vol. 4, pp. 1007-1014, 2019.

Publisher : ChemistrySelect

Year : 2019

Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production.

Cite this Research Publication : M. Samsuzzaman, Uddin, M. Sahab, Shah, M. Ajmal, and Bijo Mathew, “Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production.”, Life Sci, vol. 231, p. 116485, 2019.

Publisher : Life Sci

Year : 2019

Fe O nanoparticles mediated synthesis of novel spirooxindole-dihydropyrimidinone molecules as Hsp90 inhibitors.

Cite this Research Publication : S. Maddela, Makula, A., Galigniana, M. D., Parambi, D. G. T., Federicci, F., Mazaira, G., Hendawy, O. M., Dev, S., Mathew, G. E., and Bijo Mathew, “Fe O nanoparticles mediated synthesis of novel spirooxindole-dihydropyrimidinone molecules as Hsp90 inhibitors.”, Arch Pharm (Weinheim), vol. 352, no. 1, p. e1800174, 2019.

Publisher : Arch Pharm (Weinheim)

Year : 2019

Potent and highly selective dual-targeting monoamine oxidase-B inhibitors: Fluorinated chalcones of morpholine versus imidazole

Cite this Research Publication : Bijo Mathew, Baek, S. C., Parambi, D. G. Thomas, Lee, J. P., Mathew, G. E., Jayanthi, S., Vinod, D., Rapheal, C., Devikrishna, V., Kondarath, S. Shad, Uddin, M. Sahab, and Kim, H., “Potent and highly selective dual-targeting monoamine oxidase-B inhibitors: Fluorinated chalcones of morpholine versus imidazole.”, Arch Pharm (Weinheim), vol. 352, no. 4, p. e1800309, 2019.

Publisher : Arch Pharm (Weinheim)

Year : 2019

Silicon Quantum Dots: Promising Theranostic Probes for the Future.

Cite this Research Publication : V. Sankar Sivasankarapillai, Jose, J., Shanavas, M. Salman, Marathakam, A., Uddin, M. Sahab, and Bijo Mathew, “Silicon Quantum Dots: Promising Theranostic Probes for the Future.”, Curr Drug Targets, vol. 20, no. 12, pp. 1255-1263, 2019.

Publisher : Curr Drug Targets

Year : 2019

Nootropic and Anti-Alzheimer’s Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer’s Neuropathology

Cite this Research Publication : M. Sahab Uddin, Mamun, A. Al, Kabir, M. Tanvir, Jakaria, M., Bijo Mathew, Barreto, G. E., and Ashraf, G. Md, “Nootropic and Anti-Alzheimer's Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer's Neuropathology.”, Mol Neurobiol, vol. 56, no. 7, pp. 4925-4944, 2019.

Publisher : Mol Neurobiol

Year : 2018

Imidazole bearing chalcones as a new class of monoamine oxidase inhibitors.

Cite this Research Publication : R. Sasidharan, Baek, S. Cheol, Leelabaiamma, M. Sreedharan, Kim, H., and Bijo Mathew, “Imidazole bearing chalcones as a new class of monoamine oxidase inhibitors.”, Biomed Pharmacother, vol. 106, pp. 8-13, 2018.

Publisher : Biomed Pharmacothe

Year : 2018

Virtual combinatorial library design, synthesis and in vitro anticancer assessment of -2-amino-3-cyanopyridine derivatives

Cite this Research Publication : D. S., ,, and Bijo Mathew, “Virtual combinatorial library design, synthesis and in vitro anticancer assessment of -2-amino-3-cyanopyridine derivatives”, Combinatorial Chemistry and High Throughput Screening. [Bentham Science], vol. 21, pp. 138-148, 2018.

Publisher : Combinatorial Chemistry and High Throughput Screening. [Bentham Science]

Year : 2018

Structural and optical profile of a multifunctionalized 2-pyridone derivative in a crystal engineering perspective.

Cite this Research Publication : M. Joy, Anabha, E. R., Gopi, S., Bijo Mathew, S, A. Kumar, and Mathews, A., “Structural and optical profile of a multifunctionalized 2-pyridone derivative in a crystal engineering perspective.”, Acta Crystallogr C Struct Chem, vol. 74, no. Pt 7, pp. 807-815, 2018.

Publisher : Acta Crystallogr C Struct Chem

Year : 2018

Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.

Cite this Research Publication : Bijo Mathew, Baek, S. Cheol, Parambi, D. Grace Thom, Lee, J. Pil, Joy, M., Rilda, P. R. Annie, Randev, R. V., Nithyamol, P., Vijayan, V., Inasu, S. T., Mathew, G. Elizabeth, Lohidakshan, K. K., Krishnan, G. Kumar, and Kim, H., “Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.”, Medchemcomm, vol. 9, no. 11, pp. 1871-1881, 2018.

Publisher : Medchemcomm

Year : 2018

Dual acting Isatin-Heterocyclic Hybrids: Recent Highlights as Promising Pharmacological Agents

Cite this Research Publication : Bijo Mathew, “Dual acting Isatin-Heterocyclic Hybrids: Recent Highlights as Promising Pharmacological Agents”, vol. 15, 2018.

Publisher : Volume 15

Year : 2018

Discovery of new class of methoxy carrying isoxazole derivatives as COX-II inhibitors: Investigation of a detailed molecular dynamics study

Cite this Research Publication : M. Joy, Elrashedy, A. A., Bijo Mathew, Pillay, A. Singh, Mathews, A., Dev, S., Soliman, M. E. S., and Sudarsanakumar, C., “Discovery of new class of methoxy carrying isoxazole derivatives as COX-II inhibitors: Investigation of a detailed molecular dynamics study”, Journal of Molecular Structure, vol. 1157, pp. 19-28, 2018.

Publisher : Journal of Molecular Structure

Year : 2018

Discovery of potent and reversible MAO-B inhibitors as furanochalcones

Cite this Research Publication : J. Suresh, Baek, S. Cheol, Ramakrishnan, S. Parakkot, Kim, H., and Bijo Mathew, “Discovery of potent and reversible MAO-B inhibitors as furanochalcones”, International Journal of Biological Macromolecules, vol. 108, pp. 660-664, 2018.

Publisher : International Journal of Biological Macromolecules

Year : 2018

Introduction of fluorinated environment on metformin. Evaluation of its serum-albumin interaction with molecular modeling studies

Cite this Research Publication : O. Augusto Chaves, Bijo Mathew, Joy, M., Lohidakshan, K. K., Marathakam, A., and Netto-Ferreira, J. Carlos, “Introduction of fluorinated environment on metformin. Evaluation of its serum-albumin interaction with molecular modeling studies”, Journal of Molecular Liquids, vol. 260, pp. 186-194, 2018.

Publisher : Journal of Molecular Liquids

Year : 2018

Structural features of Safinamide: A combined Hirshfeld surface analysis & quantum chemical treatment

Cite this Research Publication : M. Joy, Bijo Mathew, and Sudarsanakumar, C., “Structural features of Safinamide: A combined Hirshfeld surface analysis & quantum chemical treatment”, Chemical Data Collections, vol. 17-18, pp. 404-414, 2018.

Publisher : Chemical Data Collections

Year : 2017

Monoamine oxidase inhibitory activity of methoxy-substituted chalcones.

Cite this Research Publication : Bijo Mathew, Mathew, G. Elizabeth, Ucar, G., Joy, M., Nafna, E. K., Lohidakshan, K. K., and Suresh, J., “Monoamine oxidase inhibitory activity of methoxy-substituted chalcones.”, Int J Biol Macromol, vol. 104, no. Pt A, pp. 1321-1329, 2017.

