Publications

Publication Type: Journal Article

Year of Conference Publication Type Title

2018

Journal Article

C. Porayath, Suresh, M. K., Dr. Raja Biswas, Dr. Bipin G. Nair, Dr. Nandita Mishra, and Dr. Sanjay Pal, “Autolysin Mediated Adherence of Staphylococcus Aureus with Fibronectin, Gelatin and Heparin”, International Journal of Biological Macromolecules, 2018.

2018

Journal Article

Pandurangan Nanjan, Chinch Bose, M. Sreejith, Veni C K, Anjana M Amrita, and Anjana R P., “Synthesis, bioactivities and in-silico docking studies of azaleatin-a quercetin partial methyl ether; SAR study.”, vol. 14, 2018.[Abstract]


Azaleatin- a lesser known partially methylated flavonoid, has been synthesized efficiently through MOM protection and deprotections from quercetin. The synthesized compound and closely related partially methylated flavonoids (SAR) were subjected for the investigation of α-amylase and antioxidant activities. Among the compounds tested, azaleatin was found to be best inhibitor for α-amylase with acceptable radical scavenging activity than closely related compounds. Further, in-silico modelling studies indicated that azaleatin forms hydrogen bonds with the key amino acid residues such as Gln63, Arg195 and Asp197 of α-amylase receptor. Acarbose was used as positive control for α-amylase inhibition.

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2017

Journal Article

Chandni P, Amrita Salim, Archana P. V., Pradeesh Babu, Dr. Bipin G. Nair, Madhavan, A., and Dr. Sanjay Pal, “Characterization of the bacteriophages binding to human matrix molecules.”, International Journal of Biological Macromolecules, 2017.[Abstract]


Recent literature has suggested a novel symbiotic relationship between bacteriophage and metazoan host that provides antimicrobial defense protecting mucosal surface by binding to host matrix mucin glycoproteins. Here, we isolated and studied different bacteriophages that specifically interact with human extracellular matrix molecules such as fibronectin, gelatin, heparin and demonstrated their potency for protection to host against microbial infections. We showed that subpopulations of bacteriophages that work against clinical isolates of Escherichia coli can bind to pure gelatin, fibronectin and heparin and reduced bacterial load in human colon cell line HT29. The bacteriophages were characterized with respect to their genome sizes, melting curve patterns and host tropism (cross-reactivity with different hosts). Since, the bacteriophages are non-toxic to the host and can effectively reduce bacterial load in HT29 cell line their therapeutic potency against bacterial infection could be explored.

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Publication Type: Conference Paper

Year of Conference Publication Type Title

2017

Conference Paper

V. Amrutha., Prasad Megha, Lekshmija, A., Anjana, R., Aleena, S., Dr. Bipin G. Nair, Madhavan, A., and Dr. Sanjay Pal, “Effect of compost derived lytic agents against enteric bacteria in sewage”, in InnovativeStrategies for Sustainable Water Management (ISSWM-2017), Punjab, India. , 2017.

2017

Conference Paper

Pradeesh Babu, Poornendu, S. J., Amrita Salim, Madhavan, A., Dr. Bipin G. Nair, and Dr. Sanjay Pal, “Resazurin based redox dye as an indicator for monitoring wastewater biological activity”, in Innovative Strategies for Sustainable Water Management (ISSWM-2017), Punjab, India, 2017.

2017

Conference Paper

M. Sreejith, Reghu, A. P., Anandakrishnan, K., Gopika, P. J., .Kuriakose, G., Reshma, M. J., Vishnu, K., Madhavan, A., Dr. Bipin G. Nair, and Dr. Sanjay Pal, “Screening potential antimicrobial compounds by resazurin dye based viability assay”, in Innovative Strategies for Sustainable Water Management (ISSWM-2017), Punjab, India, 2017.

2017

Conference Paper

V. Prakash, H. Sreetha, Poornima, K. H., Lakshmimol, K. N., Regma, R., Fathima, H., Vishnu, T. V., Venu, S., Dr. Bipin G. Nair, and Dr. Sanjay Pal, “Antagonistic effects of bacteriocins from Lactobacillus spp. against enteric pathogens”, in Innovative Strategies for Sustainable Water Management (ISSWM-2017), Punjab, India ., 2017.

2017

Conference Paper

S. Subhash, Kuruvelil, A. B., Aswathi, P. V., Deepasree, K., Navyamol, C. D., N.P.V., D., Prasad, P., Dr. Bipin G. Nair, and Dr. Sanjay Pal, “Screening of nematicidal activities of biocontrol fungi Aspergillus niger and Penicillium oxalicum using C. elegans as model”, in Innovative Strategies for Sustainable Water Management (ISSWM-2017) , Punjab, India. , 2017.

2017

Conference Paper

D. Tharuvana, A. Sundaresh, Sreelakshmi, V. J., Das, A., Dr. Bipin G. Nair, Dr. Sanjay Pal, and Madhavan, A., “Sand and charcoal as matrices for immobilization of phages for wastewater treatment”, in Innovative Strategies for Sustainable Water Management (ISSWM-2017) , Punjab, India. , 2017.

