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Publication Type : Journal Article
Publisher : International Journal of Polymeric Materials and Polymeric Biomaterials
Source : International Journal of Polymeric Materials and Polymeric Biomaterials., 2017, 6(13): 645-657.
Keywords : 3T3 FIBROBLASTS, Bacteria, Caprolactone, Cell attachments, Cell culture, collagen, Controlled drug delivery, Electrospinning, Gram positive, Gram-negative bacteria, Poly(L-lactide-co-caprolactone), Specific interface, Wound dressings
Campus : Amritapuri
School : School of Biotechnology
Department : biotechnology
Year : 2017
Abstract : Here we report a novel bioactive electrospun mat based on poly(L-lactide-co-caprolactone) (PLLC) and collagen for wound dressing and sustained drug delivery of gentamicin. PLLC/collagen electrospun mat loaded with 10% gentamicin showed bioactivity for 15 days against Gram-positive and Gram-negative bacteria. The in vitro cell culture of 3T3 fibroblasts confirmed that these electrospun mat provide an increased specific interface area and hydrophilicity to enhance cell attachment, proliferation, and migration. The modified PLLC/collagen mat provided an excellent enhancement in properties of antibacterial wound dressings with a minimum in vitro toxicity and high potency for promoting wound healing stages. © 2017 Taylor amp; Francis.
Cite this Research Publication : C. R. Reshmi, Menon, T., Anupama Binoy, Dr. Nandita Mishra, Elyas, K. K., and Sujith, A., “Poly(L-lactide-co-caprolactone)/collagen electrospun mat: Potential for wound dressing and controlled drug delivery”, International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 66, no. 13, pp. 645-657, 2017.