Publisher : Int J Biol Macromol

Year : 2017

Pharmacophore-Based 3D-QSAR Analysis of Thienyl Chalcones as a New Class of Human MAO-B Inhibitors: Investigation of Combined Quantum Chemical and Molecular Dynamics Approach.

Cite this Research Publication : Bijo Mathew, Adeniyi, A. A., Dev, S., Joy, M., Ucar, G., Mathew, G. Elizabeth, Singh-Pillay, A., and Soliman, M. E. S., “Pharmacophore-Based 3D-QSAR Analysis of Thienyl Chalcones as a New Class of Human MAO-B Inhibitors: Investigation of Combined Quantum Chemical and Molecular Dynamics Approach.”, J Phys Chem B, vol. 121, no. 6, pp. 1186-1203, 2017.

Publisher : J Phys Chem B

Year : 2017

Molecular modeling of drug-pathophysiological Mtb protein targets: Synthesis of some 2-thioxo-1, 3-thiazolidin-4-one derivatives as anti-tubercular agents

Cite this Research Publication : K. M. Noorulla, Suresh, A. Jerad, Devaraji, V., Bijo Mathew, and Umesh, D., “Molecular modeling of drug-pathophysiological Mtb protein targets: Synthesis of some 2-thioxo-1, 3-thiazolidin-4-one derivatives as anti-tubercular agents”, Journal of Molecular Structure, vol. 1147, pp. 682-696, 2017.

Publisher : Journal of Molecular Structure

Year : 2017

Spectroscopic, zeta potential and molecular docking analysis on the interaction between human serum albumin and halogenated thienyl chalcones

Cite this Research Publication : O. Augusto Chaves, Bijo Mathew, Cesarin-Sobrinho, D., Lakshminarayanan, B., Joy, M., Mathew, G. Elizabeth, Suresh, J., and Netto-Ferreira, J. Carlos, “Spectroscopic, zeta potential and molecular docking analysis on the interaction between human serum albumin and halogenated thienyl chalcones”, Journal of Molecular Liquids, vol. 242, pp. 1018-1026, 2017.

Publisher : Journal of Molecular Liquids

Year : 2017

Synthetic Approaches to Various Class of Topoisomerase II Inhibitors

Cite this Research Publication : S. Dev, Gabhe, N., Dhaneshwar, S. R., Joy, M., and Bijo Mathew, “Synthetic Approaches to Various Class of Topoisomerase II Inhibitors”, Mini-Reviews in Organic Chemistry, vol. 14, pp. 357-374, 2017.

Publisher : Mini-Reviews in Organic Chemistry

Year : 2017

Probing mechanism of α-formylketene dithioacetal towards the facile formation of functionalized pyrimidines: A structural approach

Cite this Research Publication : M. Joy, Adeniyi, A. A., Mathews, A., Bijo Mathew, Prasanth, S., Soliman, M. E. S., Malayan, J. J., and Anabha, E. R., “Probing mechanism of α-formylketene dithioacetal towards the facile formation of functionalized pyrimidines: A structural approach”, Journal of Molecular Structure, vol. 1127, pp. 498-510, 2017.

Publisher : Journal of Molecular Structure

Year : 2017

Anti-oxidant behavior of functionalized chalcone-a combined quantum chemical and crystallographic structural investigation

Cite this Research Publication : Bijo Mathew, Adeniyi, A. A., Joy, M., Mathew, G. Elizabeth, Singh-Pillay, A., Sudarsanakumar, C., Soliman, M. E. S., and Suresh, J., “Anti-oxidant behavior of functionalized chalcone-a combined quantum chemical and crystallographic structural investigation”, Journal of Molecular Structure, vol. 1146, pp. 301-308, 2017.

Publisher : Journal of Molecular Structure

Year : 2017

Characterization of Thienylchalcones as hMAO-B Inhibitors: Synthesis, Biochemistry and Molecular Dynamics Studies

Cite this Research Publication : Bijo Mathew, Ucar, G., Rapheal, C., Mathew, G. E., Joy, M., Machaba, K. E., and Soliman, M. E. S., “Characterization of Thienylchalcones as hMAO-B Inhibitors: Synthesis, Biochemistry and Molecular Dynamics Studies”, ChemistrySelect, vol. 2, pp. 11113-11119, 2017.

Publisher : ChemistrySelect, Volume 2

Year : 2017

Molecular Docking, Synthesis and CNS Activity of Some Novel 1, 4-Benzodiazepine Derivatives

Cite this Research Publication : S. S. Menghani*, Chikhale, R., Pant, A., Bijo Mathew, and Khedekar, P., “Molecular Docking, Synthesis and CNS Activity of Some Novel 1, 4-Benzodiazepine Derivatives”, 2017.

Year : 2017

Structural Exploration of Synthetic Chromones as Selective MAO-B Inhibitors: A Mini Review.

Cite this Research Publication : Bijo Mathew, Mathew, G. Elizabeth, Petzer, J. P., and Petzer, A., “Structural Exploration of Synthetic Chromones as Selective MAO-B Inhibitors: A Mini Review.”, Comb Chem High Throughput Screen, vol. 20, no. 6, pp. 522-532, 2017.

Publisher : Comb Chem High Throughput Screen

Year : 2017

Refining the Structural Features of Chromones as Selective MAO-B Inhibitors: Exploration of Combined Pharmacophore-Based 3D-QSAR and Quantum Chemical Studies

Cite this Research Publication : Bijo Mathew, Dev, S., Joy, M., Mathew, G. E., Marathakam, A., and Krishnan, G. K., “Refining the Structural Features of Chromones as Selective MAO-B Inhibitors: Exploration of Combined Pharmacophore-Based 3D-QSAR and Quantum Chemical Studies”, ChemistrySelectChemistrySelectChemistrySelect, vol. 2, no. 35, pp. 11645 - 11652, 2017.

Publisher : John Wiley & Sons, Ltd

Year : 2016

Monoamine Oxidase Inhibitory Activity: Methyl- versus Chlorochalcone Derivatives.

Cite this Research Publication : Bijo Mathew, Ucar, G., Mathew, G. Elizabeth, Mathew, S., Purapurath, P. Kalatharak, Moolayil, F., Mohan, S., and Gupta, S. Varghese, “Monoamine Oxidase Inhibitory Activity: Methyl- versus Chlorochalcone Derivatives.”, ChemMedChem, vol. 11, no. 24, pp. 2649-2655, 2016.

Publisher : ChemMedChem

Year : 2016

Synthesis, Biochemistry, and Computational Studies of Brominated Thienyl Chalcones: A New Class of Reversible MAO-B Inhibitors.

Cite this Research Publication : Bijo Mathew, Haridas, A., Ucar, G., Baysal, I., Joy, M., Mathew, G. E., Lakshmanan, B., and Jayaprakash, V., “Synthesis, Biochemistry, and Computational Studies of Brominated Thienyl Chalcones: A New Class of Reversible MAO-B Inhibitors.”, ChemMedChem, vol. 11, no. 11, pp. 1161-71, 2016.

Publisher : ChemMedChem

Year : 2016

Exploration of chlorinated thienyl chalcones: A new class of monoamine oxidase-B inhibitors.

Cite this Research Publication : Bijo Mathew, Haridas, A., Ucar, G., Baysal, I., Adeniyi, A. A., Soliman, M. E. S., Joy, M., Mathew, G. Elizabeth, Lakshmanan, B., and Jayaprakash, V., “Exploration of chlorinated thienyl chalcones: A new class of monoamine oxidase-B inhibitors.”, Int J Biol Macromol, vol. 91, pp. 680-95, 2016.

Publisher : Int J Biol Macromol

Year : 2016

Ligand based drug design of new heterocyclic imines of GABA analogues: A molecular docking approach for the discovery of new GABA-AT inhibitors.

