ProgramsView all programs
From the news
- Chancellor Amma Addresses the Parliament of World’s Religions
- Amrita Students Qualify for the European Mars Rover Challenge
Publication Type : Journal Article
Publisher : Drug Res (Stuttg)
Source : Drug Res (Stuttg), Volume 69, Issue 12, p.695-698 (2019)
Campus : Kochi
School : School of Pharmacy
Department : Pharmacology
Year : 2019
Abstract : OBJECTIVE:Many drugs in current practice require additional safety labels in order to prevent potential risks to the major organ system. Psychotropic agent clozapine has been reported to produce myocarditis and other cardiac complications on repeated use. Our study aimed to establish the role of clozapine in vascular damage associated with nitric oxide metabolism. METHOD:Isolated aortic strips incubated with clozapine at different dose levels were estimated for nitrite release and antioxidant systems such as glutathione and catalase. Vascular integrity assessment was performed by recording the acetylcholine induced relaxation of phenyephrine pre-contracted aorta. RESULT:From our study, it was found that clozapine depletes the nitric oxide level in the endothelium and enhance the oxidative stress. The aorta fails to relax completely after the addition of acetylcholine indicates the deranged eNOS signaling in the endothelium. CONCLUSION:From the experimental findings, it was concluded that clozapine could depress the eNOS regulation and thereby perhaps initiates cardiovascular complications through subsequent vascular events.
Cite this Research Publication : G. M. Nair, Skaria, D. Sheba, James, T., and S.K. Kanthlal, “Clozapine Disrupts Endothelial Nitric Oxide Signaling and Antioxidant System for its Cardiovascular Complications.”, Drug Res (Stuttg), vol. 69, no. 12, pp. 695-698, 2019.