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Course Detail

Course Name Bio Informatics
Course Code 18CA332
Program M. C. A., M. C. A. ( Offered at Mysuru Campus )
Credits Three
Year Taught 2018
Degree Postgraduate (PG)
School School of Arts and Sciences, School of Engineering
Campus Kochi, Mysuru, Amritapuri


Introduction to Bioinformatics: Definition – Importance and Uses of Bioinformatics-Information Technology – Systems Biology.

Introduction to Nucleic Acids: DNA and RNA as Genetic Materials – Structure of Nucleic Acids – Nucleosides and Nucleotides – DNA Double Helix. Central Dogma of Molecular Biology – Nature of Genetic Code – Deciphering Genetic Code – Wobble Hypothesis – Universalities and Exceptions. Applications of Data Mining to Bioinformatics Problems – Biological Data – Databases -Protein Sequencing – Nucleic Acid Sequencing – Sequence to Structure Relationship.

Bioinformatics Software: Clustal V – Clustal W 1.7 – RasMol – Oligo – Molscript – Treeview – Alscript – Genetic Analysis Software- Phylip.

Biocomputing: Introduction to String Matching Algorithms – Database Search Techniques -Sequence Comparison and Alignment Techniques – Use of Biochemical Scoring Matrices –Introduction to Graph Matching Algorithms – Automated Genome Comparison and its Implication – Automated Gene Prediction – Automated Identification of Bacterial Operons and Pathways – Introduction to Signaling Pathways and Pathway Regulation. Gene Arrays – Analysis of Gene Arrays – Machine Learning Methods in Bioinformatics – Hidden Markov models – Applications of HMM in gene identification and Profiles HMMs – Neural Networks and Support Vector machines.

Text Books

  1. Claverie J.M and Notredame C, “Bioinformatics for Dummies”, Second Edition,Wiley, 2003.
  2. Pierre Baldi and Soren Brunak, “Bioinformatics – The Machine Learning Approach”, Second Edition,A Bradford Book, 2001.
  3. RastogiS.C, Mendiratt N. and Rastogi P “Bioinformatics: Concepts, Skills & Applications”, CBS Publishers & Distributors, 2004.
  4. Fogel G.B. and Corne D.W, “Evolutionary Computation in Bioinformatics”, Morgan Kaufmann, 2003.

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