Cite this Research Publication : Bijo Mathew, Mathew, G. Elizabeth, Suresh, J., Usman, D., Subramanyan, P. Natarajan, and Safna, K. Fathima, “Ligand based drug design of new heterocyclic imines of GABA analogues: A molecular docking approach for the discovery of new GABA-AT inhibitors.”, Cent Nerv Syst Agents Med Chem, 2016.

Publisher : Cent Nerv Syst Agents Med Chem

Year : 2016

Identification of Indole-Based Chalcones: Discovery of a Potent, Selective, and Reversible Class of MAO-B Inhibitors.

Cite this Research Publication : R. Sasidharan, Manju, S. Leelabaiam, Ucar, G., Baysal, I., and Bijo Mathew, “Identification of Indole-Based Chalcones: Discovery of a Potent, Selective, and Reversible Class of MAO-B Inhibitors.”, Arch Pharm (Weinheim), vol. 349, no. 8, pp. 627-37, 2016.

Publisher : Arch Pharm (Weinheim)

Year : 2016

Discovery of Camptothecin Based Topoisomerase I Inhibitors: Identification Using an Atom Based 3D-QSAR, Pharmacophore Modeling, Virtual Screening and Molecular Docking Approach.

Cite this Research Publication : S. Dev, Dhaneshwar, S. R., and Bijo Mathew, “Discovery of Camptothecin Based Topoisomerase I Inhibitors: Identification Using an Atom Based 3D-QSAR, Pharmacophore Modeling, Virtual Screening and Molecular Docking Approach.”, Comb Chem High Throughput Screen, vol. 19, no. 9, pp. 752-763, 2016.

Publisher : Comb Chem High Throughput Screen

Year : 2016

Development of novel (1-H) benzimidazole bearing pyrimidine-trione based MAO-A inhibitors: Synthesis, docking studies and antidepressant activity

Cite this Research Publication : Bijo Mathew, Suresh, J., and Anbazhagan, S., “Development of novel (1-H) benzimidazole bearing pyrimidine-trione based MAO-A inhibitors: Synthesis, docking studies and antidepressant activity”, Journal of Saudi Chemical Society, vol. 20, pp. S132-S139, 2016.

Publisher : Journal of Saudi Chemical Society

Year : 2016

Discovery of some novel imines of 2-amino, 5-thio, 1,3,4-thiadiazole as mucomembranous protector. Synthesis, anti-oxidant activity and in silico PASS approach

Cite this Research Publication : Bijo Mathew, Suresh, J., Anbazhagan, S., and Chidambaranathan, N., “Discovery of some novel imines of 2-amino, 5-thio, 1,3,4-thiadiazole as mucomembranous protector. Synthesis, anti-oxidant activity and in silico PASS approach”, Journal of Saudi Chemical Society, vol. 20, pp. S426-S432, 2016.

Publisher : Journal of Saudi Chemical Society

Year : 2016

Potent and Selective Monoamine Oxidase-B Inhibitory Activity: Fluoro- vs. Trifluoromethyl-4-hydroxylated Chalcone Derivatives.

Cite this Research Publication : Bijo Mathew, Mathew, G. Elizabeth, Ucar, G., Baysal, I., Suresh, J., Mathew, S., Haridas, A., and Jayaprakash, V., “Potent and Selective Monoamine Oxidase-B Inhibitory Activity: Fluoro- vs. Trifluoromethyl-4-hydroxylated Chalcone Derivatives.”, Chem Biodivers, vol. 13, no. 8, pp. 1046-52, 2016.

Publisher : Chem Biodivers

Year : 2016

Monoamine Oxidase Inhibitors: Perspective Design for the Treatment of Depression and Neurological Disorders

Cite this Research Publication : Bijo Mathew, Mathew, G. E., Suresh, J., Ucar, G., Sasidharan, R., Anbazhagan, S., and Jayaprakash, J. K. Vilapur, “Monoamine Oxidase Inhibitors: Perspective Design for the Treatment of Depression and Neurological Disorders”, 2016.

Year : 2016

Molecular Docking Studies of Some Novel Antidepressant 5-Substituted Phenyl-3-(Thiophen-2-yl)-4, 5-Dihydro-1h-Pyrazole-1-Carboxamides Against Monoamine Oxidase Isoforms.

Cite this Research Publication : Bijo Mathew, Suresh, J., Anbazhagan, S., and Dev, S., “Molecular Docking Studies of Some Novel Antidepressant 5-Substituted Phenyl-3-(Thiophen-2-yl)-4, 5-Dihydro-1h-Pyrazole-1-Carboxamides Against Monoamine Oxidase Isoforms.”, Cent Nerv Syst Agents Med Chem, vol. 16, no. 2, pp. 75-80, 2016.

Publisher : Cent Nerv Syst Agents Med Chem

Year : 2016

Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review.

Cite this Research Publication : Bijo Mathew, Haridas, A., Suresh, J., Mathew, G. E., Ucar, G., and Jayaprakash, V., “Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review.”, Cent Nerv Syst Agents Med Chem, vol. 16, no. 2, pp. 120-36, 2016.

Publisher : Cent Nerv Syst Agents Med Chem

Year : 2016

Pharmacophore Modeling, 3D-QSAR and Molecular Docking of Furanochalcones as Inhibitors of Monoamine Oxidase-B.

Cite this Research Publication : Bijo Mathew, Dev, S., Suresh, J., Mathew, G. E., Lakshmanan, B., Haridas, A., Fathima, F., and Krishnan, G. K., “Pharmacophore Modeling, 3D-QSAR and Molecular Docking of Furanochalcones as Inhibitors of Monoamine Oxidase-B.”, Cent Nerv Syst Agents Med Chem, vol. 16, no. 2, pp. 105-11, 2016.

Publisher : Cent Nerv Syst Agents Med Chem

Year : 2016

Synthesis, ADME studies, toxicity estimation, and exploration of molecular recognition of thiophene based chalcones towards monoamine oxidase-A and B

Cite this Research Publication : Bijo Mathew, Suresh, J., Mathew, G. Elizabeth, Haridas, A., Suresh, G., and Sabreena, P., “Synthesis, ADME studies, toxicity estimation, and exploration of molecular recognition of thiophene based chalcones towards monoamine oxidase-A and B”, vol. 5, no. 4, pp. 396 - 401, 2016.

Publisher : Volume 5, Issue 4, p.396 - 401 (2016)

Year : 2015

Development of Fluorinated Thienylchalcones as Monoamine Oxidase-B Inhibitors: Design, Synthesis, Biological Evaluation and Molecular Docking Studies

Cite this Research Publication : Bijo Mathew, Ucar, G., Yabanogclu-Ciftci, S., Baysal, I., Suresh, J., Mathew, G. Elizabeth, Vilapurathu, J. Kunjumon, Nadeena, A. M., Nabeela, P., Lakshmi, V., and Fathima, A. Haridas an, “Development of Fluorinated Thienylchalcones as Monoamine Oxidase-B Inhibitors: Design, Synthesis, Biological Evaluation and Molecular Docking Studies”, 2015.

Year : 2015

Psychomotor Seizure Screening and in vitro Neuroprotection Assay of Hydrazones Derived from 2-Acetyl Thiophene.

Cite this Research Publication : Bijo Mathew, Mathew, G. E., Suresh, J., Jaseel, M., Usman, D., Subramanyan, P. N. Shiva, Safna, K. F., and Vilapurathu, J. K., “Psychomotor Seizure Screening and in vitro Neuroprotection Assay of Hydrazones Derived from 2-Acetyl Thiophene.”, Cent Nerv Syst Agents Med Chem, 2015.

