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Publication Type : Journal Article
Thematic Areas : Medical Sciences
Publisher : Indian J Gastroenterol
Source : Indian J Gastroenterol, Volume 36, Issue 6, p.445-451 (2017)
Keywords : adolescent, adult, aged, Aged, 80 and over, Cohort Studies, Databases, Factual, female, Gastrointestinal Neoplasms, Humans, India, Internet, male, middle aged, Multicenter Studies as Topic, Neuroendocrine Tumors, Pancreatic Neoplasms, Registries, Sex Factors, Time Factors, Young Adult
Campus : Kochi
School : School of Medicine
Department : Gastrointestinal Surgery
Year : 2017
Abstract : INTRODUCTION: /bGastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare tumors. We report data of 407 GEP-NET cases from a neuroendocrine tumor (NET) registry in India./ppbMETHODS: /bThe AP-NET registry is an open-label, multicenter, longitudinal observational registry of patients with GEP-NETs in which six tertiary care oncology centers contributed data. Data was prospectively entered in a dedicated computerized database and was reviewed retrospectively. The patients were divided into three cohorts-those diagnosed from 2001 to 2005, from 2006 to 2010, and from 2011 to 2016./ppbRESULTS: /bOf the 407 cases registered, 37 were in Cohort I, 136 in Cohort II, and 234 in Cohort III. Majority were symptomatic with only 98 patients (24.0%) asymptomatic. The most common presentation of non-functional tumors was abdominal pain (42.4%), while functional tumors presented most commonly with carcinoid syndrome. Use of DOTA-PET, introduced in 2011, has increased evaluation in 33.3% patients in Cohort III. The most common primary site was pancreas in all three cohorts. Male preponderance (58.3%) was seen. Histopathological grading was obtained in 230 (56.5%) patients-118 (29%) Grade I, 74 (18.2%) Grade II, and 36 (8.8%) Grade III NET./ppbCONCLUSION: /bThis report highlights changing trends in the diagnosis and reporting of NETs over the last 15 years.
Cite this Research Publication : J. Palepu, Shrikhande, S. V., Bhaduri, D., Shah, R. C., Sirohi, B., Chhabra, V., Dhar, P., Sastry, R., and Sikora, S., “Trends in diagnosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in India: A report of multicenter data from a web-based registry.”, Indian J Gastroenterol, vol. 36, no. 6, pp. 445-451, 2017.