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Publication Type : Journal Article
Thematic Areas : Medical Sciences
Publisher : Indian Journal of Experimental Biology
Source : Indian Journal of Experimental Biology, Volume 43, Number 5, p.445-449 (2005)
Keywords : 17-Hydroxysteroid Dehydrogenases, 3(or 17)beta hydroxysteroid dehydrogenase, 3-Hydroxysteroid Dehydrogenases, alcohol, animal, Animalia, Animals, antioxidant, Antioxidants, article, drug effect, enzymology, Ethanol, hydroxysteroid dehydrogenase, male, metabolism, rat, Rats, reactive oxygen metabolite, Reactive Oxygen Species, Testis, Wistar, Wistar rat
Campus : Kochi
School : School of Medicine
Department : Biochemistry
Year : 2005
Abstract : In order to find out the effect of chronic ethanol administration on testicular antioxidant system and steroidogenic enzyme activity, male rats fed with ethanol 1.6g/kg body weight per day for four weeks were studied. Besides a drastic reduction in body and testis weight, there was decrease in ascorbic acid, reduced glutathione and activities of superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase in the testicular tissue of the treated animals. Simultaneously, there was increase in lipid peroxidation and glutathione S-transferase activity. Activities of 3 β-hydroxy steroid dehydrogenase and 17 β-hydroxy steroid dehydrogenase were also found decreased in the treated animals. The results indicate that chronic ethanol administration resulted in increase in oxidative stress and decrease in the activities of steroidogenic enzymes in the rat testes.
Cite this Research Publication : D. M. Vasudevan, Maneesh, M., Jayalekshmi, H., Dutta, S., and Chakrabarti, A., “Effect of chronic ethanol administration on testicular antioxidant system and steroidogenic enzyme activity in rats”, Indian Journal of Experimental Biology, vol. 43, pp. 445-449, 2005.