Publisher : Cent Nerv Syst Agents Med Chem

Year : 2015

Determination of in vitro free radical scavenging and antiproliferative effect of Pennisetum alopecuroides on cultured A549 human lung cancer cells.

Cite this Research Publication : G. Elizabeth Mathew, Bijo Mathew, Gokul, S., Krishna, R., and Farisa, M. P., “Determination of in vitro free radical scavenging and antiproliferative effect of Pennisetum alopecuroides on cultured A549 human lung cancer cells.”, Anc Sci Life, vol. 34, no. 3, pp. 175-8, 2015.

Publisher : Anc Sci Life

Year : 2015

Development of fluorinated methoxylated chalcones as selective monoamine oxidase-B inhibitors: Synthesis, biochemistry and molecular docking studies.

Cite this Research Publication : Bijo Mathew, Mathew, G. Elizabeth, Ucar, G., Baysal, I., Suresh, J., Vilapurathu, J. Kunjumon, Prakasan, A., Suresh, J. Kuruppath, and Thomas, A., “Development of fluorinated methoxylated chalcones as selective monoamine oxidase-B inhibitors: Synthesis, biochemistry and molecular docking studies.”, Bioorg Chem, vol. 62, pp. 22-9, 2015.

Publisher : Bioorg Chem

Year : 2015

Flavonoids: An Outstanding Structural Core for the Inhibition of Xanthine Oxidase Enzyme

Cite this Research Publication : Bijo Mathew, Suresh, J., Mathew, G. E., Rasheed, S. A., and Jayaraj, J. K. Vilapur, “Flavonoids: An Outstanding Structural Core for the Inhibition of Xanthine Oxidase Enzyme”, 2015.

Year : 2015

Molecular Hybridization and Preclinical Evaluation of Imines From Para-substituted 4-phenyl 2-amino Thiazole Incorporated with Isatin Analogues as Antitubercular Agents

Cite this Research Publication : N. Joy and Bijo Mathew, “Molecular Hybridization and Preclinical Evaluation of Imines From Para-substituted 4-phenyl 2-amino Thiazole Incorporated with Isatin Analogues as Antitubercular Agents”, Anti-Infective Agents, 13 vol., no. 1, 2015.

Publisher : Anti-Infective Agents

Year : 2015

Hydrazones as a privileged structural linker in antitubercular agents: a review.

Cite this Research Publication : Bijo Mathew, Suresh, J., Ahsan, M. J., Mathew, G. E., Usman, D., Subramanyan, P. N. S., Safna, K. F., and Maddela, S., “Hydrazones as a privileged structural linker in antitubercular agents: a review.”, Infect Disord Drug Targets, vol. 15, no. 2, pp. 76-88, 2015.

Publisher : Infect Disord Drug Targets

Year : 2014

Molecular Recognisation of 3a, 4-Dihydro-3-H-Indeno [1, 2-C] Pyrazole-2- Carboxamide/Carbothioamide Anticonvulsant Analogues Towards GABA-Aminotransferase- An in Silico Approach

Cite this Research Publication : Bijo Mathew and Ahsan, M., “Molecular Recognisation of 3a, 4-Dihydro-3-H-Indeno [1, 2-C] Pyrazole-2- Carboxamide/Carbothioamide Anticonvulsant Analogues Towards GABA-Aminotransferase- An in Silico Approach”, Central Nervous System Agents in Medicinal Chemistry, vol. 14, 2014.

Publisher : Central Nervous System Agents in Medicinal Chemistry

Year : 2014

Isolation of chemical constituents from Spilanthes calva DC: Toxicity, anthelmintic efficacy and in silico studies

Cite this Research Publication : P. Jayaraj, Bijo Mathew, Mani, C., and Govindarajan, R., “Isolation of chemical constituents from Spilanthes calva DC: Toxicity, anthelmintic efficacy and in silico studies”, Biomedicine & Preventive Nutrition, vol. 4, pp. 417-423, 2014.

Publisher : Biomedicine & Preventive Nutrition

Year : 2014

Synthesis, preclinical evaluation and antidepressant activity of 5-substituted phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1H-pyrazole-1-carbothioamides.

Cite this Research Publication : Bijo Mathew, Suresh, J., and Anbazhagan, S., “Synthesis, preclinical evaluation and antidepressant activity of 5-substituted phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1H-pyrazole-1-carbothioamides.”, EXCLI J, vol. 13, pp. 437-45, 2014.

Publisher : EXCLI J

Year : 2014

Design, Synthesis, Toxicity Estimation and Molecular Docking Studies of N-(furan-2-yl)-1-(5-substituted) phenyl-1,3,4-oxadiazol-2-yl) methanimine as Antitubercular Agents.

Cite this Research Publication : Bijo Mathew, Suresh, J., Mathew, G. E., Sonia, G., and Krishnan, G. K., “Design, Synthesis, Toxicity Estimation and Molecular Docking Studies of N-(furan-2-yl)-1-(5-substituted) phenyl-1,3,4-oxadiazol-2-yl) methanimine as Antitubercular Agents.”, Indian J Pharm Sci, vol. 76, no. 5, pp. 401-6, 2014.

Publisher : Indian J Pharm Sci

Year : 2014

Plant secondary metabolites- potent inhibitors of monoamine oxidase isoforms.

Cite this Research Publication : Bijo Mathew, Suresh, J., Mathew, G. E., Parasuraman, R., and Abdulla, N., “Plant secondary metabolites- potent inhibitors of monoamine oxidase isoforms.”, Cent Nerv Syst Agents Med Chem, vol. 14, no. 1, pp. 28-33, 2014.

Publisher : Cent Nerv Syst Agents Med Chem

Year : 2014

Proposed interaction of some novel antidepressant pyrazolines against monoamine oxidase isoforms. Molecular docking studies and PASS assisted in silico approach

Cite this Research Publication : Bijo Mathew, Suresh, J., Anbazhagan, S., and Dev, S., “Proposed interaction of some novel antidepressant pyrazolines against monoamine oxidase isoforms. Molecular docking studies and PASS assisted in silico approach”, Biomedicine & Aging Pathology, vol. 4, pp. 297-301, 2014.

Publisher : Biomedicine & Aging Pathology

Year : 2014

Isolation and molecular recognization of 6-prenyl apigenin towards MAO-A as the active principle of seeds of Achyranthes aspera

Cite this Research Publication : S. Janet Beula, V. Raj, B. Anada, and Bijo Mathew, “Isolation and molecular recognization of 6-prenyl apigenin towards MAO-A as the active principle of seeds of Achyranthes aspera”, Biomedicine & Preventive Nutrition, vol. 4, pp. 379-382, 2014.

Publisher : Biomedicine & Preventive Nutrition

Year : 2014

Synthesis, in silico preclinical evaluation, antidepressant potential of 5-substituted phenyl-3-(thiophen-2-yl)-4,5-dihydro-1h-pyrazole-1-carboxamides

Cite this Research Publication : Bijo Mathew, Suresh, J., and Anbazhagan, S., “Synthesis, in silico preclinical evaluation, antidepressant potential of 5-substituted phenyl-3-(thiophen-2-yl)-4,5-dihydro-1h-pyrazole-1-carboxamides”, Biomedicine & Aging Pathology, vol. 4, pp. 327-333, 2014.

Publisher : Biomedicine & Aging Pathology

Year : 2014

Isolation of a bioactive flavonoid from Spilanthes calva D.C. in vitro xanthine oxidase assay and in silico study

Cite this Research Publication : P. Jayaraj, Bijo Mathew, Parimaladevi, B., V. Ramani, A., and Govindarajan, R., “Isolation of a bioactive flavonoid from Spilanthes calva D.C. in vitro xanthine oxidase assay and in silico study”, Biomedicine & Preventive Nutrition, vol. 4, pp. 481-484, 2014.

