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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : IET Nanobiotechnology, Institution of Engineering and Technology,
Source : IET Nanobiotechnology, Institution of Engineering and Technology, Volume 11, Number 7, p.782-789 (2017)
Keywords : Anti-cancer agents, Biochemistry, biocompatibility, Cells, Cellular uptake, Cytology, Diseases, Haemocompatibility, Medical nanotechnology, Nanoprecipitation method, Prostate cancer cells, Prostate cancers, Surface zeta potential, Therapeutic agents, Urology
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences
Year : 2017
Abstract : Phytomedicine research received tremendous attention for novel therapeutic agent due to their safety and low cost. We assessed a novel nanoformulation of Biophytum sensitivum (BS), natural flavonoids for their improved efficacy and superior bioavailability against crude extract for prostate cancer cells (PC3). We prepared a nanomedicine of BS by nanoprecipitation method and size analysis via DLS and SEM revealed a range of 100-118 nm and surface zeta potential as -9.77 mV. FTIR was performed to evaluate functional for presence of carbonyl and aromatic rings, respectively. Human PC3 cells showed concentration at 0.5, 0.8, and 1 mg/ml dependent cytotoxicity 22, 39, and 56% for 24 h, whereas 43, 41, and 67% for 48 h of BS nanomedicine compared with crude 11, 22, and 53% for 24 h and 38, 31, and 60% for 48 h, respectively. Haemocompatibility of BS nanomedicine at the concentration of 0.5, 0.8, and 1 mg/ml did not show blood aggregation. Cellular uptake was confirmed using rhodamine-conjugated BS nanomedicine for 48 h. Interestingly, BS nanomedicine 1 mg/ml decreases the nitrite productions in PC3 cells. Collectively, BS nanomedicine has the potential anti-cancer agents with biocompatible and enhanced efficacy can be beneficial for the treatment of prostate cancer. © The Institution of Engineering and Technology 2017.
Cite this Research Publication : A. Raju, Shantikumar V Nair, and Lakshmanan, V. - K., “Biophytum Sensitivum Nanomedicine Reduces Cell Viability and Nitrite Production in Prostate Cancer Cells”, IET Nanobiotechnology, vol. 11, pp. 782-789, 2017.