Publication Type : Journal Article
Publisher : Journal of Food Biochemistry, Wiley Online Library,
Source : Journal of Food Biochemistry, Wiley Online Library, Volume 44, Issue 11, p.e13369 (2020)
Url : https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.13369
Campus : Kochi
School : School of Pharmacy
Department : Pharmacology
Year : 2020
Abstract : Inflammatory bowel disease (IBD) is one of the major complications of the gastrointestinal tract, characterized by chronic inflammation, which disturbs the quality of life of the affected individuals. Genetic predisposition, immune, inflammatory, and enzyme‐mediated signaling cascades are the primary mechanisms involved in the pathogenesis of the disease. Currently, the treatment strategy involves the maintenance of remission and induction of inflammation by anti‐inflammatory agents and immune suppressants. Polyphenol‐containing diets, including fruits and vegetables of regular use, possess anti‐inflammatory, and antioxidant potential through the inhibition of major contributing pathways to IBD. This review discusses the role of these dietary polyphenols in downregulating the major signaling cascades in IBD. Our review encourages the development of nutritional strategies to improve the efficiency of current therapies for IBD and reduce the risks of side effects associated with conventional therapy.
Cite this Research Publication : V. S. Arya, Kanthlal, S. K., and Linda, G., “The role of dietary polyphenols in inflammatory bowel disease: A possible clue on the molecular mechanisms involved in the prevention of immune and inflammatory reactions”, Journal of Food Biochemistry, vol. 44, no. 11, p. e13369, 2020.