Publisher : Biomedicine & Preventive Nutrition

Year : 2014

Heteroaryl chalcones: Mini review about their therapeutic voyage

Cite this Research Publication : Bijo Mathew, Suresh, J., Anbazghagan, S., Paulraj, J., and Krishnan, G. K., “Heteroaryl chalcones: Mini review about their therapeutic voyage”, Biomedicine & Preventive Nutrition, vol. 4, pp. 451-458, 2014.

Publisher : Biomedicine & Preventive Nutrition

Year : 2013

Synthesis and in silico design of some novel imines of 5- amino-1,3,4-thiadiazole-2-thiol linked to (1h-benzimidazole-2-yl) 3-substituted phenyl prop-2-enes

Cite this Research Publication : Bijo Mathew, Suresh, J., and Anbazhagan, S., “Synthesis and in silico design of some novel imines of 5- amino-1,3,4-thiadiazole-2-thiol linked to (1h-benzimidazole-2-yl) 3-substituted phenyl prop-2-enes”, Indian. J. Heterocycl. Chem, vol. 22, pp. 337-340, 2013.

Publisher : Indian. J. Heterocycl. Chem

Year : 2013

Pyrazoline: a promising scaffold for the inhibition of monoamine oxidase.

Cite this Research Publication : Bijo Mathew, Suresh, J., Anbazhagan, S., and Mathew, G. Elizabeth, “Pyrazoline: a promising scaffold for the inhibition of monoamine oxidase.”, Cent Nerv Syst Agents Med Chem, vol. 13, no. 3, pp. 195-206, 2013.

Publisher : Cent Nerv Syst Agents Med Chem

Year : 2013

Antitumour activity of 5-[(2E)-1-(1H-benzimidazol-2-yl)-3-substituted phenylprop-2-en-1-ylidene] pyrimidine-2,4,6(1H,3H,5H)-triones against Dalton’s ascitic lymphoma in mice

Cite this Research Publication : Bijo Mathew, Suresh, J., and Vinod, D., “Antitumour activity of 5-[(2E)-1-(1H-benzimidazol-2-yl)-3-substituted phenylprop-2-en-1-ylidene] pyrimidine-2,4,6(1H,3H,5H)-triones against Dalton’s ascitic lymphoma in mice”, Medicinal Chemistry Research, vol. 22, no. 8, pp. 3911 - 3917, 2013.

Publisher : Medicinal Chemistry Research

Year : 2013

Design of 1-(furan-2-yl)-N-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl) methanimine derivatives as Enoyl-ACP reductase inhibitors: Synthesis, molecular docking studies and anti-tubercular activity

Cite this Research Publication : Bijo Mathew, Mathew, G., Sonia, G., Kumar, A., Charles, N., and Kumar, P., “Design of 1-(furan-2-yl)-N-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl) methanimine derivatives as Enoyl-ACP reductase inhibitors: Synthesis, molecular docking studies and anti-tubercular activity”, Bangladesh Journal of Pharmacology, vol. 8, 2013.

Publisher : Bangladesh Journal of Pharmacology

Year : 2013

Hypnotic profile of imines from benzimidazole chalcones: mechanism of synthesis, DFT studies and in silico screening.

Cite this Research Publication : Bijo Mathew, Suresh, J., Anbazhagan, S., and Devaraji, V., “Hypnotic profile of imines from benzimidazole chalcones: mechanism of synthesis, DFT studies and in silico screening.”, Cent Nerv Syst Agents Med Chem, vol. 13, no. 3, pp. 207-16, 2013.

Publisher : Cent Nerv Syst Agents Med Chem

Year : 2013

Synthesis and PASS-assisted in silico approach of some novel 2-substituted benzimidazole bearing a pyrimidine-2, 4, 6(trione) system as mucomembranous protector.

Cite this Research Publication : Bijo Mathew, Suresh, J., and Anbazhagan, S., “Synthesis and PASS-assisted in silico approach of some novel 2-substituted benzimidazole bearing a pyrimidine-2, 4, 6(trione) system as mucomembranous protector.”, J Pharm Bioallied Sci, vol. 5, no. 1, pp. 39-43, 2013.

Publisher : J Pharm Bioallied Sci

Year : 2012

A Green route approach of α, β unsaturated ketone having a benzimidazole tail and their virtual screening on the molecular descriptors for predicting the CNS-drug likeness

Cite this Research Publication : Bijo Mathew, Mathew, G. Elizebeth, ,, C., M. Musthafa, and P., F., “A Green route approach of α, β unsaturated ketone having a benzimidazole tail and their virtual screening on the molecular descriptors for predicting the CNS-drug likeness”, Asian J. Research Chem., vol. 5, no. 1, pp. 65-68, 2012.

Publisher : Asian J. Research Chem

Year : 2012

Isolation, in silico design and anti-inflammatory activity of spirosolenol from the roots of Solanum anguvi

Cite this Research Publication : Bijo Mathew, Mathew, G. E., George, S., Shamnas, M., and Raj, V. B. A., “Isolation, in silico design and anti-inflammatory activity of spirosolenol from the roots of Solanum anguvi”, Chemical Sciences Journal, 2012.

Publisher : Chemical Sciences Journal

Year : 2012

Microwave Assisted Synthesis, Physico-chemical Properties and Antioxidant Activity of alpha,beta-Unsaturated Benzimidazole Derivatives Incorporated with Baritone Moiety

Cite this Research Publication : Bijo Mathew, Suresh, J., and Anbazhagan, S., “Microwave Assisted Synthesis, Physico-chemical Properties and Antioxidant Activity of alpha,beta-Unsaturated Benzimidazole Derivatives Incorporated with Baritone Moiety”, ASIAN JOURNAL OF CHEMISTRY, vol. 25, pp. 1853-1856, 2012.

Publisher : ASIAN JOURNAL OF CHEMISTRY

Year : 2011

Synthesis of some thiazolidinone derivatives from indole-2 carboxylic acid and evaluation of its xanthine oxidase inhibitory and antioxidant activity

Cite this Research Publication : B. C, B., M., A., M., and M., S., “Synthesis of some thiazolidinone derivatives from indole-2 carboxylic acid and evaluation of its xanthine oxidase inhibitory and antioxidant activity”, International Journal of ChemTech Research, vol. 3, no. 2, pp. 671-675, 2011.

Publisher : International Journal of ChemTech Research

Year : 2011

Diuretic activity of leaves of garcinia cambogia in rats.

Cite this Research Publication : G. E. Mathew, Bijo Mathew, Shaneeb, M. M., and Nyanthara, B., “Diuretic activity of leaves of garcinia cambogia in rats.”, Indian J Pharm Sci, vol. 73, no. 2, pp. 228-30, 2011.

Publisher : Indian J Pharm Sci

Year : 2011

Phytochemical evaluation and lipid lowering property of leaves of Vitex negun- do linn. in hyper cholestremic rats

Cite this Research Publication : E. Githa, Mathew,, and Bijo Mathew, “Phytochemical evaluation and lipid lowering property of leaves of Vitex negun- do linn. in hyper cholestremic rats”, IJPSRR, vol. 2, 2011.

Publisher : IJPSRR

Year : 2011

Synthesis, characterization and antimicrobial screening of some 2-amino, 5(phenyl substituted) 1, 3, 4-thiadiazole derivatives

Cite this Research Publication : Bijo Mathew, AJ, J., GE, M., S, S., and SS, K., “Synthesis, characterization and antimicrobial screening of some 2-amino, 5(phenyl substituted) 1, 3, 4-thiadiazole derivatives”, International Journal of ChemTech Research, vol. 1, no. 3, pp. 364-368, 2011.