2017

Conference Paper

A. P. Veedu, Reshma, R. N., Dr. Bipin G. Nair, Dr. Sanjay Pal, and Madhavan, A., “Activity of probiotic strains against enteric pathogens”, in Innovative Strategies for Sustainable Water Management (ISSWM-2017) , Punjab,India. , 2017.

2017

Conference Paper

A. Madhavan, Prasad Megha, Girish, S., K. Shetty, S., Dr. Bipin G. Nair, and Dr. Sanjay Pal, “Caulobacter crescentus as a novel exoelectricigen in a dual chambered Microbial Fuel Cell (MFC)”, in Technical Program Committee of the “2017 IEEE International( Biennial) Conference on Technological Advancements in Power and Energy”, TAP Energy-2017. , 2017.

2017

Conference Paper

A. Madhavan, K. Shetty, S., Anjana, G., Das, A., Athira, A. S., Hari, H., ,, Babu, S., Dr. Bipin G. Nair, and Dr. Sanjay Pal, “Pneumatophore inspired biomimetic approach to design an energy neutral aerator for application in composting”, in Technical Program Committee of the “2017 IEEE International ( Biennial) Conference on Technological Advancements in Power and Energy”, TAP Energy-2017. , 2017.

2017

Conference Paper

P. Nagarajan, Sruthy, K. S., Lal, V. P., Devan, V. P., Krishna, A., Lakshman, A., Vineetha, K. M., Dr. Bipin G. Nair, Dr. Sanjay Pal, and Madhavan, A., “Biological treatment of domestic wastewater by selected aquatic plants”, in IEEE International Conference on Technological Advancements in Power & Energy (TAP Energy 2017). , 2017.[Abstract]


Around 30 percent of the operating costs of conventional centralized wastewater treatment is required for energy to operate the machines for pump and aeration. Comparatively, constructed wetlands involving photosynthetic plants and other organisms have a lower energy requirement. The aim of the present work is to select aquatic plants which have high efficiency of removing infection in wastewater. Four plants were chosen from locally available plants growing in wastewater. They were put in raw wastewater from toilets for 24 h and were tested for their survival and growth measured by chlorophyll content. Brahmi (Bacopa monnieri) and Duckweed were found to be best compared to Azolla and Hydrilla. The efficiency of removal of enteric infections was done by culturing the treated wastewater on Eosin Methylene Blue (EMB) agar media, a selective and differential medium for enteric gram negative bacteria. The best performing plants were Brahmi and Hydrilla which reduced the load by 67-70%. But Hydrilla did not grow as well compared to Brahmi as evident from the chlorophyll content. Hence Brahmi and Duckweed can be considered as most effective for removal of infection in wastewater among the four tested plants and potentially may save energy and synthetic chemicals otherwise required for conventional treatment systems. Brahmi, famous for its high value medicinal compounds against neuronal problems, may be used for extraction of the compounds. The remaining biomass can be used as feedstock in anaerobic digester for methane/ethanol generation to be used as biofuel.

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2016

Conference Paper

A. Madhavan, Nandakumar, V., K. Shetty, S., Dr. Bipin G. Nair, and Dr. Sanjay Pal, “Optimization of microbial fuel cell (MFC) operated with waste water as substrate”, in Electrical, Electronics, and Optimization Techniques (ICEEOT), International Conference on, Chennai, India, 2016.[Abstract]


In the present study bioelectricity generation from waste water was evaluated in a double chambered microbial fuel cell (MFC). Waste water and potassium permanganate solution (0.3%) was loaded in the anodic and the cathodic chamber respectively. The performance of MFC was studied with two different electrodes (aluminum and carbon as anodes and copper as cathode). Current and voltage measurements were carried out using Keithley source meter (2420) and multimeter respectively. The Voltammetric analysis was done to study the anodic oxidation rate. The resistance of the system was found to be low (0.466 Ω for the aluminum anode and 0.673 Ω carbon anode) which were deduced from the power density curves. The system showed a COD removal of 77% over a period of a week ofk operation.

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Publication Type: Conference Proceedings

Year of Conference Publication Type Title

2015

Conference Proceedings

Vijayakumar Amrutha, Chinchu, B., Nanjan Pandurangan, Dr. Sanjay Pal, G. Bipin, N., Ajith, M., and Salim Amrita, “Potent chitin Synthase inhibitors from Plant sources”, Proceeding of National seminar on Recent advances in medicinal plant research. Bharat mata college , 2015.

2015

Conference Proceedings

Salim Amrita, Ugesh, k.p., Chandni, P., Sreerangini, M. R., Bipin, N., Ajith, M., Dr. Sanjay Pal, and Sreetha, H., “Isolation and characterization of bacteriophage treatment of domestic wastewater”, Proceeding of the 56th International Annual Conference of The Association of Microbiologist of India . JNU, New Delhi, 2015.

2015

Conference Proceedings

C. P., P., B., N., M., V., A., C., N., G., V., S., S., A., M., B.G., N., N., M., and Dr. Sanjay Pal, “Transformation, expression and activity analysis of recombinant Staphylococcus autolysin in Bacillus”, The 39th All India Cell Biology Conference on “Cellular Organization and Dynamics", Thiruvananthapuram, Kerala, India, . Thiruvananthapuram, Kerala, India, 2015.

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