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Dr. Jayakumar Rangasamy

Professor

Dr. Jayakumar Rangasamy, Professor, Polymeric Biomaterials group, ACNSMM

Qualification: Ph.D
rjayakumar@aims.amrita.edu

Bio

Dr. R. Jayakumar is a Professor at the Centre for Nanosciences and Molecular Medicine (ACNSMM), Amrita Vishwa Vidyapeetham, specializing in the area of Biomaterials for Healthcare Applications. Dr. R. Jayakumar joined ACNSMM in November 2007. He received his Ph.D. in Polymer Chemistry from Anna University, Chennai, India (2002). Dr. Jayakumar’s research laboratory at ACNSMM focuses on development of biodegradable polymeric nanofibers, nanogels, nanoparticles, nanocomposite scaffolds and injectable hydrogels for Tissue Engineering, Drug Delivery, and Wound Dressing applications.

Dr. Jayakumar’s academic achievements include third rank in M. Sc. from Bharathidasan University, Senior Research Fellowship from the Council of Scientific and Industrial Research (CSIR), Govt. of India (2001), University Postdoctoral Fellowship from Chonbuk National University (2002-2003), South Korea, and FCT Postdoctoral Fellowship from the Government of Portugal (2003-2005). Dr. Jayakumar was also awarded the prestigious JSPS Postdoctoral Fellowship (2005-2007) from the Japan Society for the Promotion of Science (JSPS), Japan. Dr. Jayakumar has over 240 Journal publications, 4 books, 12 book chapters, and 10 filed patents to his credit. His publications have been cited more than 14100 times with h-index-62. Dr. Jayakumar is also the recipient of several other awards like Best Paper Award from Journal of Materials Science Materials in Medicine (Springer) and IET Nanobiotechnology Journal, Faculty Researcher Award – 2016 from Indian Chitin and Chitosan Society (ICCS), India,the very prestigious MRSI Medal-2017 from Materials Research Society of India (MRSI, and the India Research Excellence-Citation Awards-2017 (Health & Medical Science area) from Clarivate Analytics, Web of Science. Dr. Jayakumar is a reviewer and editorial board member of many international journals. Dr. Jayakumar has completed more than 17 funded projects and is currently involved with 4 ongoing projects. He has active collaborations with many research groups in USA, Japan, South Korea, Portugal, and Taiwan.

Research

The Lab key focus is on understanding and designing biomaterials using biomimetic approach for tissue regeneration. Our research interests are development of injectable hydrogels, electrospun scaffolds and scaffolds for wound healing.

Injectable Hydrogels

The desire and need to minimize traditional open surgeries is gearing up as it could reduce the healthcare expenses and improve the recovery time for the patients. Injectable hydrogels with their ease of handling, complete filling of the defect area and good permeability have emerged as promising biomaterials. The Jayakumar group designs shear thinning injectable hydrogel and in situ cross-linked hydrogel with bio-inspired polymers and nanoparticles for tissue regeneration. Injectable hydrogels are designed for effective regeneration of functional tissue, such as bone, fat, and cartilage. Further, work is also been directed towards achieving therapeutic angiogenesis in order to revascularize ischemic tissues and in developing cost effective injectable hydrogel and bioadhesive hydrogel for haemostatic applications. Bioadhesive hydrogel loaded with antibacterial drug is being developed for treating mediastinitis.

Electrospun Scaffolds

Electrospun fibres’ possess unique properties promise to make key bioengineered material for tissue regeneration. We fabricate fibres in different 3-D forms so as to make layered tubular constructs, thick layered fibrous scaffolds, braided and rolled fibre scaffolds. The Jayakumar group is developing approaches to control cell differentiation through surface modification of electrospun fibres. Further, work is also directed towards designing scaffolds for tendon and ligament regeneration using electrospun fibre scaffold.

Wound Healing

Natural process of wound healing is impaired in many pathological conditions, resulting in chronic wounds. Pathological conditions arising as of diabetic conditions, hyperfibrinolytic conditions, polymicrobial infection, burn wounds etc are create different complications in the treatment for wound healing. The underlying pathology in these conditions is not fully understood. The Jayakumar group in developing bandages in addressing in the problems in the above mentioned situations

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Publications

Book

Chitosan for Biomaterials III Structure-Property Relationships

Authors : Dr. Jayakumar Rangasamy, Prabaharan Mani

Publisher : Advances in Polymer Science

Journal Article

Preface, Chitosan for Biomaterials IV: Biomedical Applications

Authors : Dr. Jayakumar Rangasamy, Prabaharan Mani

Publisher : Advances in Polymer Science

Chitosan Based Biomaterials for Periodontal Therapy

Authors : Dr. Jayakumar Rangasamy, Arun Kumar Rajendran

Publisher : Springer International Publishing

Perspectives and Challenges of Using Chitosan in Various Biological Applications

Authors : Dr. Jayakumar Rangasamy, Sivashanmugam Amirthalingam; Arun Kumar Rajendran; Prabaharan Mani

Publisher : Advances in Polymer Science

Chitosan-Based Biosensor Fabrication and Biosensing Applications

Authors : Dr. Jayakumar Rangasamy, Sivashanmugam Amirthalingam;

Publisher : Advances in Polymer Science

Synthesis-Structure Relationship of Chitosan Based Hydrogels

Authors : Dr. Jayakumar Rangasamy, Nivethitha Ashok; Aathira Pradeep

Publisher : Advances in Polymer Science

In-situ silver nanoparticles incorporated N, O-carboxymethyl chitosan based adhesive, self-healing, conductive, antibacterial and anti-biofilm hydrogel.