Publisher : International Journal of ChemTech Research

Year : 2011

Anthelmintic activity of leaves of garcinia cambogia

Cite this Research Publication : G. E. Mathew, Bijo Mathew, Sheneeb, M., Nyanthara, N., and Haribabu, Y., “Anthelmintic activity of leaves of garcinia cambogia”, International Journal of Research in Pharmaceutical Sciences, vol. 2, pp. 63-65, 2011.

Publisher : International Journal of Research in Pharmaceutical Sciences

Year : 2010

Synthesis, molecular properties and anthelmintic activity of some schiff bases of 1, 3, 4 thiadiazole derivatives

Cite this Research Publication : B. Mathew, Vakketh, S. S., and Kumar, S. S., “Synthesis, molecular properties and anthelmintic activity of some schiff bases of 1, 3, 4 thiadiazole derivatives”, Der pharma chemica, vol. 2, pp. 337-343, 2010.

Publisher : Der pharma chemica

Year : 2010

Synthesis, Characterisation of some 2-azetidinone derivatives from 2-aminopyridine and evaluation of their antimicrobial activity

Cite this Research Publication : Bijo Mathew, Mathew, G. Elizebeth, Mathew, N., and Vijayabaskaran, M., “Synthesis, Characterisation of some 2-azetidinone derivatives from 2-aminopyridine and evaluation of their antimicrobial activity”, Der Pharma Chemica, vol. 2, no. 6, pp. 238-242, 2010.

Publisher : Der Pharma Chemica

Year : 2010

Phytochemical evaluation and anticancer screening of rhizomes of Kaempferia galanga

Cite this Research Publication : Bijo Mathew, M, V., GE, M., and KM, T., “Phytochemical evaluation and anticancer screening of rhizomes of Kaempferia galanga”, InternationalResearch Journal of Pharmaceutical Sciences, vol. 1, no. 1, pp. 11-15, 2010.

Publisher : InternationalResearch Journal of Pharmaceutical Sciences

Book Chapter

Year : 2021

Protopine, Naturally Occurring Chemicals Against Alzheimer’s Disease

Cite this Research Publication : Bijo Mathew, Parambi D.G.T., Singh M., Hendawy O.M., and Al-Sanea M.M. Bakr R.B., “Protopine, Naturally Occurring Chemicals Against Alzheimer's Disease”, Academic Press [Elsevier Publication], 2021, pp. 167-174.

Publisher : Academic Press [Elsevier Publication]

Year : 2020

Demographic and Epidemiological Aspects of Aging

Cite this Research Publication : Parambi D.G.T., Unnikrishnan M.K., Marathakam A., and Bijo Mathew, “Demographic and Epidemiological Aspects of Aging”, in In: Nabavi S.M., D'Onofrio G., Nabavi S.F. (eds) Nutrients and Nutraceuticals for Active & Healthy Ageing, Singapore: Springer Singapore, 2020, pp. 1 - 14.

Publisher : Nabavi S.M., D'Onofrio G., Nabavi S.F. (eds) Nutrients and Nutraceuticals for Active & Healthy Ageing, Springer Singapore, Singapore

Year : 2020

Epidermal Growth Factor Receptor (EGFR): Promising targets for Non-Small Cell Lung Cancer

Cite this Research Publication : P. DGT, KM, N., MS, U., and Bijo Mathew, “Epidermal Growth Factor Receptor (EGFR): Promising targets for Non-Small Cell Lung Cancer”, Springer Publishers, 2020, pp. 465-471.

Publisher : Springer Publishers

Year : 2020

Neurochemicals in Nervous System and Exploring the Chemical Make-Up of Human Brain

Cite this Research Publication : S. Harilal, Kumar, R., Mathew, G. Elizabeth, Jose, J., Uddin, M. Sahab, and Bijo Mathew, “Neurochemicals in Nervous System and Exploring the Chemical Make-Up of Human Brain”, in Principles of Neurochemistry: Fundamentals and Applications, B. Mathew and Parambi, D. Grace Thom, Eds. Singapore: Springer Singapore, 2020, pp. 19 - 39.

Publisher : Springer Singapore, Singapore

Year : 2020

Epidermal Growth Factor Receptor (EGFR): Promising targets for Non-Small Cell Lung Cance

Cite this Research Publication : P. DGT, KM, N., MS, U., and Bijo Mathew, “Epidermal Growth Factor Receptor (EGFR): Promising targets for Non-Small Cell Lung Cancer”, Springer Publishers, 2020, pp. 465-471.

Publisher : Springer Publishers

Year : 2020

Neurochemicals in Nervous System and Exploring the Chemical Make-Up of Human Brain

Cite this Research Publication : S. Harilal, Kumar, R., Mathew, G. Elizabeth, Jose, J., Uddin, M. Sahab, and Bijo Mathew, “Neurochemicals in Nervous System and Exploring the Chemical Make-Up of Human Brain”, in Principles of Neurochemistry: Fundamentals and Applications, B. Mathew and Parambi, D. Grace Thom, Eds. Singapore: Springer Singapore, 2020, pp. 19 - 39.

Publisher : Principles of Neurochemistry: Fundamentals and Applications

Year : 2017

The Search for Novel Antidepressants: An Integrative View to Drug Discovery- Chapter-5- Monoamine Oxidase-A: A Valid Target for the Management of Depression

Cite this Research Publication : Bijo Mathew and Suresh, J., “The Search for Novel Antidepressants: An Integrative View to Drug Discovery- Chapter-5- Monoamine Oxidase-A: A Valid Target for the Management of Depression”, vol. 2, BenthamScience Publisher, 2017, pp. 132-140.

Publisher : BenthamScience Publisher

Patents

Year : 2020

Protective or therapeutic compositions of neurological disorders containing furano chalcones as effective agents

Cite this Research Publication : S. J., C., B. S., S.P., R., H., K., and Bijo Mathew, “Protective or therapeutic compositions of neurological disorders containing furano chalcones as effective agents”, 2020.

Year : 2020

Composition for preventing or treating ethyl acetohydroxmate incorporated chalcones as an active ingredient

Cite this Research Publication : K. H., S.C., B., P., L. J., Bijo Mathew, TM, R., and Reeta, “Composition for preventing or treating ethyl acetohydroxmate incorporated chalcones as an active ingredient”, 2020.

Publisher : Patent file no:10-2020-0054743 [Korean Intellectual Property of Office (KIPO)]

Book

Year : 2021

Medicinal Chemistry –II

Cite this Research Publication : D. Manjinder Singh and Bijo Mathew, Medicinal Chemistry –II. eReadOn (Doonville Publishers (P) Ltd), 2021.

Publisher : Doonville Publishers (P) Ltd

Year : 2020

Principles of Neurochemistry Fundamentals and Applications

Cite this Research Publication : Bijo Mathew and Parambi, D., Principles of Neurochemistry Fundamentals and Applications. 2020.

