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Publication Type : Journal Article
Publisher : Research Journal of Pharmacy and Technology
Source : Research Journal of Pharmacy and Technology, Volume 12, Issue 8, p.3735-3738 (2019)
Keywords : ALDEN Algorithm, fluconazole, Naranjo ADR probability scale, Stevens Johnson syndrome, toxic epidermal necrolysis
Campus : Kochi
School : School of Medicine, School of Pharmacy
Department : Pharmacy Practice
Year : 2019
Abstract : Stevens-Johnson syndrome (SJS) is a rare cutaneous reaction characterised by mucosal erosions and epidermal detachment of about less than 10% of the total area of body skin. The incidence of SJS is approximately 1-6 cases per million person-years. The incidence of fluconazole induced SJS is less than 1%. Here the patient came with complaints of scaly lesions over chest and axilla following which he was started on topical antifungals (Lulliconazole) and antihistamines with the suspicion of Tinea versicolor. Though few lesions resolved on treatment, the patient later developed a small scaly macule over the left upper arm. Thus the patient upon further evaluation was given a stat dose of Tablet Fluconazole 400mg. Following this, the patient developed swelling of lower lips and tip of the glans and erythema over palms. This was later confirmed as Stevens-Johnson syndrome. The reaction was suspected to have occurred in association with Fluconazole. Fluconazole had a probable causal relationship with Stevens Johnson Syndrome as per ALDEN Algorithm in the EuroSCAR study. As per the Naranjo ADR probability scale, the causality assessment score for this reaction was found to be 5 which indicates a probable causal relationship. Clinicians must be more vigilant while prescribing Fluconazole by conducting regular monitoring of such patients and carrying out early diagnosis of such reactions.
Cite this Research Publication : R. Antony, Fernandez, A., Lekshmi, S., Velayudhan, S., Jose, S., and Meenu Vijayan, “Case Report on Fluconazole Induced Stevens - Johnson Syndrome”, Research Journal of Pharmacy and Technology, vol. 12, no. 8, pp. 3735-3738, 2019.