Publication Type : Journal Article
Thematic Areas : Center for Computational Engineering and Networking (CEN)
Publisher : International Journal of Drug Delivery, Advanced Research Journals
Source : International Journal of Drug Delivery, Advanced Research Journals, Volume 7, Issue 1, Number 1, p.27-31 (2015)
Campus : Amritapuri, Coimbatore
School : School of Biotechnology, School of Engineering
Center : Computational Chemistry, Computational Engineering and Networking
Department : Electronics and Communication
Year : 2015
Abstract : Computational modeling of polymeric nanoparticles as drug carriers have been extensively studied due to their varied functionalities, tunable structures and the capability of controlled drug release. Nano particulate polymeric drug delivery systems enable a cell specific targeting with negligible side effects and drug release based on change in physiological conditions. Eight common polymers are modeled and the various properties have been predicted. ADMET, QSAR, thermodynamic and electronic properties have been predicted and compared using SAR as well as quantum mechanical density functional methods. Comparison of the predicted properties suggests that chitosan, which is a natural polymer and has some advantages over others is a promising drug carrier candidate for tumor. © 2014, Advanced Research Journals. All rights reserved.
Cite this Research Publication : Ann Elizabeth Silviya, Kavitha G., Narayanankutty Karuppath, and P. K. Krishnan Namboori, “Insilico modeling of chitosan as a drug delivery system”, International Journal of Drug Delivery, vol. 7, no. 1, pp. 27-31, 2015