Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Carbohydrate Polymers
Source : Carbohydrate Polymers, Volume 89, Number 3, p.1003-1007 (2012)
Url : http://www.scopus.com/inward/record.url?eid=2-s2.0-84861651472&partnerID=40&md5=44c7139c4b9c02fbf0781f84a29f7964
Keywords : Cells, chitosan, Clinical application, Coagulation, Current limitation, cytotoxicity, Diseases, Drug delivery, gelation, In-vitro, Metformins, Nanoparticles, O-carboxymethyl chitosans, Pancreatic cancers, pH sensitive, Spherical morphologies, toxicity
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2012
Abstract : In this work we developed metformin loaded O-carboxymethyl chitosan (O-CMC) nanoparticles (NPs) by ionic-gelation method. The prepared NPs of 240 ± 50 nm size with spherical morphology exhibited a pH sensitive release of metformin in vitro. Cytotoxicity studies showed that the drug-incorporated NPs induced significant toxicity on pancreatic cancer cells (MiaPaCa-2) compared to normal cells (L929). Metformin loaded NPs exhibited nonspecific internalization by normal and pancreatic cancer cells; however metformin released from the NPs induced preferential toxicity on pancreatic cancer cells. Our preliminary studies suggested that such a novel approach could possibly overcome the current limitations of metformin in its clinical application against pancreatic cancer. © 2012 Elsevier Ltd. All rights reserved.
Cite this Research Publication : K. S. Snima, Dr. Jayakumar Rangasamy, Unnikrishnan, A. G., Nair, S. V., and Lakshmanan, V. K., “O-Carboxymethyl Chitosan Nanoparticles for Metformin Delivery to Pancreatic Cancer Cells”, Carbohydrate Polymers, vol. 89, pp. 1003-1007, 2012.