Teaching Experience
Year Affiliation
Present Associate Professor, Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Kochi, India.
November 11, 2015 – October 31, 2020 Associate Professor, Ahalia School of Pharmacy, Palakkad, India.
Subjects Taught:
– Pharmaceutical Organic Chemistry (B. Pharm.)
– Medicinal Chemistry (B. Pharm.)
November 23, 2009 – October 31, 2015 Assistant Professor, Grace College of Pharmacy, Palakkad, India.
Subjects Taught:
– Pharmaceutical Organic Chemistry (B. Pharm.)
– Medicinal Chemistry (B. Pharm.)
– Advanced Medicinal Chemistry (M. Pharm.)
August 18, 2008 – July 29, 2009 Lecturer, Nehru College of Pharmacy, Thrissur, India.
Subjects Taught:
– Pharmaceutical Organic Chemistry
– Medicinal Chemistry
Workshops and Trainings Attended
No. Area Venue Duration
1. Computer-aided drug design seminar and hands-on training of GLIDE software College of Pharmacy, Madras Medical College, Chennai, India. January 4-5, 2011
2. Course Work on “Research Methodology  J.N.T.U. Hyderabad, India. June 6-11, 2011
3. National  workshop on NMR spectroscopy: Theory, Principle and instrumentation  IIRBS Mahatma Gandhi University, Kottayam, India. September 10-13, 2014
4. Role of Indian Regulators and Pharma Industry 66th Indian Pharmaceutical Congress-Hyderabad, India. January 23-25-, 2015
Invited Talks
International Level
No. Topic Year and Venue
1. Chalcone chemistry towards monoamine oxidase enzyme inhibition: Development of new class of Anti-Alzheimer’s agents July 1, 2019 – International Multidisciplinary Symposium on Drug Research and Development-Inonu University-Malatya-Turkey
National Level
No. Topic Year and Venue
1. Extraction of Phytochemicals and their Importance 2009 – Nehru College of Pharmacy, Thrissur, Kerala, India.
2. Utilization of Open-source Software for the Drug Discovery Process 2013 – College of Pharmacy, Madras Medical College, Chennai, India.
3. Utilization of Computational Tools in Drug Discovery August 24, 2013 – Jamia Salifia Pharmacy College, Pulikal, Kerala, India.
4. Drug Receptor Interaction and Hands-on Training of AutoDock4.2. and its Interpretation January 31, 2014 – College of Pharmacy, Madras Medical College, Chennai, India.
5. Workshop on Docking Studies of Synthetic Molecules April 3, 2014 – Devaki Amma Memorial College of Pharmacy, Malappuram, Kerala, India.
6. Basic Principles of Drug Design and QSAR Approach April 28, 2015 – Moulana College of Pharmacy, Perinthelmanna, Kerala, India.
7. Rational Approaches of Drug Design and Introduction of CADD February 20, 2016 – Malik Deenar College of Pharmacy, Kasaragod, Kerala, India.
8. Workshop on the Design and Docking Studies of MAO Inhibitors (AutoDock Tools) June 25, 2016 – College of Pharmacy, Madras Medical College, Chennai, India.
9. Introduction to Drug Design and Drug Development October 19, 2016  – National College of Pharmacy, Calicut, Kerala, India.
10. Integrated View of Structure-based Drug Design of Newer Molecules November 18, 2016 – Karpagam University, Coimbatore, India.
11. Principles of Drug Design and Introduction of CADD November 25, 2017 – Srikrishna College of Pharmacy, Trivandrum
12. Relevance of Molecular Docking in Drug Design December 17, 2017 – National College of Pharmacy, Calicut, Kerala, India.
13. Workshop on the Docking Studies of MAO-B Inhibitors (AutoDock Tools) January 20, 2018 – National College of Pharmacy, Calicut, Kerala, India.
14. Seminar cum Workshop on the Docking Studies of (AutoDock Tools) February 24, 2018 – KVM College of Pharmacy, Cherthala, Kerala, India.
15. Seminar cum Workshop on the Docking Studies of (AutoDock Tools) February 22, 2019 – Devaki Amma Memorial College of Pharmacy, Malappuram, Kerala, India.
16. An Overview on Molecular Docking and QSAR Febraury 23, 2019 – Swamy Vivekanda College of Pharmacy, Tamilnadu, India.
17. Introduction of Drug Design and Protein Target Prediction October 19, 2019 – College of Pharmacy, Madras Medical College, Chennai, India.
18. Seminar cum Workshop on AutoDock based Drug Design October 26, 2019 – Nirmala College of Pharmacy, Muvatupuzha, Kerala India.
19. Perspectives of Drug Design Project in an Academic Scenario: Where We Stand Now & What We Can Do? November 2, 2019 – National College of Pharmacy, Calicut, Kerala, India.
20. Ligand-based Drug Design Special Emphasis with 2D and 3D QSAR December 10, 2019 – Thanthai Rover college of Pharmacy, Perambalur, Tamilnadu, India.
21. Research Methodology: A Process from Literature Review to Thesis Writing January 18, 2020 – National College of Pharmacy, Calicut, Kerala, India
22. Drug Design Principles and Molecular Docking Techniques June 5, 2020 – Vinayaka Mission’s College of Pharmacy, Salem, Tamilnadu, India.
23. Drug Reposition: Transformation on Hard Work to Mart Work August 22, 2020 – Nirmala College of Pharmacy, Muvatupuzha, Kerala India.
24. Over-view of drug receptor interactions 31-5-2021 & National Webinar organised by Dr. M.G.R. Educational and Research Institute , Chennai, India.
25. Research Methodology 11-06-2021 & the National Webinar organised by Vinayaka Mission’s University, Salem, India.
26. Writing techniques of a medicinal chemistry research paper in a peer-reviewed journal 31-05-2021 & the National FDP AICTE Sponsored Program organised by National College of Pharmacy, Calicut, India.
International and National Collaborative Research Program Carried out
  1. National Institute of Neurological Disorders and Syndrome (NINDS), National Institute ofHealth (NIH), Bethesda, MD 20892-9020, USA.
  2. Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Sýhhiye 06100, Ankara, Turkey. (WithProf. Dr. G. Uçar).
  3. Department of pharmacy and research institute of life Pharmaceutical Sciences, Sunchon National University, Suncheon 579922, Republic of Korea (Prof. Dr. Hoon Kim)
  4. Laboratory of Molecular & Cellular Biology, Department of Biological Chemistry-IQUIBICEN, Natural Exact Sciences School, University City,University of Buenos Aires, Buenos Aires (C1428EGA),Argentina. (WithProf. Dr. M. D. Galigniana).
  5. School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4001, South Africa.(WithProf. Dr. M. E. S. Soliman).
  6. Department of Pharmaceutical Chemistry and Centre of Excellence for Pharmaceutical Sciences, School of Pharmacy, North-West University, Private Bag X6001,Potchefstroom 2520,South Africa.(WithProf. Dr. J.P. Petzer).
  7. Universidade Federal Rural do Rio de Janeiro, Departmento de Quimica. Brazil
  8. Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy (WithProf. Dr. S. Carradori).
Professional Recognition as an Examiner for Ph.D. & P.G.
  1. “Design, Synthesis and evaluation of new chemical scaffolds as potential anti-cancer agents” by Ms. M. Bhagyalalitha2019 (External Expert in Ph.D.). JSS Academy of Higher Education and Research(Deemed to be University). Mysuru, India.
  2. Doctor of Philosophy Thesis evaluator2017. (International Evaluator) of‘The dual role of cathepsin-d in breast cancer and hiv neuropathogenesis’by O.A. Arodola (Reg No:213569288) under the supervision of Prof. M.E.S. Soliman [School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4001, South Africa.]
  3. Doctor of Philosophy Thesis evaluator2017. (International Evaluator) of‘Application of advanced computational tools towards the understanding of TB targets and design of potential drug candidates’by Kgothatso E. Machaba (Reg No:215082344) under the supervision of Prof. M.E.S. Soliman [School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4001, South Africa.]
  4. Post Graduate Thesis evaluator2017. (International Evaluator) of‘Designing of novel HIV/TB Inhibitors Using In silico Drug Design Approaches’ by Lauren Blake (Reg No: 21357002) under the supervision of Prof. M.E.S. Soliman [School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4001, South Africa.]
Research Fund of Sponsored Projects

International Level Minor

  • Design of new class of halogenated cinnamoyl derivatives as selective monoamine oxidase –B inhibitors by similarity based drug design. [International consultant] Deanship of scientific research (DSR), King Khalid University, Abha, Kingdom of Saudi Arabia. 20000 S.R. [2020]. Project No: 23/1441. Completed.
  • Design, synthesis of Sulphur and nitrogen containing α-β- unsaturated ketones as a new multitarget ligands for the treatment of Alzheimer’s disease.’ [Co-Investigator] Deanship of scientific research (DSR), King Khalid University, Abha, Kingdom of Saudi Arabia. 20000 S.R. [2021]. Project No: 159/42. Ongoing.

