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Protein Nanomedicine Exerts Cytotoxicity toward CD34+ CD38– CD123+ Leukemic Stem Cells

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : ACS Biomaterials Science & Engineering,

Source : ACS Biomaterials Science & Engineering, Volume 1, Number 12, p.1194-1199 (2015)

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Campus : Coimbatore, Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2015

Abstract : The efficacy of protein-vorinostat nanomedicine (NV) is demonstrated in leukemic stem cells (LSC) isolated from refractory acute myeloid leukemia (AML) patient samples, where it successfully ablated both CD34+ CD38– CD123+ LSC and non-LSC “leukemic blast” compartments, without inducing myelosuppression or hemotoxicity. Besides, NV also exerted excellent synergistic lethality against leukemic bone marrow cells (BMC) at lower concentrations (0.1 μM) in combination with DNA methyltransferase (DNMT) inhibitor, decitabine. Considering the extermination of resilient LSC and synergism with decitabine, NV shows promise for clinical translation in the setting of a more tolerable and effective epigenetic targeted therapy for leukemia

Cite this Research Publication : P. Chandran, Pavithran, K., Sidharthan, N., Sasidharan, A., Shantikumar V Nair, and Dr. Manzoor K., “Protein Nanomedicine Exerts Cytotoxicity toward CD34+ CD38– CD123+ Leukemic Stem Cells”, ACS Biomaterials Science & Engineering, vol. 1, pp. 1194-1199, 2015.

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