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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Journal of Biomaterials and Tissue Engineering
Source : Journal of Biomaterials and Tissue Engineering, Volume 5, Number 6", publication date ="2015-06-01T00:00:00, p.458-464 (2015)
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2015
Abstract : In the recent times, significant development has been achieved in the tissue engineering field using alginate and chitosan. Moreover, hydrogels of these successful macromolecules contribute enormously towards the development of novel biomedical materials. The present paper depicts the preparation and analysis of different kinds of hydrogels using the combination of alginate, chitosan, chitooligosacchrides and collagen (alginate-chitosan-cos-collagen), and also tested in vitro with human keratinocyte (HaCaT) cells for considering these composites as skin tissue substitute. Furthermore, the prepared hydrogels are chemically characterized, where the total porosity of the scaffold is found to be gt;90% with 33500 m of pore size. The newly developed scaffolds through freeze-drying method showed excellent biocompatibility, cell adhesion and proliferation with HaCaT cells. Addition of collagen, alginate with chitosan hydrogel further improved the biocompatible nature that mimics the functional environment of skin.
Cite this Research Publication : J. Venkatesan, Dr. Jayakumar Rangasamy, Anil, S., Chalisserry, E. P., Pallela, R., and Kim, S. - K., “Development of Alginate-Chitosan-Collagen Based Hydrogels for Tissue Engineering”, Journal of Biomaterials and Tissue Engineering, vol. 5, pp. 458-464, 2015.