National Level Minor

  • Development of Multi-conjugated ketones as the development of new class of dual acting MAO/AChE inhibitors for the treatment of Alzheimer’s disease. [Principal Investigator] [Amrita Vishwa Vidyapeetham, Kochi, India, Seed Grant- 5 Lakhs [2020]. Grant Number K‐PHAR‐20‐628]. Ongoing.
  • Development and fine-tuning of methoxylated α,β-unsaturated ketones as monoamine oxidase inhibitors. Synthesis, biochemistry and computational study. [Principal Investigator] [Kerala State Council for Science, Technology & Environment – 10000 Rs. [2016].File No: 1/SPS-59/2016/CSTE. Completed.
  • Synthesis, in silico design and anticonvulsant screening of some novel thiophene based hydrazone derivatives. [Principal Investigator] [Kerala State Council for Science, Technology & Environment – 10000 Rs. [2014].File No: 77/SPS-52/2014/CSTE. Completed.
  • Development of some new trans-1, 3- substituted diphenyl-2-propen-1-ones as Monoamine Oxidases Inhibitors: An in vitro and in vivo study. [Co- Investigator] [Kerala State Council for Science, Technology & Environment – 10000 Rs. [2015].File No: 01/SPS-54/2015/CSTE. Completed.
Honorarium Received

Honorarium Received

  • Received 400 US dollars in connection with the Guest Editor of the journal ofCentral Nervous System Agents in Medicinal Chemistry [BenthamScience]. Cheque no: 179832121 (Dated 2016 July 31).
  • Received 600 US dollars in connection with the Guest Editor of the journal of Combinatorial Chemistry and High throughput Screening [Bentham Science]. Cheque no: 179832121 (Dated 2021 February 16).

Awards Received

  • Dr. Bijo Mathew Among World’s Top 2% Scientists of Stanford’s List (Based on citations, h-index and co-authorship from scopus)
    The US-based prestigious Stanford University has recently released a list, that represents the top 2 percent of the most-cited scientists in various disciplines. They have created a publicly available database of over 100,000 top-scientists that provides standardized information on citations, h-index, co-authorship adjusted hm-index, citations to papers in different authorship positions and a composite indicator. Scientists are classified into 22 scientific fields and 176 sub-fields and the career-long data are updated to end-of-2020 . Dr. Bijo Mathew is listed among the top in the field of Chemistry under Neurology. He holds one international Patent, over 161 publications, 2328 scopus citations and h-index 30 to his credit. His research interest is to design and synthesis novel molecules from various heterocyclic nuclei such as benzimidazole, thiadiazole, pyrimidine, furan, pyrazoline and thiazole for the treatment of neurodegenerative disorders.
  • Amrita Innovation and Research Awards: [2021] Received Chancellor’s Publication Award
  • Amrita Innovation and Research Awards: [2021] Received Publication Merit award.
  • Received Best Resource Person award in 2021 at National College of Pharmacy in AICTE and learning (ATAL) academy sponsored FDP program

Research Publication

  • Scopus ID: 3700005470
  • Researcher ID is: G-7477-2014
  • Scopus citation: 2128
  • H-index: 29 [Scopus]
  • Google scholar citation: 2517
  • H-index: 31 [Google scholar]
  • i10-index: 74 [Google scholar]
Cumulative Impact Factor: 434.38 [Based on 2021 JCR reports]
NO Journal Title Publisher Impact factor No. of papers
1 Science of the Total Environment Elsevier 7.96 2
2 Current Neuropharmacology Bentham 7.36 1
3 International Journal of Biological Macromolecules Elsevier 6.95 3
4 Oxidative Medicine and Cellular Longevity Hindawi 6.54 2
5 Biomedicine and Pharmacotherapy Elsevier 6.52 1
6 European Journal of Medicinal Chemistry Elsevier 6.51 3
7 Pharmaceutics MDPI 6.30 1
8 Journal of Molecular liquids Elsevier 6.16 2
9 International Journal of Molecular Science MDPI 5.92 1
10 Pharmaceuticals MDPI 5.86 2
11 Molecular Neurobiology Springer 5.50 3
12 Bioorganic Chemistry Elsevier 5.27 2
13 Neural Regeneration Research Medknow 5.13 1
14 Journal of Enzyme Inhibition and Medicinal Chemistry Tailor and Francis 5.05 2
15 Life Science Elsevier 5.03 1
16 Current Medicinal Chemistry Bentham 4.53 3
17 Molecules MDPI 4.41 4
18 CNS and Neurological Disorders and Drug Targets Bentham 4.40 2
19 Environmental Science and Pollution Research Springer 4.22 6
20 Drug Design Development Therapy Dove Press 4.16 1
21 Brain Research Bulletin Elsevier 4.07 1
22 Excli Journal University of Mainz 4.06 1
23 Neurochemical Research Springer 3.99 1
24 Journal of Saudi Chemical Society Elsevier 3.93 2
25 Neurotoxicity Research Springer 3.91 1
26 ACS Combinatorial Science ACS 3.78 1
27 Journal of Pharmacy and Pharmacology Wiley 3.76 3
28 Process  Biochemistry Elsevier 3.76 1
29 Archiv de Pharmazie Wiley 3.75 4
30 MedChemCommun [RSC Medicinal Chemistry] RSC 3.59 1
31 Journal of Biomaterial Research Part A Wiley 3.52 1
32 ACS OMEGA ACS 3.51 1
33 Current Drug Targets Bentham 3.46 3
34 ChemMedChem Wiley 3.46 4
35 Current Topics in Medicinal Chemistry Bentham 3.29 2
36 Current Protein and Peptide Science Bentham 3.27 1
37 IUMB life Wiley 3.24 1
38 Journal of Molecular Structure Elsevier 3.19 4
39 Journal of Neurological Sciences Elsevier 3.18 1
40 Current Pharmaceutical Design Bentham 3.11 7
41 Journal of Physical Chemistry B ACS 2.99 1
42 Chemical Biology and Drug Design Wiley 2.81 1
43 Immunopharmacology and  Immunotoxicology Tailor and Francis 2.73 1
44 Applied Sciences MDPI 2.67 1
45 Evidence based Complementary and Alternative Medicine Hindawi 2.62 1
46 Mini Reviews in Organic Chemistry Bentham 2.49 1
47 Chemistry and Biodiversity Wiley 2.40 1
48 ChemistrySelect Wiley 2.10 7
49 Medicinal Chemistry Research Springer 1.96 1
50 Combinatorial Chemistry and High Throughput Screening Bentham 1.33 8
51 Acta Crystallographica Section C Wiley 1.17 1
52 Letters in Drug Design and Discovery Bentham 1.15 3
53 Indian Journal of Pharmaceutical Sciences MedKnow 0.97 2
54 Bangladesh Journal of Pharmacology BPS 0.93 1
55 Letters in Organic Chemistry Bentham 0.86 1
56 Indian Journal of Heterocyclic Chemistry NACB-India 0.34 1
Category Number of Papers Published
First Author cum Corresponding Author: 58
Corresponding Author 117
Co-Author 40
Single-Author: 2
Total 157
Admissions Apply Now