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Liver in leprosy: I. Functional changes

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Leprosy In India

Source : Leprosy In India, Volume 52, Number 3, p.416-422 (1980)

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Keywords : alkaline phosphatase, aminotransferase, Blood Proteins, cholesterol, cholesterol blood level, human, lepromatous leprosy, leprosy, liver, liver function, Liver Function Tests, Transaminases, tuberculoid leprosy

Campus : Kochi

School : School of Medicine

Department : Biochemistry

Year : 1980

Abstract : Liver function tests were carried out in 79 leprosy patients, out of which 28 patients were being treated and 42 patients were not receiving any treatment. The rest (9 patients) were clinically quiescent. In the untreated group there were 28 tuberculoid and 14 lepromatous cases. The 28 patients receiving treatment were composed of equal number of lepromatous and tuberculoid groups. The liver function tests of 10 of the untreated tuberculoid patients were repeated after six months of specific therapy with D.D.S. The values of liver function tests of these patients were compared with that of 20 normal adults. The most important abnormality observed in the patients was a reversal of albumin/globulins ratio which was more common in the lepromatous group than in the tuberculoid group. Treatment with D.D.S. has resulted in the reduction of the serum globulin. There were no changes in transaminases and alkaline phosphatase activities in the untreated patients. However, a rise in the above enzymes was observed in patients on treatment. The mean serum cholesterol values of the patients were lower than that of the controls.

Cite this Research Publication : K. Robins, Vijayakumar, T., Gopinath, T., and Vasudevan, D. M., “Liver in leprosy: I. Functional changes”, Leprosy In India, vol. 52, pp. 416-422, 1980.

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