Publication

Abstract : Introduction: This case series explores the effect of Dashmoola Ghrita Marsha Nasya on migraine in relation to CGRP, a key neuromodulator in migraine pathophysiology. While CGRP has been extensively studied in modern medicine, its modulation through traditional Ayurvedic therapies remains underexplored. Clinical Findings: Three patients with episodic migraine presented with moderate to severe headaches, photophobia, and nausea. All had elevated MIDAS scores and serum CGRP levels, indicating significant disability and active neuroinflammatory response. Intervention: Patients underwent Marsha Nasya with Dashmoola Ghrita (8 bindu) for seven consecutive days. Outcomes: Post-treatment, patients demonstrated an average 34% reduction in MIDAS scores and an average 40% decrease in serum CGRP levels, indicating both symptomatic relief and biochemical parameters. Conclusion: Dashmoola Ghrita Marsha Nasya may exert a neuro-modulatory effect on CGRP and improve clinical outcomes in migraine. These findings suggest the potential role of integrating Nasya therapy with biomarker-based evaluation in the management of migraine.