Authors : Dr. Jayakumar Rangasamy, Mahalakshmi Pandian;Vignesh Selvaprithviraj; Aathira Pradeep

Publisher : International Journal of Biological Macromolecules

Prospection of chitosan and its derivatives in wound healing: Proof of patent analysis (2010–2020)

Authors : Dr. Jayakumar Rangasamy, Pradeep Shivakumar; Maram Suresh Gupta; Devegowda Vishakante Gowda

Publisher : International Journal of Biological Macromolecules

Addition of lactoferrin and substance P in a chitin/PLGA-CaSO4 hydrogel for regeneration of calvarial bone defects

Authors : Dr. Jayakumar Rangasamy, Sivashanmugam Amirthalingam; Seunghun S. Lee; Arun Kumar Rajendran;Inseon Kim; Nathaniel S. Hwang

Publisher : Materials Science and Engineering C

Hydrogels: A potential platform for induced pluripotent stem cell culture and differentiation

Authors : Dr. Jayakumar Rangasamy, Dr. Ullas Mony, M. R. Poorna; Jyh -PingChen

Publisher : Colloids and Surfaces B: Biointerfaces

Combinatorial effect of nano whitlockite/nano bioglass with FGF-18 in an injectable hydrogel for craniofacial bone regeneration

Authors : Dr. Subramania Iyer K., Dr. Jayakumar Rangasamy, Sivashanmugam Amirthalingam; Seunghun S. Lee; Mahalakshmi Pandian; Janarthanan Ramu; Nathaniel S. Hwang

Publisher : Biomaterials Science

Synthesis, Characterization and Cytocompatibility Studies of α-chitin Hydrogel/nano Hydroxyapatite Composite Scaffolds

Authors : Dr. Sowmya Srinivasan, Dr. Jayakumar Rangasamy, Kumar, P.T.S.; Sowmya Srinivasan; Lakshmanan, V.-K.; Tamura, H.; Nair, S.V.; Dr. Jayakumar Rangasamy

Publisher : International Journal of Biological Macromolecules

Tetracycline Nanoparticles Loaded Calcium Sulfate Composite Beads for Periodontal Management

Authors : Dr. Raja Biswas, Dr. Sowmya Srinivasan, Dr. Jayakumar Rangasamy, Sindhura Reddy, N.; Bumgardner, J.D.; Chennazhi, K.P.

Publisher : Biochimica et Biophysica Acta - General Subjects

Chitin and Chitosan in Selected BiomedicalApplications

Authors : Dr. Sowmya Srinivasan, Dr. Jayakumar Rangasamy, Anitha, A.; Kumar, P.T.S.; Deepthi, S.; Chennazhi, K.P.; Ehrlich, H.; Tsurkan, M.

Publisher : Progress in Polymer Science

Pro-angiogenic Molecules for Therapeutic Angiogenesis.

Authors : Dr. Jayakumar Rangasamy, Dr. Sowmya Srinivasan, Selvaprithviraj, Vignesh; Sankar, Deepthi; Sivashanmugam, Amirthalingam

Publisher : Curr Med Chem

Role of Nanostructured Biopolymers and Bioceramics in Enamel, Dentin and Periodontal Tissue Regeneration

Authors : Dr. Sowmya Srinivasan, Dr. Jayakumar Rangasamy, Bumgardener, J.D.; Chennazhi, K.P.; Nair, S.V.

Publisher : Progress in Polymer Science

Electrospinning of biocompatible polymers and their potentials in biomedical applications

Authors : Dr. Jayakumar Rangasamy, Dr. Sowmya Srinivasan, Supaphol, P.; Suwantong, O.; Sangsanoh, P.; Nair, S.V.

