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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : International Journal of Biological Macromolecules
Source : International Journal of Biological Macromolecules, Volume 63, p.154-157 (2014)
Keywords : Amidase encapsulation; Immunogenicity; Staphylococcus aureus
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2014
Abstract : This work reports the development of amidase encapsulatednbsp;emO/em-carboxymethyl chitosan nanoparticles (Ami-emO/em-CMC NPs) of 300nbsp;±nbsp;50nbsp;nm size by ionic cross-linking method. The prepared Ami-emO/em-CMC NPs had an encapsulation efficiency of 55.39%. Haemolysis assay and cytotoxicity studies proved the hemocompatibility and cytocompatibility of the prepared NPs. The sustained release of Ami from the NPs is expected to prolong its immunogenicity and in turn lead to development of better protective immunity againstnbsp;emStaphylococcus aureus/emnbsp;infections.
Cite this Research Publication : K. T. Smitha, Sreelakshmi, M., Nisha, N., Dr. Jayakumar Rangasamy, and Dr. Raja Biswas, “Amidase encapsulated O-carboxymethyl chitosan nanoparticles for vaccine delivery”, International Journal of Biological Macromolecules, vol. 63, pp. 154-157, 2014.