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Development of Alginate-Chitosan-Collagen Based Hydrogels for Tissue Engineering

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Journal of Biomaterials and Tissue Engineering

Source : Journal of Biomaterials and Tissue Engineering, Volume 5, Number 6", publication date ="2015-06-01T00:00:00, p.458-464 (2015)

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Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2015

Abstract : In the recent times, significant development has been achieved in the tissue engineering field using alginate and chitosan. Moreover, hydrogels of these successful macromolecules contribute enormously towards the development of novel biomedical materials. The present paper depicts the preparation and analysis of different kinds of hydrogels using the combination of alginate, chitosan, chitooligosacchrides and collagen (alginate-chitosan-cos-collagen), and also tested in vitro with human keratinocyte (HaCaT) cells for considering these composites as skin tissue substitute. Furthermore, the prepared hydrogels are chemically characterized, where the total porosity of the scaffold is found to be gt;90% with 33500 m of pore size. The newly developed scaffolds through freeze-drying method showed excellent biocompatibility, cell adhesion and proliferation with HaCaT cells. Addition of collagen, alginate with chitosan hydrogel further improved the biocompatible nature that mimics the functional environment of skin.

Cite this Research Publication : J. Venkatesan, Dr. Jayakumar Rangasamy, Anil, S., Chalisserry, E. P., Pallela, R., and Kim, S. - K., “Development of Alginate-Chitosan-Collagen Based Hydrogels for Tissue Engineering”, Journal of Biomaterials and Tissue Engineering, vol. 5, pp. 458-464, 2015.

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