Publisher : Advances in Polymer Science

Curcumin Loaded Chitin Nanogels for Skin Cancer Treatment via the Transdermal Route

Authors : Dr. Jayakumar Rangasamy, Dr. Sabitha M., Prof. Shantikumar Nair, S. Mangalathillam, Rejinold, N. S., Nair, A., Lakshmanan, V. - K., Shantikumar V Nair

Publisher : Nanoscale

Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration

Authors : Dr. Jayakumar Rangasamy, Prof. Shantikumar Nair, Dr. Sowmya Srinivasan, Sowmya Srinivasan; Jayasree, R.; Chennazhi, K.P.; Shantikumar V. Nair; Dr. Jayakumar Rangasamy

Publisher : Carbohydrate Polymers

Synthesis, Characterization and in vitro Cytocompatibility Studies of Chitin Nanogels for Biomedical Applications

Authors : Dr. Sabitha M., Dr. Jayakumar Rangasamy, S. N. Rejinold, Nair, A., Chennazhi, K. P., Tamura, H., Nair, S. V

Publisher : Carbohydrate Polymers

Effect of incorporation of nanoscale bioactive glass and hydroxyapatite in PCL/chitosan nanofibers for bone and periodontal tissue engineering

Authors : Dr. Jayakumar Rangasamy, Dr. Sowmya Srinivasan, Shalumon, K.T.; Sowmya Srinivasan; Sathish, D.; Chennazhi, K.P.; Nair, S.V.

Publisher : Journal of Biomedical Nanotechnology

Fabrication of chitin-chitosan/nano ZrO2 composite scaffolds for tissue engineering applications

Authors : Dr. Jayakumar Rangasamy, Dr. Sowmya Srinivasan, Ramachandran, R.; Sudheesh Kumar, P.T.; Divyarani, V.V.; Chennazhi, K.P.; Tamura, H.; Nair, S.V.

Publisher : International Journal of Biological Macromolecules

β-Chitin hydrogel/nano hydroxyapatite composite scaffolds for tissue engineering applications

Authors : Dr. Sowmya Srinivasan, Dr. Jayakumar Rangasamy, Sudheesh Kumar, P.T.; Lakshmanan, V.-K.; Tamura, H.; Nair, S.V.

Publisher : Carbohydrate Polymers

Chitin Scaffolds in Tissue Engineering

Authors : Prof. Shantikumar Nair, Dr. Jayakumar Rangasamy, Dr. Sowmya Srinivasan, Chennazhi, K.P.; Furuike, T.; Tamura, H.

Publisher : International Journal of Molecular Sciences

Skin and muscle permeating antibacterial nanoparticles for treating Staphylococcus aureus infected wounds

Authors : Dr. Sabitha M., Dr. Raja Biswas, Dr. Jayakumar Rangasamy, V. Dhanalakshmi, Nimal, T. R.

Publisher : Journal of Biomedical Materials Research - Part B Applied Biomaterials

Biocompatible β-chitin Hydrogel/nanobioactive Glass Ceramic Nanocomposite Scaffolds for Periodontal Bone Regeneration

Authors : Dr. Sowmya Srinivasan, Dr. Jayakumar Rangasamy, Kumar, P.T.S.; Chennazhi, K.P.; Nair, S.V.; Tamura, H.

Publisher : Trends in Biomaterials and Artificial Organs

Bilayered Construct for Simultaneous Regeneration of Alveolar Bone and Periodontal Ligament

Authors : Dr. Sowmya Srinivasan, Dr. Jayakumar Rangasamy, Nivedhitha Sundaram M.; Deepthi, S.; Bumgardener, J.D.

Publisher : Journal of Biomedical Materials Research - Part B Applied Biomaterials

Fluconazole Loaded Chitin Nanogels as a Topical Ocular Drug Delivery Agent for Corneal Fungal Infections

Authors : Dr. Raja Biswas, Dr. Jayakumar Rangasamy, Dr. Sabitha M., N. Mohammed, N. Rejinold, S., Mangalathillam, S.

Publisher : Journal of Biomedical Nanotechnology

Development and Evaluation of 5-fluorouracil Loaded Chitin Nanogels for Treatment of Skin Cancer

Authors : Dr. Sabitha M., Dr. Jayakumar Rangasamy, N. Rejinold, S., Nair, A., Lakshmanan, V. - K., Nair, S. V

Publisher : Carbohydrate Polymers

Nanogels for Delivery, Imaging and Therapy

Authors : Dr. Sabitha M., Dr. Jayakumar Rangasamy, Dr. Rajitha Panonnummal, A. J. Sivaram, Maya, S.

Publisher : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

Curcumin Nanospheres by Surfactant Free Wet Milling Method (In Press)

Authors : Dr. Sabitha M., Dr. Jayakumar Rangasamy, Prof. Shantikumar Nair, T. R. Anuraj, N Rejinold, S., Biswas, R., Saroj, S., Shantikumar V Nair

Publisher : Journal of Biomedical Nanotechnology

Synthesis, Characterization and Biological Activities of Curcumin Nanospheres

Authors : Dr. Sabitha M., Dr. Jayakumar Rangasamy, Dr. Raja Biswas, T. R. Arunraj, Rejinold, N. S., Mangalathillam, S., Saroj, S

Publisher : Journal of Biomedical Nanotechnology

Acitretin and Aloe-Emodin Loaded Chitin Nanogel for the Treatment of Psoriasis

Authors : Dr. Rajitha Panonnummal, Swati Gupta, Dr. Jayakumar Rangasamy, G. Divya, Sabitha, M

Publisher : European Journal of Pharmaceutics and Biopharmaceutics

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